ID D0J8H0_BLASP Unreviewed; 419 AA.
AC D0J8H0;
DT 15-DEC-2009, integrated into UniProtKB/TrEMBL.
DT 15-DEC-2009, sequence version 1.
DT 27-MAR-2024, entry version 82.
DE RecName: Full=Transcription termination/antitermination protein NusA {ECO:0000256|HAMAP-Rule:MF_00945};
GN Name=nusA {ECO:0000256|HAMAP-Rule:MF_00945,
GN ECO:0000313|EMBL:ACX83641.1};
GN OrderedLocusNames=BPLAN_001 {ECO:0000313|EMBL:ACX83641.1};
OS Blattabacterium sp. subsp. Periplaneta americana (strain BPLAN)
OS (Periplaneta americana symbiotic bacterium).
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Blattabacteriaceae; Blattabacterium.
OX NCBI_TaxID=600809 {ECO:0000313|EMBL:ACX83641.1, ECO:0000313|Proteomes:UP000002225};
RN [1] {ECO:0000313|EMBL:ACX83641.1, ECO:0000313|Proteomes:UP000002225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BPLAN {ECO:0000313|EMBL:ACX83641.1,
RC ECO:0000313|Proteomes:UP000002225};
RX PubMed=19880743; DOI=10.1073/pnas.0907504106;
RA Sabree Z.L., Kambhampati S., Moran N.A.;
RT "Nitrogen recycling and nutritional provisioning by Blattabacterium, the
RT cockroach endosymbiont.";
RL Proc. Natl. Acad. Sci. U.S.A. 106:19521-19526(2009).
CC -!- FUNCTION: Participates in both transcription termination and
CC antitermination. {ECO:0000256|HAMAP-Rule:MF_00945}.
CC -!- SUBUNIT: Monomer. Binds directly to the core enzyme of the DNA-
CC dependent RNA polymerase and to nascent RNA. {ECO:0000256|HAMAP-
CC Rule:MF_00945}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00945}.
CC -!- SIMILARITY: Belongs to the NusA family. {ECO:0000256|HAMAP-
CC Rule:MF_00945}.
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DR EMBL; CP001429; ACX83641.1; -; Genomic_DNA.
DR RefSeq; WP_012821170.1; NC_013418.2.
DR AlphaFoldDB; D0J8H0; -.
DR STRING; 600809.BPLAN_001; -.
DR KEGG; bpi:BPLAN_001; -.
DR eggNOG; COG0195; Bacteria.
DR HOGENOM; CLU_029242_2_2_10; -.
DR OrthoDB; 9807233at2; -.
DR Proteomes; UP000002225; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0006353; P:DNA-templated transcription termination; IEA:UniProtKB-UniRule.
DR GO; GO:0031564; P:transcription antitermination; IEA:UniProtKB-UniRule.
DR CDD; cd02134; KH-II_NusA_rpt1; 1.
DR CDD; cd22529; KH-II_NusA_rpt2; 1.
DR Gene3D; 3.30.300.20; -; 2.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR Gene3D; 3.30.1480.10; NusA, N-terminal domain; 1.
DR HAMAP; MF_00945_B; NusA_B; 1.
DR InterPro; IPR015946; KH_dom-like_a/b.
DR InterPro; IPR025249; KH_dom_NusA-like.
DR InterPro; IPR009019; KH_sf_prok-type.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR030842; NusA_bac.
DR InterPro; IPR036555; NusA_N_sf.
DR InterPro; IPR013735; TF_NusA_N.
DR InterPro; IPR010213; Tscrpt_termination_fac_NusA.
DR NCBIfam; TIGR01953; NusA; 1.
DR PANTHER; PTHR22648; TRANSCRIPTION TERMINATION FACTOR NUSA; 1.
DR PANTHER; PTHR22648:SF0; TRANSCRIPTION TERMINATION_ANTITERMINATION PROTEIN NUSA; 1.
DR Pfam; PF13184; KH_5; 1.
DR Pfam; PF08529; NusA_N; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR SUPFAM; SSF54814; Prokaryotic type KH domain (KH-domain type II); 2.
DR SUPFAM; SSF69705; Transcription factor NusA, N-terminal domain; 1.
DR PROSITE; PS50084; KH_TYPE_1; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_00945};
KW Elongation factor {ECO:0000313|EMBL:ACX83641.1};
KW Protein biosynthesis {ECO:0000313|EMBL:ACX83641.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000002225};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|HAMAP-
KW Rule:MF_00945};
KW Transcription {ECO:0000256|ARBA:ARBA00023163, ECO:0000256|HAMAP-
KW Rule:MF_00945};
KW Transcription antitermination {ECO:0000256|HAMAP-Rule:MF_00945};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015, ECO:0000256|HAMAP-
KW Rule:MF_00945};
KW Transcription termination {ECO:0000256|ARBA:ARBA00022472,
KW ECO:0000256|HAMAP-Rule:MF_00945}.
FT DOMAIN 6..124
FT /note="Transcription factor NusA N-terminal"
FT /evidence="ECO:0000259|Pfam:PF08529"
FT DOMAIN 233..300
FT /note="KH"
FT /evidence="ECO:0000259|Pfam:PF13184"
SQ SEQUENCE 419 AA; 48674 MW; 057622F531BD2A28 CRC64;
MDNEALIDSF SVFKDEKNID RASLMAILEE SIRCVLRKKY DSSKNYDIIV NPDQGDLEIW
RNRIVVQDGT VKDVNKEIEL STARKIEIDF EIGEEVTEKV ELKSLGRRAI LSLRQNLLSK
INEYDNTNIY KKFKNKIGEI INVEVYHILP KQIIMRDEEQ NEMVLPKQEQ IPNDFFRKGD
PVRALVKRVD WKDNKPLAIL TRKDDSFLEE LFKLEIPEVS EGLITVKKVA RIPGEKAKVS
VDSYDDRIDP IGACVGMKGS RIHPIVRELK NENIDVINYT TNIQLYITRA LSPAKVSMME
VNEEHKYVNV YVKLEEISKA IGRGGQNIRL ASQLTGYKIH IFRDFPYEDD VELTEFSDEI
EPEVLERFHK VGLTTAKSVL NYRNNDLSKR TNLEEKIINK VVSILKKEFE EEIYNNYNN
//
