ID D1A5P0_THECD Unreviewed; 550 AA.
AC D1A5P0;
DT 19-JAN-2010, integrated into UniProtKB/TrEMBL.
DT 19-JAN-2010, sequence version 1.
DT 27-MAR-2024, entry version 77.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN OrderedLocusNames=Tcur_0810 {ECO:0000313|EMBL:ACY96400.1};
OS Thermomonospora curvata (strain ATCC 19995 / DSM 43183 / JCM 3096 / KCTC
OS 9072 / NBRC 15933 / NCIMB 10081 / Henssen B9).
OC Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC Thermomonosporaceae; Thermomonospora.
OX NCBI_TaxID=471852 {ECO:0000313|EMBL:ACY96400.1, ECO:0000313|Proteomes:UP000001918};
RN [1] {ECO:0000313|EMBL:ACY96400.1, ECO:0000313|Proteomes:UP000001918}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 19995 / DSM 43183 / JCM 3096 / KCTC 9072 / NBRC 15933 /
RC NCIMB 10081 / Henssen B9 {ECO:0000313|Proteomes:UP000001918};
RX PubMed=21475583; DOI=10.4056/sigs.1453580;
RA Chertkov O., Sikorski J., Nolan M., Lapidus A., Lucas S., Del Rio T.G.,
RA Tice H., Cheng J.F., Goodwin L., Pitluck S., Liolios K., Ivanova N.,
RA Mavromatis K., Mikhailova N., Ovchinnikova G., Pati A., Chen A.,
RA Palaniappan K., Djao O.D., Land M., Hauser L., Chang Y.J., Jeffries C.D.,
RA Brettin T., Han C., Detter J.C., Rohde M., Goker M., Woyke T., Bristow J.,
RA Eisen J.A., Markowitz V., Hugenholtz P., Klenk H.P., Kyrpides N.C.;
RT "Complete genome sequence of Thermomonospora curvata type strain (B9).";
RL Stand. Genomic Sci. 1:13-22(2011).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665};
CC -!- SIMILARITY: Belongs to the helicase family. RAD25/XPB subfamily.
CC {ECO:0000256|ARBA:ARBA00006637}.
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DR EMBL; CP001738; ACY96400.1; -; Genomic_DNA.
DR RefSeq; WP_012851184.1; NC_013510.1.
DR AlphaFoldDB; D1A5P0; -.
DR STRING; 471852.Tcur_0810; -.
DR KEGG; tcu:Tcur_0810; -.
DR eggNOG; COG1061; Bacteria.
DR HOGENOM; CLU_008213_4_0_11; -.
DR OrthoDB; 3713880at2; -.
DR Proteomes; UP000001918; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR CDD; cd18789; SF2_C_XPB; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR032438; ERCC3_RAD25_C.
DR InterPro; IPR006935; Helicase/UvrB_N.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR032830; XPB/Ssl2_N.
DR PANTHER; PTHR11274:SF0; GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPB; 1.
DR PANTHER; PTHR11274; RAD25/XP-B DNA REPAIR HELICASE; 1.
DR Pfam; PF16203; ERCC3_RAD25_C; 1.
DR Pfam; PF13625; Helicase_C_3; 1.
DR Pfam; PF04851; ResIII; 1.
DR PRINTS; PR00851; XRODRMPGMNTB.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000313|EMBL:ACY96400.1};
KW Helicase {ECO:0000313|EMBL:ACY96400.1};
KW Hydrolase {ECO:0000313|EMBL:ACY96400.1};
KW Nucleotide-binding {ECO:0000313|EMBL:ACY96400.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001918}.
FT DOMAIN 190..344
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 395..550
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 550 AA; 61394 MW; F60163B3ACDC1CC1 CRC64;
MTDGPLIVQS DKTLLLEVGH EQADDCRRDI APFAELERAP EHVHTYRITP LALWNARAAG
HDAEQVVDML LRYSRYPVPH ALLVDVADTM SRYGRLRLEK DPAHGLVLTS TDRSVLEEVL
RSKKVKPMLG ARIDEDTVIV HPSQRGHLKQ ALLKLGWPAE DLAGYVDGEA HPVTLVEDGW
ALRPYQREAA DAFWHGGSGV VVLPCGAGKT IVGAAAMARA RATTLILVTN TVSAHQWKQE
LLRRTSLTED EIGEYSGARK EIRPVTIATY QIMTTRRKGA YPHLELLDAR DWGLVIYDEV
HLLPAPIFRM TAELQARRRL GLTATLVRED GREDDVFSLI GPKRYDAPWK EMEAQGWIAP
ADCVEVRVTL TESERLAYAT AEPEDRYRLC ATAHTKTRVI ESLVARHRGE QILVIGQYID
QLDELSALLD APVVKGDTRI RERERLFASF RSGELPVLVV SKVANFSIDL PEASVAIQVS
GAYGSRQEEA QRLGRVLRPK SSGKGARFYA VVARDTLDQE YAAHRQRFLA EQGYAYRIVD
AEAVLAGEDI
//
