ID D0N8N6_PHYIT Unreviewed; 1972 AA.
AC D0N8N6;
DT 15-DEC-2009, integrated into UniProtKB/TrEMBL.
DT 15-DEC-2009, sequence version 1.
DT 27-MAR-2024, entry version 73.
DE SubName: Full=Brefeldin A-inhibited guanine nucleotide-exchange protein, putative {ECO:0000313|EMBL:EEY53921.1};
GN ORFNames=PITG_07567 {ECO:0000313|EMBL:EEY53921.1};
OS Phytophthora infestans (strain T30-4) (Potato late blight agent).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=403677 {ECO:0000313|EMBL:EEY53921.1, ECO:0000313|Proteomes:UP000006643};
RN [1] {ECO:0000313|Proteomes:UP000006643}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=T30-4 {ECO:0000313|Proteomes:UP000006643};
RX PubMed=19741609; DOI=10.1038/nature08358;
RG The Broad Institute Genome Sequencing Platform;
RA Haas B.J., Kamoun S., Zody M.C., Jiang R.H., Handsaker R.E., Cano L.M.,
RA Grabherr M., Kodira C.D., Raffaele S., Torto-Alalibo T., Bozkurt T.O.,
RA Ah-Fong A.M., Alvarado L., Anderson V.L., Armstrong M.R., Avrova A.,
RA Baxter L., Beynon J., Boevink P.C., Bollmann S.R., Bos J.I., Bulone V.,
RA Cai G., Cakir C., Carrington J.C., Chawner M., Conti L., Costanzo S.,
RA Ewan R., Fahlgren N., Fischbach M.A., Fugelstad J., Gilroy E.M., Gnerre S.,
RA Green P.J., Grenville-Briggs L.J., Griffith J., Grunwald N.J., Horn K.,
RA Horner N.R., Hu C.H., Huitema E., Jeong D.H., Jones A.M., Jones J.D.,
RA Jones R.W., Karlsson E.K., Kunjeti S.G., Lamour K., Liu Z., Ma L.,
RA Maclean D., Chibucos M.C., McDonald H., McWalters J., Meijer H.J.,
RA Morgan W., Morris P.F., Munro C.A., O'Neill K., Ospina-Giraldo M.,
RA Pinzon A., Pritchard L., Ramsahoye B., Ren Q., Restrepo S., Roy S.,
RA Sadanandom A., Savidor A., Schornack S., Schwartz D.C., Schumann U.D.,
RA Schwessinger B., Seyer L., Sharpe T., Silvar C., Song J., Studholme D.J.,
RA Sykes S., Thines M., van de Vondervoort P.J., Phuntumart V., Wawra S.,
RA Weide R., Win J., Young C., Zhou S., Fry W., Meyers B.C., van West P.,
RA Ristaino J., Govers F., Birch P.R., Whisson S.C., Judelson H.S.,
RA Nusbaum C.;
RT "Genome sequence and analysis of the Irish potato famine pathogen
RT Phytophthora infestans.";
RL Nature 461:393-398(2009).
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DR EMBL; DS028128; EEY53921.1; -; Genomic_DNA.
DR RefSeq; XP_002904552.1; XM_002904506.1.
DR STRING; 403677.D0N8N6; -.
DR EnsemblProtists; PITG_07567T0; PITG_07567T0; PITG_07567.
DR GeneID; 9462637; -.
DR KEGG; pif:PITG_07567; -.
DR VEuPathDB; FungiDB:PITG_07567; -.
DR eggNOG; KOG0929; Eukaryota.
DR HOGENOM; CLU_000691_1_0_1; -.
DR InParanoid; D0N8N6; -.
DR OMA; MENQVYE; -.
DR OrthoDB; 204547at2759; -.
DR Proteomes; UP000006643; Partially assembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR CDD; cd00171; Sec7; 1.
DR Gene3D; 1.10.220.20; -; 1.
DR Gene3D; 1.10.1000.11; Arf Nucleotide-binding Site Opener,domain 2; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR032629; DCB_dom.
DR InterPro; IPR015403; Mon2/Sec7/BIG1-like_HDS.
DR InterPro; IPR032691; Mon2/Sec7/BIG1-like_HUS.
DR InterPro; IPR046455; Sec7/BIG1-like_C.
DR InterPro; IPR023394; Sec7_C_sf.
DR InterPro; IPR000904; Sec7_dom.
DR InterPro; IPR035999; Sec7_dom_sf.
DR PANTHER; PTHR10663; GUANYL-NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR10663:SF375; LD29171P; 1.
DR Pfam; PF20252; BIG2_C; 1.
DR Pfam; PF16213; DCB; 1.
DR Pfam; PF01369; Sec7; 1.
DR Pfam; PF09324; Sec7-like_HDS; 1.
DR Pfam; PF12783; Sec7-like_HUS; 1.
DR SMART; SM00222; Sec7; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF48425; Sec7 domain; 1.
DR PROSITE; PS50190; SEC7; 1.
PE 4: Predicted;
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000006643};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 618..814
FT /note="SEC7"
FT /evidence="ECO:0000259|PROSITE:PS50190"
FT REGION 115..150
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 240..272
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 574..601
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 822..843
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 873..919
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1056..1138
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1395..1417
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1439..1460
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1665..1686
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 117..138
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 579..594
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 892..919
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1062..1121
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1671..1686
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1972 AA; 215400 MW; 610449F3893FE49B CRC64;
MEALVLKSLG KLRKACTRSH RELRDMVDAA QAKVTAASQE GTLEVPFEPF LLACLTRHAK
LVAVALDCME KFLAFGFLKE AGTIPDGIRR RLVQKAAAAS STSGRRSGFG LGLGSGSGAG
SGQSGSNATP SFGLATPSNS HRDAGAEEDS NEDSYRLIDC IVEVACDCND HPDEGVQIQV
LRVLLTAVTT PTCEVHEHAL LRAVRACYHV HLQIISIVFQ RMETFDRRVE EETKATLQAL
DKQEQQSQQE DESEAQEVQA QEQHVVSDSD SDDDILLKTL RAQPTSAWYP SVAVALRLPR
PAHSEKAPVS STTAKKIKAV ATLSQPVNAP AFPSVLHKDA FLLFRSLCRI SMRSVADDSG
NGSTAGSAGN GANPEDPFAF QSKILSLELV KEIVENAGPS FRRGERFVHA IRQYLCQSLL
QNCTSNYTQI VSLSLQVFLV LLRNFKRHLK TELDIFITSI FLRLLQSENA SFEHKLLVLE
ALHAICDDPQ TLGEIFINYD CDWNTNDLFK QIVHALAKAA KGGRSQDAAA QQYAASLSSS
ARIKMQHQDA ALALKGLECL TATTASLKKA ANFVETERQS SQHEGEETHN SEIGGEEDTV
APPDLVPVVS STMSAVEAFE SKKKRQEEMA TGILKFNVKP SAGIAYLVAH GHMGEGSPRD
VAQFLHSYND KLDKTMVGDY LGNGVHYQGG FCVKVLHEYV DMMDFTGLEI DVAIRHFLAG
FRLPGESQKI DRMMEKFAER FFNACPPGLF PSADTAFILA FSIIMLQTDL HNPSIAEEKK
MDKSGFLRNN RGINDGKDLP EDYMGAIFDR IKATPISLKE DDDFRSRRGG AAPSATSSLF
GASNAATDRM RRDAYIKERE SMVRQSEALF KRRVPASARA QQHFPLSPRG DKPSATSGSG
SGASPSQRSE GPSSLLTPDP LASTFHEVSG YNERSHVRPM FETLWAPLLA ACSVTFESSE
SVEAIQLCLD SFRHAVHLSA RLSMPAERDA FVTVLAKFTA LHTTNSRLMR SKNMEAIKAL
ISISVKEGNH LGDSWHDVLQ AISQLARIQT HAQGLHERSA AGSVSGDSSY FNRQPSPGMS
HSSSRNSSAN STPSFSMLGS ASGSKRSGLG SSLSSPSPSH RDIGGRGSGS ELDEAQSAAI
EDENAARVLS EIDQLASDRV FSSSVSLSDQ ALQDFVVQLT VVSLSECSGV GPSGAAGGSP
PRVFSLQKLV EVADMNMRTR SRMVWAATWQ TLSRHFTTIG CHEDLTVGIM KFLERAELRD
FNFQRLFLAP FEVIMANATS LETRELVLRC VENLVLARVG NIRSGWKTIW GVLRIAAETY
APGSEDRVVL LGFQVAHGVL ERHFDCIVDV FVDAVECLLA FSVCGSPASA AAAAAAKQAA
RVGFKKVKVL TEEDPTADAS SDGVHSPSKR ASIRYQKQES VRSLEEEVAE LSPRKVVASP
LSPRRRSSSV EMQDKEQLET GEAAYNDSAA HTRMWWPVLT ALSTLAADRR LDVRLAALEA
LFSALETHGT KFTSGLWGLV FKGVLIPLLD ELRHLEVVVE KGACARPKLP LPLSASSSRM
PQYTAGKTTA TLCLERLLEC FGLFYDIVGF LPEVLFLLGK CMDAGDAEEQ LAAASARALE
VVLVTHGHKF PEDVWGLISD ELRNVMKRAE PTWIFFALPP EDDDDAPIGD SASQSPRSPM
ASPVAANLTS PRQPSLLSLY PGVVGTLGFA FTTSFPPKMI TTDEVEAQRV PSRTHLTVLL
ALQRVAGNVL ASRRKENLSL SVGHARSLLS CLRESFLFAR KVNDAVSLRR YLQRVGWRYG
MTVPSSSELP SLLPQEVLGK QQYLHVLFTA LVRSVNNAQV APIGEQDEAR KYMVRLVQDT
LEEYLAWTGV APQYIDQDKM PADAQQRVES YTPLLVATLR ELAEFDSTEL QRHMSWLYPL
LTDLVMVANT EVRVALSCVF SRAQTFATAL ATADSEDQVK ARSRKAIRAA SL
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