ID D0LVD7_HALO1 Unreviewed; 860 AA.
AC D0LVD7;
DT 15-DEC-2009, integrated into UniProtKB/TrEMBL.
DT 15-DEC-2009, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN OrderedLocusNames=Hoch_5009 {ECO:0000313|EMBL:ACY17498.1};
OS Haliangium ochraceum (strain DSM 14365 / JCM 11303 / SMP-2).
OC Bacteria; Myxococcota; Polyangia; Haliangiales; Kofleriaceae; Haliangium.
OX NCBI_TaxID=502025 {ECO:0000313|EMBL:ACY17498.1, ECO:0000313|Proteomes:UP000001880};
RN [1] {ECO:0000313|EMBL:ACY17498.1, ECO:0000313|Proteomes:UP000001880}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 14365 / CIP 107738 / JCM 11303 / AJ 13395 / SMP-2
RC {ECO:0000313|Proteomes:UP000001880};
RX PubMed=21304682; DOI=10.4056/sigs.69.1277;
RG US DOE Joint Genome Institute (JGI-PGF);
RA Ivanova N., Daum C., Lang E., Abt B., Kopitz M., Saunders E., Lapidus A.,
RA Lucas S., Glavina Del Rio T., Nolan M., Tice H., Copeland A., Cheng J.F.,
RA Chen F., Bruce D., Goodwin L., Pitluck S., Mavromatis K., Pati A.,
RA Mikhailova N., Chen A., Palaniappan K., Land M., Hauser L., Chang Y.J.,
RA Jeffries C.D., Detter J.C., Brettin T., Rohde M., Goker M., Bristow J.,
RA Markowitz V., Eisen J.A., Hugenholtz P., Kyrpides N.C., Klenk H.P.;
RT "Complete genome sequence of Haliangium ochraceum type strain (SMP-2).";
RL Stand. Genomic Sci. 2:96-106(2010).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
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DR EMBL; CP001804; ACY17498.1; -; Genomic_DNA.
DR RefSeq; WP_012830090.1; NC_013440.1.
DR AlphaFoldDB; D0LVD7; -.
DR STRING; 502025.Hoch_5009; -.
DR REBASE; 22285; M.HocORF5009P.
DR KEGG; hoh:Hoch_5009; -.
DR eggNOG; COG0286; Bacteria.
DR HOGENOM; CLU_013049_4_0_7; -.
DR Proteomes; UP000001880; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR GO; GO:0009307; P:DNA restriction-modification system; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1260.30; -; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR022749; D12N6_MeTrfase_N.
DR InterPro; IPR003356; DNA_methylase_A-5.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR038333; T1MK-like_N_sf.
DR PANTHER; PTHR42933; SLR6095 PROTEIN; 1.
DR PANTHER; PTHR42933:SF3; TYPE I RESTRICTION ENZYME MJAVIII METHYLASE SUBUNIT; 1.
DR Pfam; PF12161; HsdM_N; 1.
DR Pfam; PF02384; N6_Mtase; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:ACY17498.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001880};
KW Restriction system {ECO:0000256|ARBA:ARBA00022747};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:ACY17498.1}.
FT DOMAIN 27..165
FT /note="N6 adenine-specific DNA methyltransferase N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF12161"
FT DOMAIN 178..487
FT /note="DNA methylase adenine-specific"
FT /evidence="ECO:0000259|Pfam:PF02384"
FT REGION 598..627
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 606..626
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 860 AA; 94219 MW; 4D6940C757B1A519 CRC64;
MTDTTRRHTD EHRDALEAQQ PLTLGQLERH LYAAADILRG KMDASEFKEY IFGMLFIKRC
SDEFEARREE ILAEQQAAGA SAEAAALAAE QPERYARSFF VPPSARWAQV SALERDLGTG
LNAALAALED TNPALHGVLR HIDFNRTVGK SRMPDKRLRA LVAHFGRHRL RNRDFEFSDM
LGAAYEYLIG EFADSAGKKG GEFYTPRPVV RLIVRLSDPR PGMRVYDPCS GSGGMLILAR
QYVQEHGGDA GSLGLYGQED NGGVWTISQM NMLLHGVSDA DIRNGDTLHE PLHIDPASGE
LLRFDRIITN PPFAQNYSPD ELPLPERFRF GMCPHAGKKA DWMYAQHMLA ALAPGGMAVT
VMPHGVLFRG GVEQAIRSRV LEADLVEAVI GLPPNLFYGT SIPACVLVLR APEAKPPERQ
GRVLFVDASD EFHAARAQNH LQPEHVEKIA TAFERFAEVP GYASVVSVDE ILAAGGNLNI
RSYVSRAAAP TGYDVRGLIE GGVPRAEVEA ERARFAAVGL DLGSVLRLQG GGLSYWFADG
ISQRRDLRAA VDGDLRVRSA HVDMLARTDA WWAAHRWVLE SLADARAGAV ADSDAGAVAD
PDAGVERGRG GQRKGGARKR GRGDQAGACR GGEVAFLRVR RCFVDSFRDA LSPAGVLAPQ
DLAGIAAGFW GSLELELKIL MTRGFAGLLY SWIKVLVRDD KPSARGQAEL GHIEVAAPSL
DIVGRLLTEA GQADHELRAL EEGAAHSAEE LDGDAQAQLV GELTHLRKRR TRTRAQVLAC
LRAAQGRMRE DECRELVIGL LQDQLIWKLE EALRGLRADL TAQLERWWDA YHVPLRALER
ERDRAASELE TALRGLGYVG
//
