ID D1C2B0_SPHTD Unreviewed; 658 AA.
AC D1C2B0;
DT 19-JAN-2010, integrated into UniProtKB/TrEMBL.
DT 19-JAN-2010, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE SubName: Full=DNA polymerase III, epsilon subunit {ECO:0000313|EMBL:ACZ38377.1};
DE EC=2.7.7.7 {ECO:0000313|EMBL:ACZ38377.1};
GN OrderedLocusNames=Sthe_0940 {ECO:0000313|EMBL:ACZ38377.1};
OS Sphaerobacter thermophilus (strain DSM 20745 / S 6022).
OC Bacteria; Thermomicrobiota; Thermomicrobia; Sphaerobacterales;
OC Sphaerobacterineae; Sphaerobacteraceae; Sphaerobacter.
OX NCBI_TaxID=479434 {ECO:0000313|EMBL:ACZ38377.1, ECO:0000313|Proteomes:UP000002027};
RN [1] {ECO:0000313|Proteomes:UP000002027}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 49802 / DSM 20745 / S 6022
RC {ECO:0000313|Proteomes:UP000002027};
RA Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA Bruce D., Goodwin L., Pitluck S., Kyrpides N., Mavromatis K., Ivanova N.,
RA Mikhailova N., LaButti K.M., Clum A., Sun H.I., Brettin T., Detter J.C.,
RA Han C., Larimer F., Land M., Hauser L., Markowitz V., Cheng J.F.,
RA Hugenholtz P., Woyke T., Wu D., Steenblock K., Schneider S., Pukall R.,
RA Goeker M., Klenk H.P., Eisen J.A.;
RT "The complete chromosome 1 of Sphaerobacter thermophilus DSM 20745.";
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ACZ38377.1, ECO:0000313|Proteomes:UP000002027}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 49802 / DSM 20745 / S 6022
RC {ECO:0000313|Proteomes:UP000002027};
RX PubMed=21304676;
RA Spring S., Nolan M., Lapidus A., Glavina Del Rio T., Copeland A., Tice H.,
RA Cheng J.F., Lucas S., Land M., Chen F., Bruce D., Goodwin L., Pitluck S.,
RA Ivanova N., Mavromatis K., Mikhailova N., Pati A., Chen A., Palaniappan K.,
RA Hauser L., Chang Y.J., Jeffries C.D., Munk C., Kiss H., Chain P., Han C.,
RA Brettin T., Detter J.C., Schuler E., Goker M., Rohde M., Bristow J.,
RA Eisen J.A., Markowitz V., Hugenholtz P., Kyrpides N.C., Klenk H.P.;
RT "Complete genome sequence of Desulfohalobium retbaense type strain
RT (HR(100)).";
RL Stand. Genomic Sci. 2:38-48(2010).
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DR EMBL; CP001823; ACZ38377.1; -; Genomic_DNA.
DR RefSeq; WP_012871424.1; NC_013523.1.
DR AlphaFoldDB; D1C2B0; -.
DR STRING; 479434.Sthe_0940; -.
DR KEGG; sti:Sthe_0940; -.
DR eggNOG; COG0322; Bacteria.
DR eggNOG; COG0847; Bacteria.
DR HOGENOM; CLU_397351_0_0_0; -.
DR InParanoid; D1C2B0; -.
DR Proteomes; UP000002027; Chromosome 1.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-EC.
DR GO; GO:0004527; F:exonuclease activity; IEA:UniProt.
DR GO; GO:0006260; P:DNA replication; IEA:InterPro.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR CDD; cd06127; DEDDh; 1.
DR CDD; cd10434; GIY-YIG_UvrC_Cho; 1.
DR Gene3D; 3.40.1440.10; GIY-YIG endonuclease; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR Gene3D; 4.10.860.10; UVR domain; 1.
DR InterPro; IPR006054; DnaQ.
DR InterPro; IPR013520; Exonuclease_RNaseT/DNA_pol3.
DR InterPro; IPR000305; GIY-YIG_endonuc.
DR InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR InterPro; IPR047296; GIY-YIG_UvrC_Cho.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR001943; UVR_dom.
DR InterPro; IPR036876; UVR_dom_sf.
DR NCBIfam; TIGR00573; dnaq; 1.
DR PANTHER; PTHR30562:SF1; UVRABC SYSTEM PROTEIN C; 1.
DR PANTHER; PTHR30562; UVRC/OXIDOREDUCTASE; 1.
DR Pfam; PF01541; GIY-YIG; 1.
DR Pfam; PF00929; RNase_T; 1.
DR Pfam; PF02151; UVR; 1.
DR SMART; SM00479; EXOIII; 1.
DR SMART; SM00465; GIYc; 1.
DR SUPFAM; SSF46600; C-terminal UvrC-binding domain of UvrB; 1.
DR SUPFAM; SSF82771; GIY-YIG endonuclease; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS50164; GIY_YIG; 1.
DR PROSITE; PS50151; UVR; 1.
PE 4: Predicted;
KW Nucleotidyltransferase {ECO:0000313|EMBL:ACZ38377.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000002027};
KW Transferase {ECO:0000313|EMBL:ACZ38377.1}.
FT DOMAIN 296..375
FT /note="GIY-YIG"
FT /evidence="ECO:0000259|PROSITE:PS50164"
FT DOMAIN 487..522
FT /note="UVR"
FT /evidence="ECO:0000259|PROSITE:PS50151"
SQ SEQUENCE 658 AA; 73557 MW; BB15DA3D50D51501 CRC64;
MAAGSEARDD PYAGLRQRAY LFLRERDGAV PEEELIEHVF GSSGNPALWR PLLRQVLGAD
DRLDLRADGY WALRGTAPVS NGLLPTDFVV IDIETTGLRP LRQRIIEVAA IRYRGGRRQG
VFSTLVNPER PVPAYIRKLT GIDETALAGA PVFRRVADEL TAFLGDDLLI GYNVEFDIAF
LNAELKRLGR PPLINPRLDL LPLSTQLIPG MRRSGLDAAC LALGLEFRER HRAEADAALT
ALLLARLGEL ARERGLTTFD GLQRAAATRV PVPKRRGPVG RGRAVLDRSH LEGIPHAPGV
YLMYGARERV IYVGKAKDLR NRVSSYYSQP LGYTRKMDGL LESIERIEVV ETGSELEALL
LEAQFIRRYR PQYNTQMRNN EAYPYIKIDI GNPWPRVTLT RQRADDGAVY FGPFRVARSA
RETVDLINEV FPLRTCARSF RTARSYGSPC LRLSLGQCLG PCTGMVDRDA YRQAVQDVIG
FLRGGRDEVM ARLHQELVAC AERLDFERAS RLRDRIRRVQ QLVLSQQLLA ETEQRGTVLI
VTPSPESGAR EFLLVVRGRL WAQIRAAAGA TDDDVAARLA RSWERAQQTT MPAVDQDSLD
QVHLLGRWLR KYAGHRAIIP LDAVPNWVAL VAQGRALTDD ELSFDSRPAP VSEEPLPA
//
