ID D0KW07_HALNC Unreviewed; 804 AA.
AC D0KW07;
DT 15-DEC-2009, integrated into UniProtKB/TrEMBL.
DT 15-DEC-2009, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE SubName: Full=MMPL domain protein {ECO:0000313|EMBL:ACX94934.1};
GN OrderedLocusNames=Hneap_0068 {ECO:0000313|EMBL:ACX94934.1};
OS Halothiobacillus neapolitanus (strain ATCC 23641 / c2) (Thiobacillus
OS neapolitanus).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Chromatiales;
OC Halothiobacillaceae; Halothiobacillus.
OX NCBI_TaxID=555778 {ECO:0000313|EMBL:ACX94934.1, ECO:0000313|Proteomes:UP000009102};
RN [1] {ECO:0000313|EMBL:ACX94934.1, ECO:0000313|Proteomes:UP000009102}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 23641 / c2 {ECO:0000313|Proteomes:UP000009102};
RG US DOE Joint Genome Institute;
RA Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D.,
RA Goodwin L., Pitluck S., Davenport K., Brettin T., Detter J.C., Han C.,
RA Tapia R., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N.,
RA Kerfeld C., Cannon G., Heinhort S.;
RT "Complete sequence of Halothiobacillus neapolitanus c2.";
RL Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CP001801; ACX94934.1; -; Genomic_DNA.
DR AlphaFoldDB; D0KW07; -.
DR STRING; 555778.Hneap_0068; -.
DR KEGG; hna:Hneap_0068; -.
DR eggNOG; COG4258; Bacteria.
DR HOGENOM; CLU_017576_1_0_6; -.
DR OrthoDB; 9780358at2; -.
DR Proteomes; UP000009102; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR004869; MMPL_dom.
DR PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR PANTHER; PTHR33406:SF2; MEMBRANE PROTEIN SCO6666-RELATED; 1.
DR Pfam; PF03176; MMPL; 1.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000009102};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 266..282
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 289..310
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 316..337
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 364..384
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 390..409
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 438..456
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 666..684
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 691..711
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 717..736
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 748..767
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 773..795
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 190..415
FT /note="Membrane transport protein MMPL"
FT /evidence="ECO:0000259|Pfam:PF03176"
SQ SEQUENCE 804 AA; 85674 MW; D3673A30E1D56E1D CRC64;
MKHQGLEKMS WTERRLPVIG LWLLALALSL AVILHTRFTA DMSAFLPEHP TAAQAFLVDQ
IKDGAISRMI LIGIEGGDAA TRADASKALG NALRQSGLFT VVRNGDAPTR DQDKTLLFDH
RYLLSPDITP ERFTVAGLHE AIANGIDLLA SPFGMFSQTI FTRDPTAETF AIVGKLGQNT
GTDDAPRNQN GVWVSPDGKR SLMMLQTRAA GSDTDAMARA IEAVRADFSN AVKAHPDGSS
LRLLVSGAPV FSVDARALIK SDVERFSIIG SVAVMLLLLV VYRSFSMLVL GLLPVLTGIA
VAIATVSLGF GTVHGITIGF GTTLIGEAID YSIYYFIQTQ NAPKEGSAFR SAGRSEGMER
FWPTIRLGVL TSITGFAALL FSGFPGLAQI GLYSIAGLTT AALVTRFVLP HLGTARLNRH
SLAGIGRLLA PVFRAIQALR WGFVLLALAG FVLLVWRHDA IWQTGLSGLN PISGQAKAMD
DELRADMNAD DARYFIVAKA PTQQAALAAA ERIDAALEPL IKQGVLARFD SPAKFLPSVA
TQRVRQQALP DSTTLTERLD AAVQGLPISA SKLKPFVDAV EQARKQTPLT PADLEGTSFG
LAVSALLQKQ NGEWLTLIRL YVPSVGTLDT ARITAALKSS GISDALFVDK DAESSRLFNS
YLENTITLSL AGLLGIVILL GFVLRRPARL IRVLLPLLVA VVLVMAGLNL AGEKLNILNL
VGLLLIVAIG SNYALFFNQN TAPDHQTLAS LLLANLTTVI AFGTLAFSQL PILHAFGSTV
APGAFLALVV AAAFAKPNAP KAPA
//
