ID D0N3B9_PHYIT Unreviewed; 1512 AA.
AC D0N3B9;
DT 15-DEC-2009, integrated into UniProtKB/TrEMBL.
DT 15-DEC-2009, sequence version 1.
DT 27-MAR-2024, entry version 80.
DE RecName: Full=1-phosphatidylinositol-3-phosphate 5-kinase {ECO:0000256|ARBA:ARBA00012009};
DE EC=2.7.1.150 {ECO:0000256|ARBA:ARBA00012009};
GN ORFNames=PITG_05644 {ECO:0000313|EMBL:EEY69411.1};
OS Phytophthora infestans (strain T30-4) (Potato late blight agent).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=403677 {ECO:0000313|EMBL:EEY69411.1, ECO:0000313|Proteomes:UP000006643};
RN [1] {ECO:0000313|Proteomes:UP000006643}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=T30-4 {ECO:0000313|Proteomes:UP000006643};
RX PubMed=19741609; DOI=10.1038/nature08358;
RG The Broad Institute Genome Sequencing Platform;
RA Haas B.J., Kamoun S., Zody M.C., Jiang R.H., Handsaker R.E., Cano L.M.,
RA Grabherr M., Kodira C.D., Raffaele S., Torto-Alalibo T., Bozkurt T.O.,
RA Ah-Fong A.M., Alvarado L., Anderson V.L., Armstrong M.R., Avrova A.,
RA Baxter L., Beynon J., Boevink P.C., Bollmann S.R., Bos J.I., Bulone V.,
RA Cai G., Cakir C., Carrington J.C., Chawner M., Conti L., Costanzo S.,
RA Ewan R., Fahlgren N., Fischbach M.A., Fugelstad J., Gilroy E.M., Gnerre S.,
RA Green P.J., Grenville-Briggs L.J., Griffith J., Grunwald N.J., Horn K.,
RA Horner N.R., Hu C.H., Huitema E., Jeong D.H., Jones A.M., Jones J.D.,
RA Jones R.W., Karlsson E.K., Kunjeti S.G., Lamour K., Liu Z., Ma L.,
RA Maclean D., Chibucos M.C., McDonald H., McWalters J., Meijer H.J.,
RA Morgan W., Morris P.F., Munro C.A., O'Neill K., Ospina-Giraldo M.,
RA Pinzon A., Pritchard L., Ramsahoye B., Ren Q., Restrepo S., Roy S.,
RA Sadanandom A., Savidor A., Schornack S., Schwartz D.C., Schumann U.D.,
RA Schwessinger B., Seyer L., Sharpe T., Silvar C., Song J., Studholme D.J.,
RA Sykes S., Thines M., van de Vondervoort P.J., Phuntumart V., Wawra S.,
RA Weide R., Win J., Young C., Zhou S., Fry W., Meyers B.C., van West P.,
RA Ristaino J., Govers F., Birch P.R., Whisson S.C., Judelson H.S.,
RA Nusbaum C.;
RT "Genome sequence and analysis of the Irish potato famine pathogen
RT Phytophthora infestans.";
RL Nature 461:393-398(2009).
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DR EMBL; DS028124; EEY69411.1; -; Genomic_DNA.
DR RefSeq; XP_002999265.1; XM_002999219.1.
DR STRING; 403677.D0N3B9; -.
DR EnsemblProtists; PITG_05644T0; PITG_05644T0; PITG_05644.
DR GeneID; 9475361; -.
DR KEGG; pif:PITG_05644; -.
DR VEuPathDB; FungiDB:PITG_05644; -.
DR eggNOG; KOG0230; Eukaryota.
DR HOGENOM; CLU_000480_1_1_1; -.
DR InParanoid; D0N3B9; -.
DR OMA; SWIPRRT; -.
DR OrthoDB; 5481504at2759; -.
DR Proteomes; UP000006643; Partially assembled WGS sequence.
DR GO; GO:0000285; F:1-phosphatidylinositol-3-phosphate 5-kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0046488; P:phosphatidylinositol metabolic process; IEA:UniProtKB-UniRule.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd15725; FYVE_PIKfyve_Fab1; 1.
DR CDD; cd17300; PIPKc_PIKfyve; 1.
DR Gene3D; 3.30.810.10; 2-Layer Sandwich; 1.
DR Gene3D; 3.50.7.10; GroEL; 1.
DR Gene3D; 3.30.800.10; Phosphatidylinositol Phosphate Kinase II Beta; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR002423; Cpn60/GroEL/TCP-1.
DR InterPro; IPR027409; GroEL-like_apical_dom_sf.
DR InterPro; IPR044769; PIKfyve_PIPKc.
DR InterPro; IPR027483; PInositol-4-P-4/5-kinase_C_sf.
DR InterPro; IPR002498; PInositol-4-P-4/5-kinase_core.
DR InterPro; IPR027484; PInositol-4-P-5-kinase_N.
DR InterPro; IPR000306; Znf_FYVE.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR45748; 1-PHOSPHATIDYLINOSITOL 3-PHOSPHATE 5-KINASE-RELATED; 1.
DR PANTHER; PTHR45748:SF7; 1-PHOSPHATIDYLINOSITOL 3-PHOSPHATE 5-KINASE-RELATED; 1.
DR Pfam; PF00118; Cpn60_TCP1; 1.
DR Pfam; PF01363; FYVE; 1.
DR Pfam; PF01504; PIP5K; 2.
DR SMART; SM00064; FYVE; 1.
DR SMART; SM00330; PIPKc; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR SUPFAM; SSF52029; GroEL apical domain-like; 1.
DR SUPFAM; SSF56104; SAICAR synthase-like; 1.
DR PROSITE; PS51455; PIPK; 1.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|PROSITE-ProRule:PRU00781};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000256|PROSITE-
KW ProRule:PRU00781}; Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU00781};
KW Reference proteome {ECO:0000313|Proteomes:UP000006643};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PROSITE-
KW ProRule:PRU00781}; Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00091}.
FT DOMAIN 17..71
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT DOMAIN 1160..1498
FT /note="PIPK"
FT /evidence="ECO:0000259|PROSITE:PS51455"
FT REGION 78..160
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1044..1082
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 78..114
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 138..160
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1512 AA; 168631 MW; FCDF32C8BA115420 CRC64;
MSAGNQYWMP DHLCKVCYDC SAAFSLFRRR HHCRLCGQIF CYECSSQFVD GTPHSFPGVI
RVCTFCFQFA DAAGKKKLHD KDQRRHSIES LDANETSRES FSSRFDRTSH RLSEELSGVK
PSPLVFGPPV DPNEVPTLLS PVDSNSSDIE QSADPTSATN ESIDLFEESD STEVQRRFRP
QVRTRRRRSS AELLDAIESG GLMEAEVLAF KQGRKKASPK KEVSTVLEET QWELATQNSN
NLHTQREIAL DMYMQSAHEQ IRDGIKQSVS ALSKGLPEAE AIDRDQLALT LEDMAFVVTG
HLLFSMNFRS PSGFNYSNLV KVKSIAMATS SKKEPSYNFK WLAGTVCHKH LSHKQMAREV
ANPRILLFAC GISYDRSNGT GRMSSLDTLL EQEKSYMAIL VDKISALEPD VIFVEKTVSR
HAQELLCERR ISIVLNVKSE MLRRIARHTG ADVLTSVDHV DKADPAKVIG RCRSFMVKSI
PVVPDEGLSP AKKSLQALAG VFMKAPAVPS RLRTDTYLYL DGCDPLNGCT VLITGPSKQT
LRVFKQLTRT VLSMTYQLLL EAHVLSDLDL NKNIRAKLSE EQHTTWCTTS TLRVRDPGSS
NPRYHQCVEA KHLRITACSD EDVSFGNFLN QELAALSLKC QNVKCNRLMA EHVHSFSCRT
GTITISFEEL PDKNKQSLSM SLSQASDPGV TDKSFGSFSE LSFTMGSERD INLLAMMTPN
SFSQPSGSED DTALAAENGY PTVIFWRWCH ECKGVISPFI PLEKYIYKYS FARFLEVLFT
EAEGSVLPKS PSAMCAHTSM ESHVLFFNIG NSVARFEFQK QVSLRLDRSN LKHGTGIVHL
KQPLEKTERE IVEKEVSARL EGLKGLLKAL IQSFTEKVQG IIQAVEAFER TDTDHHHARI
ILEVMCISKM VRSGDAMISH KLTQLEQETA NSLGACDATH RALYLMACKW ITCILRLRKL
VKKHVSTETA PPAPNSGSFT LGGVTFHPSA VMSPIVSPRV VEEATLTPSV IIKEPDWGEG
AEPLVRRRSS GALNSAIESE VMTRSAVSPS STIGHIESLK RPPMPFSSGA SSSGDGKESS
RPGWKDALLD LYRVLGRPEP GSDFTIDLPE ELTTGHPSLP HRSKSRVVLV NEAQPITWVA
YALSTDSYEE ELDGWKLRVH SEGVESVDAQ KQHFDGASTN WSRAALETTL NVPFKFAAIE
MPLHLSLLSG KTSSTMSNTC WELSTIAYYP LQFEVLRELF YGSLQNFAFS ISHVANWDAN
GGKSGASFYR TLDDRFVIKH ISSKEMQSFL GCLPEYFKYM ASIYFDGCAS LLSKTVGLYQ
TTITRKDSGQ KTVQYICVME NAFYQKQLTR TYDLKGSSRN RFAKPRPSSE NDTSGRVLLD
GNFLEFTKGH PVGVLAEDHK FILKAVENDT AFLYSINIVD YSMVMGLSYR RDTVKGEDDE
DPSEMTVGII DYLRQFDLIK RVESVGKSVG MIAGQSSPTI IEPGLYGKRF RDAIHRYFMP
VTPISSGTND DK
//
