ID   D0VXF2_9CAUD            Unreviewed;       168 AA.
AC   D0VXF2;
DT   19-JAN-2010, integrated into UniProtKB/TrEMBL.
DT   19-JAN-2010, sequence version 1.
DT   27-MAR-2024, entry version 47.
DE   RecName: Full=dihydrofolate reductase {ECO:0000256|ARBA:ARBA00012856};
DE            EC=1.5.1.3 {ECO:0000256|ARBA:ARBA00012856};
GN   Name=dfrP {ECO:0000313|EMBL:BAI49173.1};
GN   Synonyms=orf168 {ECO:0000313|EMBL:BAN59528.1};
OS   Bacillus phage phiNIT1.
OC   Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes;
OC   Herelleviridae; Bastillevirinae; Nitunavirus; Nitunavirus NIT1.
OX   NCBI_TaxID=207656 {ECO:0000313|EMBL:BAI49173.1};
RN   [1] {ECO:0000313|EMBL:BAI49173.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Kimura K.;
RT   "Bacillus subtilis bacteriophage NIT1 partial genome sequence.";
RL   Submitted (NOV-2008) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:BAN59528.1, ECO:0000313|Proteomes:UP000014701}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PhiNIT1 {ECO:0000313|EMBL:BAN59528.1};
RA   Ozaki T., Kaneko J.;
RT   "phiNIT1 genome sequensing.";
RL   Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; AB469692; BAI49173.1; -; Genomic_DNA.
DR   EMBL; AP013029; BAN59528.1; -; Genomic_DNA.
DR   RefSeq; YP_008318296.1; NC_021856.1.
DR   GeneID; 16511513; -.
DR   KEGG; vg:16511513; -.
DR   OrthoDB; 9577at10239; -.
DR   Proteomes; UP000014701; Genome.
DR   GO; GO:0004146; F:dihydrofolate reductase activity; IEA:UniProtKB-EC.
DR   GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR   GO; GO:0006545; P:glycine biosynthetic process; IEA:InterPro.
DR   GO; GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0046654; P:tetrahydrofolate biosynthetic process; IEA:InterPro.
DR   CDD; cd00209; DHFR; 1.
DR   Gene3D; 3.40.430.10; Dihydrofolate Reductase, subunit A; 1.
DR   InterPro; IPR012259; DHFR.
DR   InterPro; IPR024072; DHFR-like_dom_sf.
DR   InterPro; IPR001796; DHFR_dom.
DR   PANTHER; PTHR48069; DIHYDROFOLATE REDUCTASE; 1.
DR   PANTHER; PTHR48069:SF3; DIHYDROFOLATE REDUCTASE; 1.
DR   Pfam; PF00186; DHFR_1; 1.
DR   PIRSF; PIRSF000194; DHFR; 1.
DR   PRINTS; PR00070; DHFR.
DR   SUPFAM; SSF53597; Dihydrofolate reductase-like; 1.
DR   PROSITE; PS51330; DHFR_2; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000014701}.
FT   DOMAIN          2..160
FT                   /note="DHFR"
FT                   /evidence="ECO:0000259|PROSITE:PS51330"
SQ   SEQUENCE   168 AA;  19948 MW;  D8E56EF33F625BEA CRC64;
     MHVALIAAMG LNLEIGADNR LLWDIKEDMN WFRQKTKNKV VVMGRKTYES IGKPLKGRVN
     VVLTHNKEYD PHPDVLVRHN LEDIFFEFRN ELEIMVIGGE TIYNQFFPYA NRIYLTQVEK
     TYEEADAFFP EFDCSIWNRY FYQDGSEDIG IKYNFSVYKK RLKLEGED
//