ID D0NMI3_PHYIT Unreviewed; 621 AA.
AC D0NMI3;
DT 15-DEC-2009, integrated into UniProtKB/TrEMBL.
DT 15-DEC-2009, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=sphingosine kinase {ECO:0000256|ARBA:ARBA00044037};
DE EC=2.7.1.91 {ECO:0000256|ARBA:ARBA00044037};
GN ORFNames=PITG_13666 {ECO:0000313|EMBL:EEY60904.1};
OS Phytophthora infestans (strain T30-4) (Potato late blight agent).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=403677 {ECO:0000313|EMBL:EEY60904.1, ECO:0000313|Proteomes:UP000006643};
RN [1] {ECO:0000313|Proteomes:UP000006643}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=T30-4 {ECO:0000313|Proteomes:UP000006643};
RX PubMed=19741609; DOI=10.1038/nature08358;
RG The Broad Institute Genome Sequencing Platform;
RA Haas B.J., Kamoun S., Zody M.C., Jiang R.H., Handsaker R.E., Cano L.M.,
RA Grabherr M., Kodira C.D., Raffaele S., Torto-Alalibo T., Bozkurt T.O.,
RA Ah-Fong A.M., Alvarado L., Anderson V.L., Armstrong M.R., Avrova A.,
RA Baxter L., Beynon J., Boevink P.C., Bollmann S.R., Bos J.I., Bulone V.,
RA Cai G., Cakir C., Carrington J.C., Chawner M., Conti L., Costanzo S.,
RA Ewan R., Fahlgren N., Fischbach M.A., Fugelstad J., Gilroy E.M., Gnerre S.,
RA Green P.J., Grenville-Briggs L.J., Griffith J., Grunwald N.J., Horn K.,
RA Horner N.R., Hu C.H., Huitema E., Jeong D.H., Jones A.M., Jones J.D.,
RA Jones R.W., Karlsson E.K., Kunjeti S.G., Lamour K., Liu Z., Ma L.,
RA Maclean D., Chibucos M.C., McDonald H., McWalters J., Meijer H.J.,
RA Morgan W., Morris P.F., Munro C.A., O'Neill K., Ospina-Giraldo M.,
RA Pinzon A., Pritchard L., Ramsahoye B., Ren Q., Restrepo S., Roy S.,
RA Sadanandom A., Savidor A., Schornack S., Schwartz D.C., Schumann U.D.,
RA Schwessinger B., Seyer L., Sharpe T., Silvar C., Song J., Studholme D.J.,
RA Sykes S., Thines M., van de Vondervoort P.J., Phuntumart V., Wawra S.,
RA Weide R., Win J., Young C., Zhou S., Fry W., Meyers B.C., van West P.,
RA Ristaino J., Govers F., Birch P.R., Whisson S.C., Judelson H.S.,
RA Nusbaum C.;
RT "Genome sequence and analysis of the Irish potato famine pathogen
RT Phytophthora infestans.";
RL Nature 461:393-398(2009).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a sphingoid base + ATP = a sphingoid 1-phosphate + ADP + H(+);
CC Xref=Rhea:RHEA:51496, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:76941, ChEBI:CHEBI:84410, ChEBI:CHEBI:456216;
CC EC=2.7.1.91; Evidence={ECO:0000256|ARBA:ARBA00043822};
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DR EMBL; DS028146; EEY60904.1; -; Genomic_DNA.
DR RefSeq; XP_002899850.1; XM_002899804.1.
DR AlphaFoldDB; D0NMI3; -.
DR STRING; 403677.D0NMI3; -.
DR EnsemblProtists; PITG_13666T0; PITG_13666T0; PITG_13666.
DR GeneID; 9462289; -.
DR KEGG; pif:PITG_13666; -.
DR VEuPathDB; FungiDB:PITG_13666; -.
DR eggNOG; KOG1116; Eukaryota.
DR HOGENOM; CLU_013826_1_0_1; -.
DR InParanoid; D0NMI3; -.
DR OMA; FRVHFFR; -.
DR OrthoDB; 7645at2759; -.
DR Proteomes; UP000006643; Partially assembled WGS sequence.
DR GO; GO:0016301; F:kinase activity; IEA:InterPro.
DR Gene3D; 2.60.200.40; -; 1.
DR InterPro; IPR017438; ATP-NAD_kinase_N.
DR InterPro; IPR001206; Diacylglycerol_kinase_cat_dom.
DR InterPro; IPR016064; NAD/diacylglycerol_kinase_sf.
DR PANTHER; PTHR12358:SF31; LD11247P-RELATED; 1.
DR PANTHER; PTHR12358; SPHINGOSINE KINASE; 1.
DR Pfam; PF00781; DAGK_cat; 1.
DR SUPFAM; SSF111331; NAD kinase/diacylglycerol kinase-like; 1.
DR PROSITE; PS50146; DAGK; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000006643}.
FT DOMAIN 309..450
FT /note="DAGKc"
FT /evidence="ECO:0000259|PROSITE:PS50146"
FT REGION 1..91
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 119..139
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..37
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 45..69
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 621 AA; 68708 MW; EC8A6DA7691464C9 CRC64;
MSPTTSRGPD GALSVTPRRS NASFLDGLNT PPSSHGKSSV HFADEEASYA SQSSNLLSPR
GVRSSDVELT TPKTPEEEEE TGSQNGFSLP TLTQAQSNSN AHKNYQQYAQ HQLQLPQLSP
HTRSTGKASS LGMPPKRSRT YVQQLSKESA RELAKTAFSM RSTSVGDFTF ENPHEVVGSS
LRESIRRVTA FSRREAPLDT ELNTVVRVNH YVRKCELRLD PETITWSRGK KTLGVLPTDD
VVGAEVLAKK KADTFRVHYF KKGRGTGAKA LRRTPKFVDF HCLETDVVDS WVGAIQELVR
WQARAPPISE KRLLKVVVNP HSGKRQARRI WQDEVKPYLD LGNFNCVVEE TTHSGHGTEM
GKSYSPDDGF EALVFIGGDG TLCEFMNGLL TRPEHEWREI VASTPISLIS AGTQNAFGTG
AGIPTVNAAL YCILKRKMRP LDVVTAVSAA YPEVVHYSYC GLGWGVAGDI AAESERYRWM
GTLRYAFLKV KRTVVLPKKH SGRVRYVLTE PQPPLLRYDD YPDAAYDMDR FSQQRKSWGG
IAGSISSPAS RKRYPEFLWK EDCSNYVVVG VVNITPDGAY SHPSDGNLDL ILTRKGGLLA
VAKLFGLSKP WRSNPTNPTT A
//
