ID D1A689_THECD Unreviewed; 337 AA.
AC D1A689;
DT 19-JAN-2010, integrated into UniProtKB/TrEMBL.
DT 19-JAN-2010, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=CNNM transmembrane domain-containing protein {ECO:0008006|Google:ProtNLM};
GN OrderedLocusNames=Tcur_4666 {ECO:0000313|EMBL:ACZ00188.1};
OS Thermomonospora curvata (strain ATCC 19995 / DSM 43183 / JCM 3096 / KCTC
OS 9072 / NBRC 15933 / NCIMB 10081 / Henssen B9).
OC Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC Thermomonosporaceae; Thermomonospora.
OX NCBI_TaxID=471852 {ECO:0000313|EMBL:ACZ00188.1, ECO:0000313|Proteomes:UP000001918};
RN [1] {ECO:0000313|EMBL:ACZ00188.1, ECO:0000313|Proteomes:UP000001918}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 19995 / DSM 43183 / JCM 3096 / KCTC 9072 / NBRC 15933 /
RC NCIMB 10081 / Henssen B9 {ECO:0000313|Proteomes:UP000001918};
RX PubMed=21475583; DOI=10.4056/sigs.1453580;
RA Chertkov O., Sikorski J., Nolan M., Lapidus A., Lucas S., Del Rio T.G.,
RA Tice H., Cheng J.F., Goodwin L., Pitluck S., Liolios K., Ivanova N.,
RA Mavromatis K., Mikhailova N., Ovchinnikova G., Pati A., Chen A.,
RA Palaniappan K., Djao O.D., Land M., Hauser L., Chang Y.J., Jeffries C.D.,
RA Brettin T., Han C., Detter J.C., Rohde M., Goker M., Woyke T., Bristow J.,
RA Eisen J.A., Markowitz V., Hugenholtz P., Klenk H.P., Kyrpides N.C.;
RT "Complete genome sequence of Thermomonospora curvata type strain (B9).";
RL Stand. Genomic Sci. 1:13-22(2011).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
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DR EMBL; CP001738; ACZ00188.1; -; Genomic_DNA.
DR RefSeq; WP_012854969.1; NC_013510.1.
DR AlphaFoldDB; D1A689; -.
DR STRING; 471852.Tcur_4666; -.
DR KEGG; tcu:Tcur_4666; -.
DR eggNOG; COG1253; Bacteria.
DR HOGENOM; CLU_015237_4_0_11; -.
DR OrthoDB; 110231at2; -.
DR Proteomes; UP000001918; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR Gene3D; 3.10.580.10; CBS-domain; 1.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR002550; CNNM.
DR PANTHER; PTHR43099:SF4; INTEGRAL MEMBRANE PROTEIN-RELATED; 1.
DR PANTHER; PTHR43099; UPF0053 PROTEIN YRKA; 1.
DR Pfam; PF00571; CBS; 1.
DR Pfam; PF01595; CNNM; 1.
DR SUPFAM; SSF54631; CBS-domain pair; 1.
DR PROSITE; PS51371; CBS; 1.
DR PROSITE; PS51846; CNNM; 1.
PE 4: Predicted;
KW CBS domain {ECO:0000256|PROSITE-ProRule:PRU00703};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|PROSITE-ProRule:PRU01193, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001918};
KW Transmembrane {ECO:0000256|PROSITE-ProRule:PRU01193,
KW ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|PROSITE-ProRule:PRU01193,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 6..28
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 49..78
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 98..119
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..205
FT /note="CNNM transmembrane"
FT /evidence="ECO:0000259|PROSITE:PS51846"
FT DOMAIN 281..337
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
SQ SEQUENCE 337 AA; 35620 MW; A8EA96A3D57FC438 CRC64;
MDPLTALVVT VLLLAGNGFF VAAEFALVAA RRPRLERAAR AGSRPARAAV AGISELSLML
AGAQLGITMC TLGLGVVSEP AFEKVLADPL HALGLPESAS HAVALAVALA VVTFLHMVVG
EMAPKSWAIS HPERSALILA LPFRAFARVA RPVLAVMNGM ANGFLRLIRV PPRNEVDTHT
DPQRLGHLLG ESRRLGLIDR RDHDLLGRVI AIREASIAGL TIPAAQVAAV PADAGPLEIR
RAARASGHAR LLVRDRDGTI LGVTHVRDAI TAENGRRAAD MAYPVPELEE ATTVLDAATH
LRRERAQVAV VKAPDGALRG IVSLDDLLGQ LLATNPH
//
