ID D0LGW1_HALO1 Unreviewed; 1821 AA.
AC D0LGW1;
DT 15-DEC-2009, integrated into UniProtKB/TrEMBL.
DT 15-DEC-2009, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=Alpha-2-macroglobulin domain protein {ECO:0000313|EMBL:ACY14683.1};
GN OrderedLocusNames=Hoch_2138 {ECO:0000313|EMBL:ACY14683.1};
OS Haliangium ochraceum (strain DSM 14365 / JCM 11303 / SMP-2).
OC Bacteria; Myxococcota; Polyangia; Haliangiales; Kofleriaceae; Haliangium.
OX NCBI_TaxID=502025 {ECO:0000313|EMBL:ACY14683.1, ECO:0000313|Proteomes:UP000001880};
RN [1] {ECO:0000313|EMBL:ACY14683.1, ECO:0000313|Proteomes:UP000001880}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 14365 / CIP 107738 / JCM 11303 / AJ 13395 / SMP-2
RC {ECO:0000313|Proteomes:UP000001880};
RX PubMed=21304682; DOI=10.4056/sigs.69.1277;
RG US DOE Joint Genome Institute (JGI-PGF);
RA Ivanova N., Daum C., Lang E., Abt B., Kopitz M., Saunders E., Lapidus A.,
RA Lucas S., Glavina Del Rio T., Nolan M., Tice H., Copeland A., Cheng J.F.,
RA Chen F., Bruce D., Goodwin L., Pitluck S., Mavromatis K., Pati A.,
RA Mikhailova N., Chen A., Palaniappan K., Land M., Hauser L., Chang Y.J.,
RA Jeffries C.D., Detter J.C., Brettin T., Rohde M., Goker M., Bristow J.,
RA Markowitz V., Eisen J.A., Hugenholtz P., Kyrpides N.C., Klenk H.P.;
RT "Complete genome sequence of Haliangium ochraceum type strain (SMP-2).";
RL Stand. Genomic Sci. 2:96-106(2010).
CC -!- SIMILARITY: Belongs to the protease inhibitor I39 (alpha-2-
CC macroglobulin) family. Bacterial alpha-2-macroglobulin subfamily.
CC {ECO:0000256|ARBA:ARBA00010556}.
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DR EMBL; CP001804; ACY14683.1; -; Genomic_DNA.
DR STRING; 502025.Hoch_2138; -.
DR KEGG; hoh:Hoch_2138; -.
DR eggNOG; COG2373; Bacteria.
DR HOGENOM; CLU_002018_0_0_7; -.
DR Proteomes; UP000001880; Chromosome.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:InterPro.
DR CDD; cd02891; A2M_like; 1.
DR Gene3D; 1.50.10.20; -; 1.
DR Gene3D; 2.60.40.1930; -; 1.
DR Gene3D; 2.60.40.3710; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR011625; A2M_N_BRD.
DR InterPro; IPR047565; Alpha-macroglob_thiol-ester_cl.
DR InterPro; IPR011626; Alpha-macroglobulin_TED.
DR InterPro; IPR021868; Alpha_2_Macroglob_MG3.
DR InterPro; IPR041203; Bact_A2M_MG5.
DR InterPro; IPR041462; Bact_A2M_MG6.
DR InterPro; IPR041246; Bact_MG10.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR001599; Macroglobln_a2.
DR InterPro; IPR002890; MG2.
DR InterPro; IPR032812; SbsA_Ig.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR PANTHER; PTHR40094; ALPHA-2-MACROGLOBULIN HOMOLOG; 1.
DR PANTHER; PTHR40094:SF1; UBIQUITIN DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00207; A2M; 1.
DR Pfam; PF07703; A2M_BRD; 1.
DR Pfam; PF13205; Big_5; 1.
DR Pfam; PF17973; bMG10; 1.
DR Pfam; PF11974; bMG3; 1.
DR Pfam; PF17972; bMG5; 1.
DR Pfam; PF17962; bMG6; 1.
DR Pfam; PF01835; MG2; 1.
DR Pfam; PF07678; TED_complement; 1.
DR SMART; SM01360; A2M; 1.
DR SMART; SM01359; A2M_N_2; 1.
DR SMART; SM01419; Thiol-ester_cl; 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001880};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 936..1084
FT /note="Alpha-2-macroglobulin bait region"
FT /evidence="ECO:0000259|SMART:SM01359"
FT DOMAIN 1143..1233
FT /note="Alpha-2-macroglobulin"
FT /evidence="ECO:0000259|SMART:SM01360"
SQ SEQUENCE 1821 AA; 197387 MW; C502412DCB2B8F6B CRC64;
MELAVKRFGI FVAILAALGC GCGADAPSDL SASGTPSGEV AELLEVVVSF SRPMVAESAL
DEPLDKAPLR IAPEIAGEMH WRDASTLVFV ATTNLPASTE FTATVPAGTA ALDGNQLAEP
YSFTFTSERL AGSMEVVGSA ERARADQQIK LTFNQEVAFD QVREHCHYAA HGKAIPVVLA
PDTSDGPAKS YLVTPAEELA LDTEWTLLCK ADLRGTQGKL SMAAAASQRF HTYGPLEFVA
MTPEGKDLVP DEGLRLELAF NNPLAKPYAI SLKPAAPGFP ERCHMAGEVP PALSCPAILE
PNTSYTLTVD GAQTDIFGQT LGESVTLPLR TSNAKPTVSM EAGYFVAELK RPVYPLWLRN
VSKLKVRAAA VTPANFHELR PLLDWWTSDA AKLKGTSLRA QSKDVTLELE ENKWHQYPLD
PSEFFGGQPG PGMYYFEVGA PEVESGGFWN GGYKKVLISF TDIGVVTKVG GARGLVWATQ
LSTGKPLAGA KVTVRAGGKV TWNGTTDAEG VAVLPPRDSL TGTGEQGGSL NVYVSKGDDW
TMVDPERTGS LSAWNFNVSP SWNHSSVRMR GFMHSDRGLY RPGDTVHVKG LARTSQLGAP
LAVPSEKRAK LTVRGPRGDE LLTREVPISD FGGFWTDIEM PSDARLGDYS VRAEMEHGSF
STSFAVEEYR AASFEVTGKS ETKRLVRRGS LEAKVSANYF YGAPVRDAQA TFTVHSRPRS
VSFPEHEQFS FGDDRRYDSY RYYPDYSQTL ITEVQARLDS DGNGSLSVPL TPSDVSGDAD
LLVRASVTAP SNEVINDSFL VPYFRARRYH GIKSEGGYFL EVGKKRRFEV MAVSPAGKPV
AGDVQVTVQR RDWNCLWEDW GYRGSYRCNE IKHDVLSTSV KMQENAPGSF EFTPEGGGEY
WIIVEGERDN HASAAMRMYA WGDGGGSWRS DDTMSFDLLS DKKEYRVGDT ATLLLQTDLS
EGSGLVTIER DGVIESRPFE LSPTNKHIKV PILDSYAPNV YVSVALVQGR MGEGPRGMPR
MRMGLTNLRV RPEGNVLKVA VQTARPDYRP GERVEATVTV TDASGAPVSA EVAITAADEG
VLSLIDYETP NPTPTFYSPW GLAVETSTQY QYLKDIAAPN LERPATGGDA GGPGSLRARF
LASAVWKPGV VTDSAGKATV SFDAPDNLTA FRVMAVAADR GQRFGSGDKR FTVSKPLQLH
RSLPRFLTLG DTLQGGVVVH NETGKAGRAT VELKTNDALA LSGSAQQTVD VPAGGRVPVL
FAIEAMNPGN AELTFSVRMD KERDDVRFEL PVHHASPERK LSVARGDTKG EERIAIELPD
HAIASTAVLS VSVDPDGLAG IEEGLQSLIR YPYGCLEQTT SKVIPIIAVR ELAEALQLEG
LSGAEIDEFV TAGVGKIGRH QNPDGGYALW PGNDSETYYT AYALWGLHLA KQAGYAVEDS
RIREGLSYLR YNAEGQDDGP HYSAAGDFGS RAFALYVRAM LGDADPQAVT RLAEESAMPV
YGRAFLARAL AASVGAKGAG VSAMVADLRA KAEAAAQRGE LIEESQDDEL DWYMSNSVRT
TAIVLEALIA LDPKAPVIKK LVASLMKARR ARPYFSTQDN LYTLLALSSY ARSMSGAPPS
VTVMLGDDTL IAGKLGGKLR IRVATAQLRA RQATLSIRAQ GEVHYAVDLR YRQKPETLDT
VSEVLALERV YLDDSGAPKS SFQVGDVFKV KLSTPIDKRR THLMISDRLP AGFEALNARL
ATVGSEGRVE QRRTWGTHRE LRDERADFSA EYVSEGAYVR EYMVRVIAAG RFAVPPAVAE
LMYEPEVHAQ TALTHIDIAA R
//
