ID D0LT26_HALO1 Unreviewed; 793 AA.
AC D0LT26;
DT 15-DEC-2009, integrated into UniProtKB/TrEMBL.
DT 15-DEC-2009, sequence version 1.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=3-hydroxyacyl-CoA dehydrogenase NAD-binding protein {ECO:0000313|EMBL:ACY19162.1};
GN OrderedLocusNames=Hoch_6697 {ECO:0000313|EMBL:ACY19162.1};
OS Haliangium ochraceum (strain DSM 14365 / JCM 11303 / SMP-2).
OC Bacteria; Myxococcota; Polyangia; Haliangiales; Kofleriaceae; Haliangium.
OX NCBI_TaxID=502025 {ECO:0000313|EMBL:ACY19162.1, ECO:0000313|Proteomes:UP000001880};
RN [1] {ECO:0000313|EMBL:ACY19162.1, ECO:0000313|Proteomes:UP000001880}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 14365 / CIP 107738 / JCM 11303 / AJ 13395 / SMP-2
RC {ECO:0000313|Proteomes:UP000001880};
RX PubMed=21304682; DOI=10.4056/sigs.69.1277;
RG US DOE Joint Genome Institute (JGI-PGF);
RA Ivanova N., Daum C., Lang E., Abt B., Kopitz M., Saunders E., Lapidus A.,
RA Lucas S., Glavina Del Rio T., Nolan M., Tice H., Copeland A., Cheng J.F.,
RA Chen F., Bruce D., Goodwin L., Pitluck S., Mavromatis K., Pati A.,
RA Mikhailova N., Chen A., Palaniappan K., Land M., Hauser L., Chang Y.J.,
RA Jeffries C.D., Detter J.C., Brettin T., Rohde M., Goker M., Bristow J.,
RA Markowitz V., Eisen J.A., Hugenholtz P., Kyrpides N.C., Klenk H.P.;
RT "Complete genome sequence of Haliangium ochraceum type strain (SMP-2).";
RL Stand. Genomic Sci. 2:96-106(2010).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) +
CC NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378, ChEBI:CHEBI:57318,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:90726; EC=1.1.1.35;
CC Evidence={ECO:0000256|ARBA:ARBA00023693};
CC -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC {ECO:0000256|ARBA:ARBA00005005}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP001804; ACY19162.1; -; Genomic_DNA.
DR RefSeq; WP_012831754.1; NC_013440.1.
DR AlphaFoldDB; D0LT26; -.
DR STRING; 502025.Hoch_6697; -.
DR KEGG; hoh:Hoch_6697; -.
DR eggNOG; COG1024; Bacteria.
DR eggNOG; COG1250; Bacteria.
DR HOGENOM; CLU_010448_0_0_7; -.
DR OrthoDB; 5389341at2; -.
DR UniPathway; UPA00659; -.
DR Proteomes; UP000001880; Chromosome.
DR GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR CDD; cd06558; crotonase-like; 1.
DR Gene3D; 1.10.1040.50; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR PANTHER; PTHR48075:SF7; 3-HYDROXYACYL-COA DEHYDROGENASE-RELATED; 1.
DR Pfam; PF00725; 3HCDH; 1.
DR Pfam; PF02737; 3HCDH_N; 1.
DR Pfam; PF00378; ECH_1; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Reference proteome {ECO:0000313|Proteomes:UP000001880}.
FT DOMAIN 12..202
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 206..305
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
SQ SEQUENCE 793 AA; 86302 MW; B3F561BC6F2B49F0 CRC64;
MSKTSQEPIR RIAVLGAGVM GSGIAAHVAN ASLPVLLLDI VPPKLSDDER KSKSARDAIA
AGALKAMGKA RPAPFFHPDN ARLVSIGNFE DDLDKLAECD LVIEAIIERL DIKRGLFEKL
DKIVSGDTII ASNTSGLRIS EMLEGRSERF RKNFLVMHFF NPPRYMKLLE LVAGPDTDPA
AMKRVSDFGR EVLGKGIVVA KDAPNFVANR IGTHAMMGSL HLMQEMGLSP EDLDQITGVP
MGHPKSATLR TADMVGLDTL VHVVENCHAS LTEDEDREVF TVPEFVRGMV ERKQLGNKTK
GGFYRKTKAG IETFDPSTGE YRPRAGDEAI KKTCKNIAKD ADPRSRVRKL VAAEGKVGEF
AWKALSRSLA YTARRVGEIA DDIDAIDNGM KWGYNWELGP FETWDALGFA ETVDRMKAEG
IELPESVLKM RESGASGFYD GDRVYDLQRG EYVQRTPDPR EVKLEIMRRG EAPVLKTRGG
EAWDLGDGVL GVTFGTKANS IDADVIQLLH ESVSKAESEF RGVLIANQGD HFCVGANLFM
VVMAAQQKKW DDIKQMTQRL QEAGQRMKYA TVPVVAAPFG MALGGGLEVC LASDAVQAAA
ETYAGLVEVG VGLIPAGGGC MNLVWRALES IPDGVEYDAS AFVVQVFKNI ALAEVATSAG
AAKRKGYFRH SDGISFDRAR QLHEAKQRVI GMADAGYHAP LKRSYKLPGE SGIATLELMV
STLVAGGYAS EHDAKIASKL AAILCGGVSG ASRYVSEEDV LELEREAFVS LCGEPKSQER
MQHMLMHNKP LRN
//