ID D0NW49_PHYIT Unreviewed; 806 AA.
AC D0NW49;
DT 15-DEC-2009, integrated into UniProtKB/TrEMBL.
DT 15-DEC-2009, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=sphingomyelin phosphodiesterase {ECO:0000256|ARBA:ARBA00012369};
DE EC=3.1.4.12 {ECO:0000256|ARBA:ARBA00012369};
GN ORFNames=PITG_17812 {ECO:0000313|EMBL:EEY66934.1};
OS Phytophthora infestans (strain T30-4) (Potato late blight agent).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=403677 {ECO:0000313|EMBL:EEY66934.1, ECO:0000313|Proteomes:UP000006643};
RN [1] {ECO:0000313|Proteomes:UP000006643}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=T30-4 {ECO:0000313|Proteomes:UP000006643};
RX PubMed=19741609; DOI=10.1038/nature08358;
RG The Broad Institute Genome Sequencing Platform;
RA Haas B.J., Kamoun S., Zody M.C., Jiang R.H., Handsaker R.E., Cano L.M.,
RA Grabherr M., Kodira C.D., Raffaele S., Torto-Alalibo T., Bozkurt T.O.,
RA Ah-Fong A.M., Alvarado L., Anderson V.L., Armstrong M.R., Avrova A.,
RA Baxter L., Beynon J., Boevink P.C., Bollmann S.R., Bos J.I., Bulone V.,
RA Cai G., Cakir C., Carrington J.C., Chawner M., Conti L., Costanzo S.,
RA Ewan R., Fahlgren N., Fischbach M.A., Fugelstad J., Gilroy E.M., Gnerre S.,
RA Green P.J., Grenville-Briggs L.J., Griffith J., Grunwald N.J., Horn K.,
RA Horner N.R., Hu C.H., Huitema E., Jeong D.H., Jones A.M., Jones J.D.,
RA Jones R.W., Karlsson E.K., Kunjeti S.G., Lamour K., Liu Z., Ma L.,
RA Maclean D., Chibucos M.C., McDonald H., McWalters J., Meijer H.J.,
RA Morgan W., Morris P.F., Munro C.A., O'Neill K., Ospina-Giraldo M.,
RA Pinzon A., Pritchard L., Ramsahoye B., Ren Q., Restrepo S., Roy S.,
RA Sadanandom A., Savidor A., Schornack S., Schwartz D.C., Schumann U.D.,
RA Schwessinger B., Seyer L., Sharpe T., Silvar C., Song J., Studholme D.J.,
RA Sykes S., Thines M., van de Vondervoort P.J., Phuntumart V., Wawra S.,
RA Weide R., Win J., Young C., Zhou S., Fry W., Meyers B.C., van West P.,
RA Ristaino J., Govers F., Birch P.R., Whisson S.C., Judelson H.S.,
RA Nusbaum C.;
RT "Genome sequence and analysis of the Irish potato famine pathogen
RT Phytophthora infestans.";
RL Nature 461:393-398(2009).
CC -!- SIMILARITY: Belongs to the neutral sphingomyelinase family.
CC {ECO:0000256|ARBA:ARBA00006335}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; DS028173; EEY66934.1; -; Genomic_DNA.
DR RefSeq; XP_002896652.1; XM_002896606.1.
DR AlphaFoldDB; D0NW49; -.
DR EnsemblProtists; PITG_17812T0; PITG_17812T0; PITG_17812.
DR GeneID; 9471343; -.
DR KEGG; pif:PITG_17812; -.
DR VEuPathDB; FungiDB:PITG_17812; -.
DR eggNOG; ENOG502RV48; Eukaryota.
DR HOGENOM; CLU_360010_0_0_1; -.
DR InParanoid; D0NW49; -.
DR OMA; FAMSKYP; -.
DR OrthoDB; 55899at2759; -.
DR Proteomes; UP000006643; Partially assembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0004767; F:sphingomyelin phosphodiesterase activity; IEA:UniProtKB-EC.
DR CDD; cd09078; nSMase; 1.
DR CDD; cd06093; PX_domain; 1.
DR Gene3D; 3.60.10.10; Endonuclease/exonuclease/phosphatase; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR InterPro; IPR005135; Endo/exonuclease/phosphatase.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR038772; Sph/SMPD2-like.
DR InterPro; IPR017766; Sphingomyelinase/PLipase_C.
DR PANTHER; PTHR16320:SF23; SPHINGOMYELINASE DDB_G0288017; 1.
DR PANTHER; PTHR16320; SPHINGOMYELINASE FAMILY MEMBER; 1.
DR Pfam; PF03372; Exo_endo_phos; 1.
DR Pfam; PF00787; PX; 1.
DR SUPFAM; SSF56219; DNase I-like; 1.
DR SUPFAM; SSF64268; PX domain; 1.
DR PROSITE; PS50195; PX; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000006643}.
FT DOMAIN 74..198
FT /note="PX"
FT /evidence="ECO:0000259|PROSITE:PS50195"
FT REGION 213..236
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 216..236
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 806 AA; 87384 MW; 9F99AE52D0AE7A3D CRC64;
MVIQILSRFA STAVTGTNNP TLTMLVGTSS LLPRTRRLLA SASHFDMMSW RRKPLVLAHQ
SAVEAPSSPA PWLATDADVG ITRVSASAAK SEHCSYEISL RFPQTRTLWL IQRSYTDFQR
FHAAIESIFH QVLHARRIQL PKPSRLGWDA FRAQSARTAA ADKLRKQLNS YLHKLLEIES
VHASDAFRDF VTPRPESDDS EVVQEDCADK VEGSSSFRRL GSSSTSTTST STTVSSRDSV
DGLLLDMPAP FPWRVPPPVV APSTCDELVH FGGTIALTAL GGLSVGLTKR SALSGSQKAA
AVAAGVAGVA LTGPLSAVFA LSALGGGVGK YQLNKASYLS VCKPSHGDDD TGIAFVVENA
EQFSGPRRAA RFGDAIHLYC RKVRRSVRII AAPDSKRGHA MVSGGDAHKT TLRLVSPYGH
TGPLRCGSQV FMQLVDGEWA GQLLGMHGEF ITATKYSPTV FQLGTISSEH VAVDCPETAT
KTEQQERLSG PFTVPRSAIP FKLRVMVYNV WLLPGFVSSF NEKVSPWASQ RASAIPRCLA
SLNVDVVVFC EAFCSSAREK LVSGMKSQGF IYETKIVGDV SLLSSKKAID GGCFAMSKYP
LSNCEEVTFG NVASGEDRYA DKGVIYFQVR VPVKSYSGSD TTQTVHIVGT HLQAWETSLA
VATRKGQMTL MRNFVNSLRL PKHEPVIYAG DMNVNKHADG AQIPEGEYTG MLDLLGVDEP
QLQEKSPIYS FDPHSNDLAV DGPSSGGIAE RLDYVMVDRS HRLPVSASTE IVQLKATKNW
APSRGAIDEI LVDLSDHYPV VGDFHF
//
