ID D0MWM7_PHYIT Unreviewed; 748 AA.
AC D0MWM7;
DT 15-DEC-2009, integrated into UniProtKB/TrEMBL.
DT 15-DEC-2009, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=tRNA (Cytosine-5-)-methyltransferase NSUN2-like protein {ECO:0000313|EMBL:EEY64040.1};
GN ORFNames=PITG_02560 {ECO:0000313|EMBL:EEY64040.1};
OS Phytophthora infestans (strain T30-4) (Potato late blight agent).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=403677 {ECO:0000313|EMBL:EEY64040.1, ECO:0000313|Proteomes:UP000006643};
RN [1] {ECO:0000313|Proteomes:UP000006643}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=T30-4 {ECO:0000313|Proteomes:UP000006643};
RX PubMed=19741609; DOI=10.1038/nature08358;
RG The Broad Institute Genome Sequencing Platform;
RA Haas B.J., Kamoun S., Zody M.C., Jiang R.H., Handsaker R.E., Cano L.M.,
RA Grabherr M., Kodira C.D., Raffaele S., Torto-Alalibo T., Bozkurt T.O.,
RA Ah-Fong A.M., Alvarado L., Anderson V.L., Armstrong M.R., Avrova A.,
RA Baxter L., Beynon J., Boevink P.C., Bollmann S.R., Bos J.I., Bulone V.,
RA Cai G., Cakir C., Carrington J.C., Chawner M., Conti L., Costanzo S.,
RA Ewan R., Fahlgren N., Fischbach M.A., Fugelstad J., Gilroy E.M., Gnerre S.,
RA Green P.J., Grenville-Briggs L.J., Griffith J., Grunwald N.J., Horn K.,
RA Horner N.R., Hu C.H., Huitema E., Jeong D.H., Jones A.M., Jones J.D.,
RA Jones R.W., Karlsson E.K., Kunjeti S.G., Lamour K., Liu Z., Ma L.,
RA Maclean D., Chibucos M.C., McDonald H., McWalters J., Meijer H.J.,
RA Morgan W., Morris P.F., Munro C.A., O'Neill K., Ospina-Giraldo M.,
RA Pinzon A., Pritchard L., Ramsahoye B., Ren Q., Restrepo S., Roy S.,
RA Sadanandom A., Savidor A., Schornack S., Schwartz D.C., Schumann U.D.,
RA Schwessinger B., Seyer L., Sharpe T., Silvar C., Song J., Studholme D.J.,
RA Sykes S., Thines M., van de Vondervoort P.J., Phuntumart V., Wawra S.,
RA Weide R., Win J., Young C., Zhou S., Fry W., Meyers B.C., van West P.,
RA Ristaino J., Govers F., Birch P.R., Whisson S.C., Judelson H.S.,
RA Nusbaum C.;
RT "Genome sequence and analysis of the Irish potato famine pathogen
RT Phytophthora infestans.";
RL Nature 461:393-398(2009).
CC -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC superfamily. RsmB/NOP family. {ECO:0000256|PROSITE-ProRule:PRU01023}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU01023}.
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DR EMBL; DS028120; EEY64040.1; -; Genomic_DNA.
DR RefSeq; XP_002907476.1; XM_002907430.1.
DR AlphaFoldDB; D0MWM7; -.
DR STRING; 403677.D0MWM7; -.
DR EnsemblProtists; PITG_02560T0; PITG_02560T0; PITG_02560.
DR GeneID; 9470169; -.
DR KEGG; pif:PITG_02560; -.
DR VEuPathDB; FungiDB:PITG_02560; -.
DR eggNOG; KOG2198; Eukaryota.
DR HOGENOM; CLU_005316_4_3_1; -.
DR InParanoid; D0MWM7; -.
DR OMA; PERWRTW; -.
DR OrthoDB; 197651at2759; -.
DR Proteomes; UP000006643; Partially assembled WGS sequence.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008173; F:RNA methyltransferase activity; IEA:InterPro.
DR GO; GO:0001510; P:RNA methylation; IEA:InterPro.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR049560; MeTrfase_RsmB-F_NOP2_cat.
DR InterPro; IPR001678; MeTrfase_RsmB-F_NOP2_dom.
DR InterPro; IPR023267; RCMT.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR22808; NCL1 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR22808:SF1; RNA CYTOSINE C(5)-METHYLTRANSFERASE NSUN2; 1.
DR Pfam; PF01189; Methyltr_RsmB-F; 1.
DR PRINTS; PR02008; RCMTFAMILY.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS51686; SAM_MT_RSMB_NOP; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603, ECO:0000256|PROSITE-
KW ProRule:PRU01023}; Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000006643};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU01023};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW ECO:0000256|PROSITE-ProRule:PRU01023};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PROSITE-
KW ProRule:PRU01023}.
FT DOMAIN 145..510
FT /note="SAM-dependent MTase RsmB/NOP-type"
FT /evidence="ECO:0000259|PROSITE:PS51686"
FT REGION 1..68
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 81..105
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 22..41
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 305
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01023"
SQ SEQUENCE 748 AA; 82699 MW; D585631E4BBF6E92 CRC64;
MGGKSRAAMR REKKRKQKGA SSTSLDDVAA VTASGKPQKR QQKTIYDSDS DSSDDTNRAA
AIPLPSLEDG DKVRDFVKEL ETQHKPTGKR ARAEAEQHAV DQRKKRFREE KAEKIVWRKF
DRENRAFEKF YERCLGLDKD EFARFLACLK EPLPVHLRVN GNYTSLSEIV TGSLELDFDL
REVTVPTPVG GGEMHVQFGP EAWAPEKRLW KLSVDSKMFR KVEGLRSLST YVRAQGSLGT
LLRQDPAATV LPAFLDVQPG QRVLDLCGGG EHRAPIVKEY LCPGSPASAG IETSSSAKNV
LVVNERDATV AASAVRNLTR TLPLACDLIV SAHKPEDFPV PGIADALFDR VICCAPCSGD
GLIRKLPEKW RTWSPEQALV HHPSQLGLAE HAVSLLRTGG ALLYSTRSLN PIENEAVVAE
LLRRSNGALE LVETDDILEG LERSHGLSQW DVLDLASWDD ASEDQRHRLR PSMWPPSNEE
CDEMHLDRCV RLLPHQNDTH GLFLAVIRKT READNAVVAV GPALPQSKTK TKSNVSKNKK
QAKAEKPFGS FTPIGQEHLA SIRSFFALRS SSAFLERANM ARQKRAVHVV TPAVAELVTN
QLRGRLSIYH AGVFALRPGT GVEAVADELT DDGARTLLPE MNKRVLNLPQ DEFTSFLESR
EMWLKNAGEH AREQLAQMTE GSLAVALDDM EPAQTGDRDI VLVAVKRHNS CSIVSSPAAI
ARIKALLEEL NDTGGDEDGY DSFEFEDE
//
