ID D0EXE4_DANRE Unreviewed; 376 AA.
AC D0EXE4; A0A8M1NSL6;
DT 24-NOV-2009, integrated into UniProtKB/TrEMBL.
DT 24-NOV-2009, sequence version 1.
DT 27-MAR-2024, entry version 100.
DE RecName: Full=Thromboxane A2 receptor {ECO:0000256|ARBA:ARBA00017628};
DE AltName: Full=Prostanoid TP receptor {ECO:0000256|ARBA:ARBA00029815};
GN Name=ptger1c {ECO:0000313|Ensembl:ENSDARP00000102874,
GN ECO:0000313|RefSeq:NP_001159763.1,
GN ECO:0000313|ZFIN:ZDB-GENE-120917-4};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|EMBL:ACX47465.1};
RN [1] {ECO:0000313|EMBL:ACX47465.1}
RP NUCLEOTIDE SEQUENCE.
RA Kwok A.H.Y., Wang Y., Ho J.C.W., Leung F.C.;
RT "Molecular characterization of zebrafish prostaglandin receptors.";
RL Submitted (SEP-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSDARP00000102874}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000102874};
RG Ensembl;
RL Submitted (JUN-2011) to UniProtKB.
RN [3] {ECO:0000313|RefSeq:NP_001159763.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=22617193;
RA Kwok A.H., Wang Y., Leung F.C.;
RT "Molecular characterization of prostaglandin F receptor (FP) and E receptor
RT subtype 1 (EP(1)) in zebrafish.";
RL Gen. Comp. Endocrinol. 178:216-226(2012).
RN [4] {ECO:0000313|RefSeq:NP_001159763.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23892039; DOI=10.1016/j.bbrc.2013.07.075;
RA Iwasaki R., Tsuge K., Morimoto K., Inazumi T., Kawahara O., Kawahara A.,
RA Tsuchiya S., Sugimoto Y.;
RT "Molecular and pharmacological characterization of zebrafish 'contractile'
RT and 'inhibitory' prostanoid receptors.";
RL Biochem. Biophys. Res. Commun. 438:353-358(2013).
RN [5] {ECO:0000313|Ensembl:ENSDARP00000102874, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000102874};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [6] {ECO:0000313|RefSeq:NP_001159763.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=27333837;
RA Tang H., Liu Y., Li J., Yin Y., Li G., Chen Y., Li S., Zhang Y., Lin H.,
RA Liu X., Cheng C.H.;
RT "Gene knockout of nuclear progesterone receptor provides insights into the
RT regulation of ovulation by LH signaling in zebrafish.";
RL Sci. Rep. 6:28545-28545(2016).
RN [7] {ECO:0000313|RefSeq:NP_001159763.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; BX511096; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; GQ911589; ACX47465.1; -; mRNA.
DR RefSeq; NP_001159763.1; NM_001166291.1.
DR STRING; 7955.ENSDARP00000102874; -.
DR PaxDb; 7955-ENSDARP00000102874; -.
DR Ensembl; ENSDART00000111510.3; ENSDARP00000102874.2; ENSDARG00000078602.3.
DR GeneID; 100003535; -.
DR KEGG; dre:100003535; -.
DR AGR; ZFIN:ZDB-GENE-120917-4; -.
DR CTD; 100003535; -.
DR ZFIN; ZDB-GENE-120917-4; ptger1c.
DR eggNOG; KOG3656; Eukaryota.
DR HOGENOM; CLU_045991_3_0_1; -.
DR OMA; DIEMMAQ; -.
DR OrthoDB; 5355693at2759; -.
DR TreeFam; TF324982; -.
DR Proteomes; UP000000437; Alternate scaffold 3.
DR Proteomes; UP000000437; Chromosome 3.
DR Bgee; ENSDARG00000078602; Expressed in granulocyte.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004957; F:prostaglandin E receptor activity; IBA:GO_Central.
DR GO; GO:0004958; F:prostaglandin F receptor activity; IDA:ZFIN.
DR GO; GO:0004960; F:thromboxane receptor activity; IEA:InterPro.
DR GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
DR GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IBA:GO_Central.
DR CDD; cd15144; 7tmA_PGE2_EP1; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR008365; Prostanoid_rcpt.
DR InterPro; IPR001105; Thbox_rcpt.
DR PANTHER; PTHR11866; G-PROTEIN COUPLED RECEPTOR FAMILY 1 MEMBER; 1.
DR PANTHER; PTHR11866:SF33; THROMBOXANE A2 RECEPTOR; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR01788; PROSTANOIDR.
DR PRINTS; PR00429; THROMBOXANER.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000313|EMBL:ACX47465.1, ECO:0000313|RefSeq:NP_001159763.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 46..66
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 78..107
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 127..148
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 169..191
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 211..235
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 281..300
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 57..339
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
SQ SEQUENCE 376 AA; 41506 MW; 18693CE66103AE4E CRC64;
MDIFFTPSFP VLCQDSRGHN YTIPCADNQT LNSTSPSTVN PPAFGMSYFT MTLGALSNLT
ALAILAHSYA SFRRRAKVPF LLLASTLLLS DLAGHLITGA LALNLHLERV KHHGQMEVEP
PRIYCKLFGA CMVFFGLCPL LLGSAMAVER CIGITQPLLH STVVTMTRVR FSVLLITSMA
LTLAGLPLLN VGNYKPQFPG TWCFLPVNGP LSIADVSLTL AFSILGLLTL IVSLVSNTLS
GLKLLQARIK DGCLKSSAAR RHGSFSSSSL HSLDVEMMTQ LAVITVVSCV CWSPFLIYIL
MSVSRFYEGV SRPKHQCEKL FLLALRLASW NQILDPWVYI LLRRAVLRRV LQLLQPDRAV
YTQSSSYRDS HRKTIS
//
