ID D0N080_PHYIT Unreviewed; 4083 AA.
AC D0N080;
DT 15-DEC-2009, integrated into UniProtKB/TrEMBL.
DT 15-DEC-2009, sequence version 1.
DT 24-JAN-2024, entry version 84.
DE SubName: Full=Dynein heavy chain {ECO:0000313|EMBL:EEY65893.1};
GN ORFNames=PITG_03423 {ECO:0000313|EMBL:EEY65893.1};
OS Phytophthora infestans (strain T30-4) (Potato late blight agent).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=403677 {ECO:0000313|EMBL:EEY65893.1, ECO:0000313|Proteomes:UP000006643};
RN [1] {ECO:0000313|Proteomes:UP000006643}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=T30-4 {ECO:0000313|Proteomes:UP000006643};
RX PubMed=19741609; DOI=10.1038/nature08358;
RG The Broad Institute Genome Sequencing Platform;
RA Haas B.J., Kamoun S., Zody M.C., Jiang R.H., Handsaker R.E., Cano L.M.,
RA Grabherr M., Kodira C.D., Raffaele S., Torto-Alalibo T., Bozkurt T.O.,
RA Ah-Fong A.M., Alvarado L., Anderson V.L., Armstrong M.R., Avrova A.,
RA Baxter L., Beynon J., Boevink P.C., Bollmann S.R., Bos J.I., Bulone V.,
RA Cai G., Cakir C., Carrington J.C., Chawner M., Conti L., Costanzo S.,
RA Ewan R., Fahlgren N., Fischbach M.A., Fugelstad J., Gilroy E.M., Gnerre S.,
RA Green P.J., Grenville-Briggs L.J., Griffith J., Grunwald N.J., Horn K.,
RA Horner N.R., Hu C.H., Huitema E., Jeong D.H., Jones A.M., Jones J.D.,
RA Jones R.W., Karlsson E.K., Kunjeti S.G., Lamour K., Liu Z., Ma L.,
RA Maclean D., Chibucos M.C., McDonald H., McWalters J., Meijer H.J.,
RA Morgan W., Morris P.F., Munro C.A., O'Neill K., Ospina-Giraldo M.,
RA Pinzon A., Pritchard L., Ramsahoye B., Ren Q., Restrepo S., Roy S.,
RA Sadanandom A., Savidor A., Schornack S., Schwartz D.C., Schumann U.D.,
RA Schwessinger B., Seyer L., Sharpe T., Silvar C., Song J., Studholme D.J.,
RA Sykes S., Thines M., van de Vondervoort P.J., Phuntumart V., Wawra S.,
RA Weide R., Win J., Young C., Zhou S., Fry W., Meyers B.C., van West P.,
RA Ristaino J., Govers F., Birch P.R., Whisson S.C., Judelson H.S.,
RA Nusbaum C.;
RT "Genome sequence and analysis of the Irish potato famine pathogen
RT Phytophthora infestans.";
RL Nature 461:393-398(2009).
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DR EMBL; DS028121; EEY65893.1; -; Genomic_DNA.
DR RefSeq; XP_002906492.1; XM_002906446.1.
DR STRING; 403677.D0N080; -.
DR EnsemblProtists; PITG_03423T0; PITG_03423T0; PITG_03423.
DR GeneID; 9467387; -.
DR KEGG; pif:PITG_03423; -.
DR VEuPathDB; FungiDB:PITG_03423; -.
DR eggNOG; KOG0379; Eukaryota.
DR eggNOG; KOG3595; Eukaryota.
DR HOGENOM; CLU_000038_4_1_1; -.
DR InParanoid; D0N080; -.
DR OMA; ITMDAHG; -.
DR OrthoDB; 312149at2759; -.
DR Proteomes; UP000006643; Partially assembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR CDD; cd00102; IPT; 1.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR Gene3D; 2.120.10.80; Kelch-type beta propeller; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR017868; Filamin/ABP280_repeat-like.
DR InterPro; IPR001298; Filamin/ABP280_rpt.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR015915; Kelch-typ_b-propeller.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR PANTHER; PTHR45703:SF8; DYNEINS HEAVY CHAIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF00630; Filamin; 1.
DR Pfam; PF13415; Kelch_3; 1.
DR Pfam; PF12777; MT; 1.
DR Pfam; PF01833; TIG; 1.
DR SMART; SM00382; AAA; 2.
DR SMART; SM00557; IG_FLMN; 1.
DR SMART; SM00429; IPT; 1.
DR SUPFAM; SSF81296; E set domains; 2.
DR SUPFAM; SSF117281; Kelch motif; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
DR PROSITE; PS50194; FILAMIN_REPEAT; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000006643}.
FT DOMAIN 345..435
FT /note="IPT/TIG"
FT /evidence="ECO:0000259|SMART:SM00429"
FT REPEAT 435..551
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT DOMAIN 1365..1503
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2003..2153
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT REGION 3308..3336
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 2599..2626
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2849..2904
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3170..3232
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 4083 AA; 458318 MW; 1994733AAE856B69 CRC64;
MPIGYGCEPE LVWIAPKQNG EIPVKRSGHS FTLQSSDTET AVYMFGGCDH KSPPGPTNEL
YRLDASNGYT WSKVTSSQSE DEVPAPRWRH SAILYEKNII IFGGFAAEKR MNDLWVFKTE
LKVWEQKYAQ SFWEGLPQCR GAHSATLVGE KMYVFGGYGG NGFGRTDFND LHALDLHSFK
WQEIQTDGEK PEPRSGHQTC LVKEQLLVIG GWNSFKQFQD IFVFDLPTKT WSLLSTPLYS
PIWNHTCVSV AAVPHWKVFL FGGNSGDLAE SGTAQGAYLN STAVLDTGSM VWLNPPVKGE
LPKARADTAM VFDSHTNHLI FFGGWANRWY NDLHVLNASE IVGPPYSISS IEPKQGPITG
SAKVKVTGFN FTGQNATLRF AVAKGSVDVT GAVLSPTVLQ ATAPSYEKFG PLTSEVRVSL
SGGMYTNVAT SFRFHSVTAA PKSLAFGPCL IAALNDNCLA ELPTTFIIQS RDKDDNPRDC
GGDEFAITLK YCDDPQAEVE QVASILDKND GTYVVTFTPS RAGKYEISVD FMGTFSGVAG
PLRGSPFPAV FQPPSDDNKA KSLPPLATQK DFDSPEVIRR VMATMNKRNG EFRRILVDLR
KDIPSNDTDG LETLRKMKEI IRKLEVDKDI NHLVLDQVRQ LFFSIKKSGG HVDKELVEIE
NMEKLFVDVE KQIPVTEKRT QEPTRIFSEK TEEKIIAYEK MIAQKMETLK TLDFWSSKLE
PDKGLEKIES YLVDWNMEMR KCEENTKLCS IFGFPQLMNE SLRMMGLMRA DADAMKTVWA
IIKRAKAFFK ATQDILFKEV DVNALQIEVQ SALKELKKIP KGIQWSDAYT SILKECQAFD
KTHPLIRCVW SSYMRPRHWK RIMAHTGEFP TPDEDPEQRL SLIMSKNLFN FSSDINEICY
EAEKEQELEL RLIELEALWA EVNWEMTPYN PGAAEEEIVP LLKVSEENFE LLETHQIDVQ
GMSASPYQSE FEPRVGKLQI GLSSINEVVL LLGDIQRSWS YLEPLFIQSE EVKKQLPELT
SDFEDIDREV RQILKTAWIT LNVQEACTEP GLIKRLEVIV EKLELCKHRL KEFLDGRRRQ
FPRFYFMSEA DLLDILSNGS HPDRIMPHCS KIYLATKTLT LVDRGPGERP VATSFVAGVG
HEIVDFFEPP VLEGEAEIYL ETIMRAMRLT LFKHIERSLV AYMEMPRVDW INFKDDTNKP
MDAAQIILLA AGVHYVQEVE RAFRGIQGGD KDALINYNKM QEQQLEDLIK LTQSNISYAE
RQRVMVLITM DAHGRDIVAN MIRGGVDEAT HFQWQSQLKH YFSPAAGSFL KRDMTFRGAN
NARAQILICD AGIPYDYEYL GNGPRLVITP LTDRIYVTAT QALNLQMGCA PAGPAGTGKT
ETTKDLANAL GKVCYVFNCS PEMDFKSLGN IFKGLASSGS WGCFDEFNRL VPEVLSVCSV
QFKAVCDACK ADDEEFVLEN DEVMLDPTVG AFITMNPGYL GRSELPEGLK ALFRPMTVMV
PDLVLICENM LMAEGFTQAK ILASKFYGLY SLLGQLLSKQ LHYDWGLRAV KSVLCVAGAF
KRAEPDIPET DLLMRALRDF NIPKIVAEDM VIFFGLLGDL FPRDSPNVDV RNDPPRKRDM
ELESMVQGAS EAIGNTPRPE FMLKVVQLSE LLAIRHCVFV MGPPASGKTE TWKTLRKARE
IMGTPMEVQD LNPKSVSTNE LYGYIVLKTR EWKDGLLSRI MRDLGSRRRD NGDEDNNPKW
IILDGDLDAN WIESMNSVMD DNRMLTLASN ERIPLKVHMR MIFEIRDLVY ATPATVSRAG
ILYISTSEGY QWRCLIDSWL DRHCQPPADH RLRNMMFTPD THAKFQGLFD QYVETTLRFF
RKKLVPVVPV EETTLVTNLL NMIDCLLTPQ VLEDYTVMQN TFVFCCVWSF GSILTMSDDG
TDYSAEFSNW WKNQWKDVKL VASASNTVFD FWLDPETSKF NSWSKSPYFY TETYVSPSPI
NQITVPTTET ASIAFWLENL ISKSVPVMVC GPAGTGKTQN IMGMLKKLSK DEATAAFRYC
TINFNFYTTS AILQQTMFGQ LERKTGINLG PPGKARLIYF MDDLNLPEVD PYNTQSAISL
LRQVMEYKHW FDRVKLQTQN ILNTQVVSGM NPTAGSFLVD PRLQRHFCTF AMGMPEAPSL
VTIYETFLGG HLSGFADELS NSQFSNALIK AALSLHASVV GTFRKTAANF HYEFNVRHLS
NVFQGLIASK KDRFNSQEKF VLLWLHESER VYGDRLVCKA DIEKYNQLVQ MQVKKSFASC
NTSRYYAAEN SWPLIFCHFT KDGDSEYDQI MGTNLDDLKM NLQVQLREYN NNENNTAMQL
DLFDDAVKHV ARIVRILRNE SGHALLVGVG GSGKRSLARL ASHICGCTVR QITISSKYGE
NEFKEDLRKM HMAVVEMLSR NEEDGGVVFM LTDSQITNEK FLIYLNDLLA SGEIPDLFAM
EDMDNIVNLL SPVAGTKDRK EVIKFFQAEI RKRLHLCLCF SPVGDDFRNR ARKFPALVNC
TVIDWFQPWP KEALLSVGRE KLKEIGDLLG SEESRAGIEK FMPLSFQSVN ICAERFLQVE
RRHVYTTPKS YLELLQLYKK ILRKKVEEYA AAIDRLEKGL QKLKETGDTV SRLEVELKVI
LEAAEDKKAV ASGIAEAVNK EKANVETESK KAGDEAAKCA IIQTEVTEKQ RSTQEDLAKA
EPAVAQAMAA LDSLNKKDLG ECKTMSKPPA GVDDVFSATM VLLAGVHPNV QVTKTGKVKD
VKWDTVKKQL LGNIPEYIEY LVGFKQVVDD GKVPPTNWKE VRVFLEMEHF HYDTILTKNK
AAAGLCSWVI NIVMYYDIVI TVEPKRQALA AANLELEAAN ARLTEVTALV ADLQAKLDKL
LAEAAAAEKE KEDAINAVET GNRKMKLAGT LTNDLSSENV RWGINVLQLQ KEKDLLVGDV
LLASAFISYI GPFTKPFRDE LINKHWVPYL RTAAGGESIA MSEEANPLLI LTNDAQIAQW
NTQKLPSDRV STENGAIVVT TVSMGRRPLI VDPQLQAIAW IREMEAHNNL IIVRVGQKMW
IERLKTAIGT DGAFLIENLG EKIDPILAPV IQRSTSRRGA RYEIQIGDAS VPYNDNFHLY
LHTKLGNPHY PPEIQAECTI VNFTVTMLGL EDQLLNLTVS KERQDLAIKR EKLIQEQNNG
KIELKKLEDD ILFYLASADD DITNNQPLIQ ILSDTKHKAQ RTQNNMEAAK KTQESVNITS
EKYRSIAARG SLLFFLMNDI SKVHSYYIYS LASFQQVFLS GIYRAPPAKN LIANEVDGGA
EGDAAAVETP AEGGKNGEGG SDDEAEETEP AVPDLTDEEM KERCQVLMDS ITSCVYNYVR
RGLFERNKLT VATMLCLKIL LKDGLLNDTE VEYFLISKAH PDAGNAGSAS EWLPAAIWAK
LKALESLKAF AGIGDAIQND PDEWRKWFAT EDAERQKIPG DFIKLTAFQR LILLRAMRPD
RVTNALRTFI LDSLGEEYVT QPPFNMEATY AETNSSIPIF FVLFPGVDPT PWVETLGKAN
GVSLENNNFI NISMGQGQEA YAGDALKRLS TEGGWIILQN VHLMQSWLPT LERQLEEVAT
EGAHDLFRCF ISAEPPPLPD MLNIPESLLQ SCIKVANEAP SDIQSNLRRA WANFGEDKVQ
ACTKPAEFKA CLFALCWFHA IVLGRRRFGQ QGWSRAYSFN TGDLTICANI LHSYLDNNAS
VPWDDLRYLF GEIMYGGHIT DAWDRRTNNT YLAVLIDPGL LNGMELGPGF KSPNPQEFSF
ADYANYIEKN MVPEAPPLFG LHPNAEIGYL TTTCETLCYT IVTIGGGAGG GGGGEEGGGD
KTAALRASID DLEARCPEFF NMLDVVEAAT PHLTEDHGPF VVVALQECSR MNVLLQEIRL
SLGDLKKGLN GQLNMSQAME DLATAMSLNE VPGRNPFSQC KWEKKAWPST KSLSGWFADM
VKRYEQLVMW AGDTSGGGGS CFVTPFSIWL PGLFNPTAYT TACLQVTSRK RFMPLNQMTV
ETHVTTIQDP STVSHYPDDG VFVHGLILEG ARWSTLDEIN ERYPVGATPP TECGVCLSST
SRL
//