ID D0L6Q4_GORB4 Unreviewed; 1095 AA.
AC D0L6Q4;
DT 15-DEC-2009, integrated into UniProtKB/TrEMBL.
DT 15-DEC-2009, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE SubName: Full=Drug exporter of the RND superfamily-like protein {ECO:0000313|EMBL:ACY23614.1};
GN OrderedLocusNames=Gbro_4481 {ECO:0000313|EMBL:ACY23614.1};
OS Gordonia bronchialis (strain ATCC 25592 / DSM 43247 / BCRC 13721 / JCM 3198
OS / KCTC 3076 / NBRC 16047 / NCTC 10667) (Rhodococcus bronchialis).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Gordoniaceae;
OC Gordonia.
OX NCBI_TaxID=526226 {ECO:0000313|EMBL:ACY23614.1, ECO:0000313|Proteomes:UP000001219};
RN [1] {ECO:0000313|Proteomes:UP000001219}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25592 / DSM 43247 / BCRC 13721 / JCM 3198 / KCTC 3076 /
RC NBRC 16047 / NCTC 10667 {ECO:0000313|Proteomes:UP000001219};
RG US DOE Joint Genome Institute (JGI-PGF);
RA Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA Bruce D., Goodwin L., Pitluck S., Kyrpides N., Mavromatis K., Ivanova N.,
RA Ovchinnikova G., Saunders E., Brettin T., Detter J.C., Han C., Larimer F.,
RA Land M., Hauser L., Markowitz V., Cheng J.-F., Hugenholtz P., Woyke T.,
RA Wu D., Jando M., Schneider S., Goeker M., Klenk H.-P., Eisen J.A.;
RT "The complete chromosome of Gordonia bronchialis DSM 43247.";
RL Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ACY23614.1, ECO:0000313|Proteomes:UP000001219}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25592 / DSM 43247 / BCRC 13721 / JCM 3198 / KCTC 3076 /
RC NBRC 16047 / NCTC 10667 {ECO:0000313|Proteomes:UP000001219};
RX PubMed=21304674;
RA Ivanova N., Sikorski J., Jando M., Lapidus A., Nolan M., Lucas S.,
RA Del Rio T.G., Tice H., Copeland A., Cheng J.F., Chen F., Bruce D.,
RA Goodwin L., Pitluck S., Mavromatis K., Ovchinnikova G., Pati A., Chen A.,
RA Palaniappan K., Land M., Hauser L., Chang Y.J., Jeffries C.D., Chain P.,
RA Saunders E., Han C., Detter J.C., Brettin T., Rohde M., Goker M.,
RA Bristow J., Eisen J.A., Markowitz V., Hugenholtz P., Klenk H.P.,
RA Kyrpides N.C.;
RT "Complete genome sequence of Gordonia bronchialis type strain (3410).";
RL Stand. Genomic Sci. 2:19-28(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CP001802; ACY23614.1; -; Genomic_DNA.
DR RefSeq; WP_012836099.1; NC_013441.1.
DR AlphaFoldDB; D0L6Q4; -.
DR STRING; 526226.Gbro_4481; -.
DR KEGG; gbr:Gbro_4481; -.
DR eggNOG; COG2409; Bacteria.
DR HOGENOM; CLU_005108_8_0_11; -.
DR OrthoDB; 7051771at2; -.
DR Proteomes; UP000001219; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR004869; MMPL_dom.
DR InterPro; IPR000731; SSD.
DR PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR PANTHER; PTHR33406:SF2; MEMBRANE PROTEIN SCO6666-RELATED; 1.
DR Pfam; PF03176; MMPL; 2.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001219};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 12..32
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 202..230
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 250..272
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 293..317
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 329..351
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 415..437
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 574..596
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 603..622
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 637..661
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 688..708
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 225..350
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
FT REGION 798..1095
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 940..966
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 967..995
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1065..1079
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1095 AA; 116051 MW; 76CD2CA9D73DE3DD CRC64;
MFGAIGTFVY RMRFAVIAVM IALMAGLGLY GLDLGKHLSQ SGWFDPTSES VRGSQYADAA
LGRDHRSDII LLVTPPAGTT VDDPAFGAKV ETFVDDLIAA HPDIVNRQDP GVIDPFFKQS
VQSAVQERTF TADKKHAFIS IGVAGNDDTT VLNNYKTIEP FFHDIDDRFG LEGTTFELAG
LQPVAGSMAD GMDKDIHRAE VIALPIVAIM LFFIFGGVVA ACLPVLIGGL TIAGSLGIMK
ILALTTELNI FAQSVVTLIG LGIAIDYGLF IVSRFREELG EGYSTKAAVR RTVMTAGQTV
VFSATIIVAA LACLLIMPQG FLKSVAYGAI ASVTLAAILS ITVLPAILGI LGPRIDALSI
HTLMSWTVIP LVRKTLGAQR ADALDARFTG RIKSRQEIEN GFWGKLSGWV MKHPVATAVP
TVLLLLVLII PFGGIQFGGI SEKYLPPDNP NRVAQENFDK YFPTERTEEI KLVVVYDPNT
PDYDYKLQAI ADQANKIPGF TKPFSTSPND GAQSGQYPNS GAWIFQMSSG LQDRNTAAEA
IKDLRAINTG GLQMYVAGTP ALTQDSIDAL MSRLPLMAVL LVLVTGFLMF LAFGSIVLPI
KAALMSALGL GATLGILTWI FVDGHGAELA NFTPGPLFAA VLVLIIAIVF GLSTDYEIFL
LSRMVEARQK GASTTEAIRV GTAHTGRIIT AAAAILVVVT GAFGMSEIVM MKYIAYGMIA
ALILDATVIR MLLVPSVMKL LGDDCWWAPR WMRVMQQKIG LGETVLDDEP DELRDRSAAA
KTMSAGTLVA EAPTSVMARP RVARPASMGP PPERTAPARR AADRARTPEP TTVATERPTR
TRPPAETVPP AARPARGARV GPSAPPSGPQ PVGAGATSAP GGPPVTGDRP TPFRRPAARP
RSEGPDTGGW RLGDGGIRLA EPNSGRRPTD GVRTSLAPTT PPPTGRPATG PGPGGPSRPG
APQSRPSQPR SPQSGAPQPD SSHQGSSQPG SSQPGSPLRR RPELENTGGR PLAASLSPER
SGPSADRPRG SGDRMDRGLS PDAVPSADAT RTRDSDAAEP GQTGSRRSRT DRHARSDDGG
QISVQDLLRR SRSDS
//
