ID D1A768_THECD Unreviewed; 493 AA.
AC D1A768;
DT 19-JAN-2010, integrated into UniProtKB/TrEMBL.
DT 19-JAN-2010, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE SubName: Full=Glutamate--cysteine ligase GCS2 {ECO:0000313|EMBL:ACZ00274.1};
GN OrderedLocusNames=Tcur_4753 {ECO:0000313|EMBL:ACZ00274.1};
OS Thermomonospora curvata (strain ATCC 19995 / DSM 43183 / JCM 3096 / KCTC
OS 9072 / NBRC 15933 / NCIMB 10081 / Henssen B9).
OC Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC Thermomonosporaceae; Thermomonospora.
OX NCBI_TaxID=471852 {ECO:0000313|EMBL:ACZ00274.1, ECO:0000313|Proteomes:UP000001918};
RN [1] {ECO:0000313|EMBL:ACZ00274.1, ECO:0000313|Proteomes:UP000001918}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 19995 / DSM 43183 / JCM 3096 / KCTC 9072 / NBRC 15933 /
RC NCIMB 10081 / Henssen B9 {ECO:0000313|Proteomes:UP000001918};
RX PubMed=21475583; DOI=10.4056/sigs.1453580;
RA Chertkov O., Sikorski J., Nolan M., Lapidus A., Lucas S., Del Rio T.G.,
RA Tice H., Cheng J.F., Goodwin L., Pitluck S., Liolios K., Ivanova N.,
RA Mavromatis K., Mikhailova N., Ovchinnikova G., Pati A., Chen A.,
RA Palaniappan K., Djao O.D., Land M., Hauser L., Chang Y.J., Jeffries C.D.,
RA Brettin T., Han C., Detter J.C., Rohde M., Goker M., Woyke T., Bristow J.,
RA Eisen J.A., Markowitz V., Hugenholtz P., Klenk H.P., Kyrpides N.C.;
RT "Complete genome sequence of Thermomonospora curvata type strain (B9).";
RL Stand. Genomic Sci. 1:13-22(2011).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-cysteine + L-glutamate = ADP + gamma-L-glutamyl-L-
CC cysteine + H(+) + phosphate; Xref=Rhea:RHEA:13285, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:29985, ChEBI:CHEBI:30616, ChEBI:CHEBI:35235,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:58173, ChEBI:CHEBI:456216; EC=6.3.2.2;
CC Evidence={ECO:0000256|ARBA:ARBA00029283};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP001738; ACZ00274.1; -; Genomic_DNA.
DR RefSeq; WP_012855055.1; NC_013510.1.
DR AlphaFoldDB; D1A768; -.
DR STRING; 471852.Tcur_4753; -.
DR KEGG; tcu:Tcur_4753; -.
DR eggNOG; COG2170; Bacteria.
DR HOGENOM; CLU_029030_0_0_11; -.
DR OrthoDB; 240589at2; -.
DR Proteomes; UP000001918; Chromosome.
DR GO; GO:0004357; F:glutamate-cysteine ligase activity; IEA:InterPro.
DR GO; GO:0042398; P:cellular modified amino acid biosynthetic process; IEA:InterPro.
DR Gene3D; 3.30.590.20; -; 1.
DR InterPro; IPR006336; GCS2.
DR InterPro; IPR014746; Gln_synth/guanido_kin_cat_dom.
DR InterPro; IPR016602; UCP012666.
DR PANTHER; PTHR36510:SF3; CONSERVED PROTEIN; 1.
DR PANTHER; PTHR36510; GLUTAMATE--CYSTEINE LIGASE 2-RELATED; 1.
DR Pfam; PF04107; GCS2; 1.
DR PIRSF; PIRSF012666; UCP012666; 1.
DR SUPFAM; SSF55931; Glutamine synthetase/guanido kinase; 1.
PE 4: Predicted;
KW Ligase {ECO:0000313|EMBL:ACZ00274.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001918}.
SQ SEQUENCE 493 AA; 55984 MW; B5DBC974DEDEB872 CRC64;
MGKDVPRFTI SGMDRRRYRD KVRRNLDVLA RMLRESQFEF DRPHIGLEIE LNLVDGRGEP
LMRNADVLKA IADPAWATEL GQFNVEINIP PRELGGGGTG ELERDILGYL KHADGRAREL
GGALMLVGIL PTLRESDLGE ESLSANERYK ILNEQIFAAR GEDMHIDIDG PERLALHIDN
IAPEAACTSA QFHLQVSPDD FAAYWNAAQS IAGVQVALAA NSPFLFGRRL WHETRITLFE
QATDTRPVEL KHQGVRPRVW FGERWITSVF DLFEENTRYF PALLPLCEEE DPVATLERGD
IPQLGELTLH NGTIYRWNRP IYAVVNGKPH LRVENRVLPA GPTVADIVAN GAFYYGLVRT
LAEEERPVWT RMSFRAAEDN LHRAARNGIE TTIYWPGYGE VPVTELTLRK LLPMAHEGLD
RWGVDPAKRD RLLGIIEQRC LTGRNGAIWQ VETARAIEEE RGVDRHEALR LMTCRYIELM
NTNEPVHTWP VEP
//