ID D0MVW7_PHYIT Unreviewed; 1039 AA.
AC D0MVW7;
DT 15-DEC-2009, integrated into UniProtKB/TrEMBL.
DT 15-DEC-2009, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE RecName: Full=alpha-1,2-Mannosidase {ECO:0000256|RuleBase:RU361193};
DE EC=3.2.1.- {ECO:0000256|RuleBase:RU361193};
GN ORFNames=PITG_02266 {ECO:0000313|EMBL:EEY63780.1};
OS Phytophthora infestans (strain T30-4) (Potato late blight agent).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=403677 {ECO:0000313|EMBL:EEY63780.1, ECO:0000313|Proteomes:UP000006643};
RN [1] {ECO:0000313|Proteomes:UP000006643}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=T30-4 {ECO:0000313|Proteomes:UP000006643};
RX PubMed=19741609; DOI=10.1038/nature08358;
RG The Broad Institute Genome Sequencing Platform;
RA Haas B.J., Kamoun S., Zody M.C., Jiang R.H., Handsaker R.E., Cano L.M.,
RA Grabherr M., Kodira C.D., Raffaele S., Torto-Alalibo T., Bozkurt T.O.,
RA Ah-Fong A.M., Alvarado L., Anderson V.L., Armstrong M.R., Avrova A.,
RA Baxter L., Beynon J., Boevink P.C., Bollmann S.R., Bos J.I., Bulone V.,
RA Cai G., Cakir C., Carrington J.C., Chawner M., Conti L., Costanzo S.,
RA Ewan R., Fahlgren N., Fischbach M.A., Fugelstad J., Gilroy E.M., Gnerre S.,
RA Green P.J., Grenville-Briggs L.J., Griffith J., Grunwald N.J., Horn K.,
RA Horner N.R., Hu C.H., Huitema E., Jeong D.H., Jones A.M., Jones J.D.,
RA Jones R.W., Karlsson E.K., Kunjeti S.G., Lamour K., Liu Z., Ma L.,
RA Maclean D., Chibucos M.C., McDonald H., McWalters J., Meijer H.J.,
RA Morgan W., Morris P.F., Munro C.A., O'Neill K., Ospina-Giraldo M.,
RA Pinzon A., Pritchard L., Ramsahoye B., Ren Q., Restrepo S., Roy S.,
RA Sadanandom A., Savidor A., Schornack S., Schwartz D.C., Schumann U.D.,
RA Schwessinger B., Seyer L., Sharpe T., Silvar C., Song J., Studholme D.J.,
RA Sykes S., Thines M., van de Vondervoort P.J., Phuntumart V., Wawra S.,
RA Weide R., Win J., Young C., Zhou S., Fry W., Meyers B.C., van West P.,
RA Ristaino J., Govers F., Birch P.R., Whisson S.C., Judelson H.S.,
RA Nusbaum C.;
RT "Genome sequence and analysis of the Irish potato famine pathogen
RT Phytophthora infestans.";
RL Nature 461:393-398(2009).
CC -!- COFACTOR:
CC Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC Evidence={ECO:0000256|PIRSR:PIRSR601382-2};
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 47 family.
CC {ECO:0000256|ARBA:ARBA00007658, ECO:0000256|RuleBase:RU361193}.
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DR EMBL; DS028120; EEY63780.1; -; Genomic_DNA.
DR RefSeq; XP_002907216.1; XM_002907170.1.
DR AlphaFoldDB; D0MVW7; -.
DR STRING; 403677.D0MVW7; -.
DR EnsemblProtists; PITG_02266T0; PITG_02266T0; PITG_02266.
DR GeneID; 9469654; -.
DR KEGG; pif:PITG_02266; -.
DR VEuPathDB; FungiDB:PITG_02266; -.
DR eggNOG; KOG2429; Eukaryota.
DR HOGENOM; CLU_281121_0_0_1; -.
DR InParanoid; D0MVW7; -.
DR OMA; WHYEWCF; -.
DR OrthoDB; 942598at2759; -.
DR Proteomes; UP000006643; Partially assembled WGS sequence.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0004571; F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR CDD; cd04818; PA_subtilisin_1; 1.
DR Gene3D; 1.50.10.10; -; 1.
DR Gene3D; 3.50.30.30; -; 1.
DR Gene3D; 2.70.130.10; Mannose-6-phosphate receptor binding domain; 1.
DR InterPro; IPR012341; 6hp_glycosidase-like_sf.
DR InterPro; IPR044674; EDEM1/2/3.
DR InterPro; IPR001382; Glyco_hydro_47.
DR InterPro; IPR009011; Man6P_isomerase_rcpt-bd_dom_sf.
DR InterPro; IPR012913; OS9-like_dom.
DR InterPro; IPR046450; PA_dom_sf.
DR InterPro; IPR003137; PA_domain.
DR InterPro; IPR036026; Seven-hairpin_glycosidases.
DR PANTHER; PTHR45679; ER DEGRADATION-ENHANCING ALPHA-MANNOSIDASE-LIKE PROTEIN 2; 1.
DR PANTHER; PTHR45679:SF6; ER DEGRADATION-ENHANCING ALPHA-MANNOSIDASE-LIKE PROTEIN 2; 1.
DR Pfam; PF01532; Glyco_hydro_47; 1.
DR Pfam; PF02225; PA; 1.
DR Pfam; PF07915; PRKCSH; 1.
DR PRINTS; PR00747; GLYHDRLASE47.
DR SUPFAM; SSF52025; PA domain; 1.
DR SUPFAM; SSF48225; Seven-hairpin glycosidases; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|PIRSR:PIRSR601382-2};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Glycosidase {ECO:0000256|RuleBase:RU361193};
KW Hydrolase {ECO:0000256|RuleBase:RU361193};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR601382-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000006643}.
FT DOMAIN 5..87
FT /note="Protein OS9-like"
FT /evidence="ECO:0000259|Pfam:PF07915"
FT DOMAIN 928..1016
FT /note="PA"
FT /evidence="ECO:0000259|Pfam:PF02225"
FT REGION 1018..1039
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 241
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR601382-1"
FT ACT_SITE 382
FT /evidence="ECO:0000256|PIRSR:PIRSR601382-1"
FT ACT_SITE 480
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR601382-1"
FT ACT_SITE 505
FT /evidence="ECO:0000256|PIRSR:PIRSR601382-1"
FT BINDING 589
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR601382-2"
SQ SEQUENCE 1039 AA; 115882 MW; 4F9C1240B82A5036 CRC64;
MRGEKCLRYH VAGTWWHYEW CFDRHVRQFH PLPKGENTKE NSIMLGVFNP QKPEPLRVLA
VDNLARLADP DRMGYMAHQR YNSGDFCEAR EARRSVKLQV KCCALHDNET YVDSVDEKAP
CDYEMNVCSP VACGLMQRDQ FVLTAPTSME EDERKALTKT VRDMFYHAYN GYLTHAFPQD
DLLPLSCKGG EFELGRLPML TLIDTLDTLA LLQDATEFRR AVGLVVENAD FDLDTEVSVF
ETTIRMLGGL LSAHLFAVNT QLKLYPDGDY DDALLRLAVD LGDRLMPAFD TVTGIPYGTV
NLKYGVPKGE TPIASTAGAG SLSVEFTMLS VLTGEPRYAT ASRGAVRALF QRRSKLGLLG
KHINTKTGEW TETSSGPGSN SDSFYEYLMK MYELFGDREA LEMFAQVYPA VLVHNKHGDW
YTDVSMYTGC HHHSGSSAII FESLASFWPG MQVAAGDLQV AAESMNAFYR VWRDYGFLSE
QFNVGDWKPV KSRGGGGARY PLRPELIEST FYMHEATNDS SWLRAGAHVV HSLQKYTKTS
CGYASIADVE SKKQEDLMPS FFLSETCKYL YLLFNTTHFF RQGNYVMTTE AHPLPILPTK
LVEPILRASD ASSDVLNHNR YSPDRVMQCR VPKFYDLVDY SIHYEGKVVA RTSRCVPPAP
SPAKLLKASK AVAEKLAAAS TETSSLSDIE KIAMAASDNA KPTTTKEKKS DTGSVTSDVL
QEWLPSLQKK LQTIGGKNFD NMWLEKLLEE SSATSKKQPV SEQGGQAVQY LYGGNQLGEF
RVEQLPGSVR VTREETGDWI EASGVHDANH MIVGLGFNDG SDGDAGADSY TFDEPKSDKI
HVEQGDDYQP PFMAWNYVYK VNEDLTLPMD QRCSLRVQVG YTPYPGELQH NPHEAKGKPN
VWLTVPCVGA GFGVTSTFKA SRAFPHSELV LADPFDACSD VSNLTEEHVR GKIVLVVRGE
CFFEKKARNA AHWGAAGVIV VNTEDDDLVM VMGGLEENSE EAIDEPLDIP VVMVPQRLED
HEESTETDRS LEWMAELTT
//