ID D0I4E7_GRIHO Unreviewed; 1025 AA.
AC D0I4E7;
DT 15-DEC-2009, integrated into UniProtKB/TrEMBL.
DT 15-DEC-2009, sequence version 1.
DT 24-JAN-2024, entry version 36.
DE SubName: Full=RND multidrug efflux transporter {ECO:0000313|EMBL:EEY73925.1};
GN ORFNames=VHA_000612 {ECO:0000313|EMBL:EEY73925.1};
OS Grimontia hollisae CIP 101886.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC Grimontia.
OX NCBI_TaxID=675812 {ECO:0000313|EMBL:EEY73925.1, ECO:0000313|Proteomes:UP000003604};
RN [1] {ECO:0000313|EMBL:EEY73925.1, ECO:0000313|Proteomes:UP000003604}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CIP 101886 {ECO:0000313|EMBL:EEY73925.1,
RC ECO:0000313|Proteomes:UP000003604};
RG Los Alamos National Laboratory (LANL);
RG National Microbial Pathogen Data Resource (NMPDR);
RA Saunders E.H., Munk A.C., Tapia R., Green L., Rogers Y., Detter J.C.,
RA Bruce D., Brettin T.S., Colwell R.R., Huq A., Grim C.J., Hasan N.A.,
RA Bartels D., Vonstein V.;
RL Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EEY73925.1}.
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DR EMBL; ADAQ01000008; EEY73925.1; -; Genomic_DNA.
DR RefSeq; WP_005501788.1; NZ_ADAQ01000008.1.
DR AlphaFoldDB; D0I4E7; -.
DR GeneID; 58896142; -.
DR eggNOG; COG0841; Bacteria.
DR OrthoDB; 9757904at2; -.
DR Proteomes; UP000003604; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 3.30.70.1430; Multidrug efflux transporter AcrB pore domain; 2.
DR Gene3D; 3.30.70.1440; Multidrug efflux transporter AcrB pore domain; 1.
DR Gene3D; 3.30.70.1320; Multidrug efflux transporter AcrB pore domain like; 1.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR027463; AcrB_DN_DC_subdom.
DR InterPro; IPR001036; Acrflvin-R.
DR PANTHER; PTHR32063; -; 1.
DR PANTHER; PTHR32063:SF28; BLR2861 PROTEIN; 1.
DR Pfam; PF00873; ACR_tran; 1.
DR PRINTS; PR00702; ACRIFLAVINRP.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000003604};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..30
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 333..352
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 359..379
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 385..409
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 430..450
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 462..480
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 522..542
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 846..866
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 873..893
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 944..965
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 977..1003
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 1025 AA; 110185 MW; ED04C557314A20CB CRC64;
MKFTDIFIKR PVLAVSISFL IALLGLQSMF KMQVREYPDM TNTVVTISTS YYGASADLIQ
GFITTPLEQA VAQADNIDFM TSESVLGKST ITAYMKLNTD PNAALADILA KVNSVRAQLP
GEAEDPSVSM STGSTTAVMY IGFTSETLDS SQITDYLERV TKPQLFTVNG VASIDLYGGL
KYALRVWLDP AKMAAFNLTA TDVMGVLNAN NYQSATGQSI GTYMIYNGAA DTQVSDTNEL
KRLVVATQEG QVIRLGDIAK VTLEKSHDIY RATANGSEAV VAAINAAPTA NPINIAADVL
KKLPELERNM PSTIKMNVLY DSTVAINESI KEVVKTIIEA ALIVLVVITL FLGSFRAVLI
PIITIPLSLI GVAMMMELFG FSLNLMTLLA MVLAIGLVVD DAIVVLENVD RHIKLGESPF
RAAIIGTREI AVPVISMTLT LAAVYAPIAL MGGITGSLFK EFALTLAGAV FVSGIIALTL
SPMMCSKMLK ANEQPGKFEA KVHHFLDGMT ERYAKMLKSV MGMRPVIITF AVIVFASLPM
LFKLIPSELA PAEDKGVLVM MGTAPSTANL DYIQNTMAEV NQKLADQPEV AFSQVFSGVP
KSNQAFGIAS LVPWSERAAS QAEVVQRMAV EVKDIPGMAV TAFQMPELPG ASSGLPIQFV
ITTPNNFESL FQVASDILAE VKSNPQFVYS DMDLNFDSAT MKINIDKDKA GAYGVTMQDI
GITLGTMMAD GYVNRIDLDG RSYEVIPQVE RKYRLNPESV KGYYVRSASG EAVPLGSLIT
IDVVAEPRAL PHFNQLNSAT ISVAAAGMPM GDVIDWFENV AREKLPAGYQ HDYLGESRQF
VTEGSALVGT FMLALAVIFL VLAIQFESLR DPLVILVSVP LAICGALIAL ASGAATMNIY
SQVGLITLIG LITKHGILIC EVAKEEQLHR GVGKMEAVIE AAKVRLRPIL MTTAAMIAGL
IPLMYATGAG AAQRFSIGIV IVAGLAIGTL FTLFVLPVIY TYLASKHQPL PEFEEDLDAS
KKPAH
//
