ID CYSZ_PASMU Reviewed; 267 AA.
AC Q9CKC9;
DT 02-NOV-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 27-MAR-2024, entry version 114.
DE RecName: Full=Sulfate transporter CysZ {ECO:0000255|HAMAP-Rule:MF_00468};
GN Name=cysZ {ECO:0000255|HAMAP-Rule:MF_00468}; OrderedLocusNames=PM1694;
OS Pasteurella multocida (strain Pm70).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Pasteurella.
OX NCBI_TaxID=272843;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Pm70;
RX PubMed=11248100; DOI=10.1073/pnas.051634598;
RA May B.J., Zhang Q., Li L.L., Paustian M.L., Whittam T.S., Kapur V.;
RT "Complete genomic sequence of Pasteurella multocida Pm70.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:3460-3465(2001).
CC -!- FUNCTION: High affinity, high specificity proton-dependent sulfate
CC transporter, which mediates sulfate uptake. Provides the sulfur source
CC for the cysteine synthesis pathway. {ECO:0000255|HAMAP-Rule:MF_00468}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_00468}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_00468}.
CC -!- SIMILARITY: Belongs to the CysZ family. {ECO:0000255|HAMAP-
CC Rule:MF_00468}.
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DR EMBL; AE004439; AAK03778.1; -; Genomic_DNA.
DR RefSeq; WP_010907292.1; NC_002663.1.
DR AlphaFoldDB; Q9CKC9; -.
DR SMR; Q9CKC9; -.
DR STRING; 272843.PM1694; -.
DR EnsemblBacteria; AAK03778; AAK03778; PM1694.
DR KEGG; pmu:PM1694; -.
DR PATRIC; fig|272843.6.peg.1715; -.
DR HOGENOM; CLU_070331_1_0_6; -.
DR OrthoDB; 5292355at2; -.
DR Proteomes; UP000000809; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015116; F:sulfate transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0019344; P:cysteine biosynthetic process; IEA:UniProtKB-UniRule.
DR GO; GO:0000103; P:sulfate assimilation; IEA:InterPro.
DR HAMAP; MF_00468; CysZ; 1.
DR InterPro; IPR022985; Sulfate_CysZ.
DR PANTHER; PTHR37468; SULFATE TRANSPORTER CYSZ; 1.
DR PANTHER; PTHR37468:SF1; SULFATE TRANSPORTER CYSZ; 1.
DR Pfam; PF07264; EI24; 1.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis; Cell inner membrane; Cell membrane;
KW Cysteine biosynthesis; Membrane; Reference proteome; Sulfate transport;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..267
FT /note="Sulfate transporter CysZ"
FT /id="PRO_0000204343"
FT TRANSMEM 29..49
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00468"
FT TRANSMEM 73..93
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00468"
FT TRANSMEM 149..169
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00468"
FT TRANSMEM 212..232
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00468"
SQ SEQUENCE 267 AA; 30425 MW; 399099CABD68033A CRC64;
MLSHAELKQG FHYFMMGWHL ITQKGLRRFV IMPILLNIVL LSGLFWLFIT QIEKMIGMLM
LSIPDWLSWL SSILLIFAIL MILVLFYFVF TTLSGFIAAP FNGLLAEKVE KMLTGENLVE
GSVWDFMKDI PRMLGREWQK LVYSLPKLII LFLLGFVPVL GQSVIPIIVT LFTAWMMAIQ
YCDYPFDNHK VPFFVMKAEL AEKRALSLSF GGLVMLCTFI PLVNLVVIPV AVCGATAMWV
THFRDHLAMK PLNQEGVSRV STVSIVK
//
