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Database: UniProt
Entry: D1AL57_SEBTE
LinkDB: D1AL57_SEBTE
Original site: D1AL57_SEBTE 
ID   D1AL57_SEBTE            Unreviewed;       466 AA.
AC   D1AL57;
DT   19-JAN-2010, integrated into UniProtKB/TrEMBL.
DT   19-JAN-2010, sequence version 1.
DT   24-JAN-2024, entry version 62.
DE   RecName: Full=Multidrug export protein MepA {ECO:0000256|ARBA:ARBA00022106};
GN   OrderedLocusNames=Sterm_2347 {ECO:0000313|EMBL:ACZ09200.1};
OS   Sebaldella termitidis (strain ATCC 33386 / NCTC 11300).
OC   Bacteria; Fusobacteriota; Fusobacteriia; Fusobacteriales; Leptotrichiaceae;
OC   Sebaldella.
OX   NCBI_TaxID=526218 {ECO:0000313|EMBL:ACZ09200.1, ECO:0000313|Proteomes:UP000000845};
RN   [1] {ECO:0000313|Proteomes:UP000000845}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 33386 / NCTC 11300 {ECO:0000313|Proteomes:UP000000845};
RG   US DOE Joint Genome Institute (JGI-PGF);
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Bruce D., Goodwin L., Pitluck S., Kyrpides N., Mavromatis K., Ivanova N.,
RA   Mikhailova N., Sims D., Meincke L., Brettin T., Detter J.C., Han C.,
RA   Larimer F., Land M., Hauser L., Markowitz V., Cheng J.F., Hugenholtz P.,
RA   Woyke T., Wu D., Eisen J.A.;
RT   "The complete chromosome of Sebaldella termitidis ATCC 33386.";
RL   Submitted (SEP-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ACZ09200.1, ECO:0000313|Proteomes:UP000000845}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 33386 / NCTC 11300 {ECO:0000313|Proteomes:UP000000845};
RX   PubMed=21304705;
RA   Harmon-Smith M., Celia L., Chertkov O., Lapidus A., Copeland A.,
RA   Glavina Del Rio T., Nolan M., Lucas S., Tice H., Cheng J.F., Han C.,
RA   Detter J.C., Bruce D., Goodwin L., Pitluck S., Pati A., Liolios K.,
RA   Ivanova N., Mavromatis K., Mikhailova N., Chen A., Palaniappan K., Land M.,
RA   Hauser L., Chang Y.J., Jeffries C.D., Brettin T., Goker M., Beck B.,
RA   Bristow J., Eisen J.A., Markowitz V., Hugenholtz P., Kyrpides N.C.,
RA   Klenk H.P., Chen F.;
RT   "Complete genome sequence of Sebaldella termitidis type strain (NCTC
RT   11300).";
RL   Stand. Genomic Sci. 2:220-227(2010).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) (TC
CC       2.A.66.1) family. MepA subfamily. {ECO:0000256|ARBA:ARBA00008417}.
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DR   EMBL; CP001739; ACZ09200.1; -; Genomic_DNA.
DR   RefSeq; WP_012861794.1; NC_013517.1.
DR   AlphaFoldDB; D1AL57; -.
DR   STRING; 526218.Sterm_2347; -.
DR   KEGG; str:Sterm_2347; -.
DR   eggNOG; COG0534; Bacteria.
DR   HOGENOM; CLU_012893_0_2_0; -.
DR   OMA; ICGVRIT; -.
DR   Proteomes; UP000000845; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR   GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR   CDD; cd13143; MATE_MepA_like; 1.
DR   InterPro; IPR002528; MATE_fam.
DR   InterPro; IPR045070; MATE_MepA-like.
DR   InterPro; IPR048279; MdtK-like.
DR   NCBIfam; TIGR00797; matE; 1.
DR   PANTHER; PTHR43823:SF3; MULTIDRUG EXPORT PROTEIN MEPA; 1.
DR   PANTHER; PTHR43823; SPORULATION PROTEIN YKVU; 1.
DR   Pfam; PF01554; MatE; 2.
DR   PIRSF; PIRSF006603; DinF; 1.
PE   3: Inferred from homology;
KW   Antibiotic resistance {ECO:0000256|ARBA:ARBA00023251};
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000845};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   TRANSMEM        20..37
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        57..82
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        94..116
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        136..155
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        167..191
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        197..216
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        250..275
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        287..309
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        330..353
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        379..397
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        409..429
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        435..455
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   466 AA;  52136 MW;  654F0A6CDD203447 CRC64;
     MRRKQSELET ESVGKLLRKY TIPALIGNIV IVVYNFVDRW FIGQFIGEEA LAASGITFYL
     LMVFIAFSML IGIGAGTIIS IRLGQKNIED SEKILGNSVT LFFIVSIILT VILWFNLDFI
     LLKSGANNET LPYARAYMRI LIPISLANFY SYGLSNVMRA ANAPKTAMFA MIIGGVVNLV
     LDYIFVVLFH MGIEGTAYAT LIGNVLSAVY VMYFFIRGKP LFRLNMFGRS IDEASILRLR
     KKHLPLSYKI SYDILKIGMS SFLLQSVNAA VGVVINNVIS STGGTTGVAI MTIINTYLTL
     IVMSVYSIAQ GAQPIIGYNY GAKRFDRVKA SFNMSIIWGL IMSAVFFLVI MLIPRELILL
     FNKDSNSNVI HDGIKAMRIY FMLIIPASVG TIVPNYFQSI GNAREAIILN IMRQVFIFMI
     VMLIFTRIWG LDGVWYAQPV TDVIFTFIVG VLLVIENKKL SKEIMK
//
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