ID D1CIG6_THET1 Unreviewed; 1712 AA.
AC D1CIG6;
DT 19-JAN-2010, integrated into UniProtKB/TrEMBL.
DT 19-JAN-2010, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN OrderedLocusNames=Tter_2649 {ECO:0000313|EMBL:ACZ43537.1};
OS Thermobaculum terrenum (strain ATCC BAA-798 / YNP1).
OC Bacteria; Chloroflexota; Thermobaculum.
OX NCBI_TaxID=525904 {ECO:0000313|EMBL:ACZ43537.1, ECO:0000313|Proteomes:UP000000323};
RN [1] {ECO:0000313|EMBL:ACZ43537.1, ECO:0000313|Proteomes:UP000000323}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-798 / YNP1 {ECO:0000313|Proteomes:UP000000323};
RX PubMed=21304745;
RA Kiss H., Cleland D., Lapidus A., Lucas S., Del Rio T.G., Nolan M., Tice H.,
RA Han C., Goodwin L., Pitluck S., Liolios K., Ivanova N., Mavromatis K.,
RA Ovchinnikova G., Pati A., Chen A., Palaniappan K., Land M., Hauser L.,
RA Chang Y.J., Jeffries C.D., Lu M., Brettin T., Detter J.C., Goker M.,
RA Tindall B.J., Beck B., McDermott T.R., Woyke T., Bristow J., Eisen J.A.,
RA Markowitz V., Hugenholtz P., Kyrpides N.C., Klenk H.P., Cheng J.F.;
RT "Complete genome sequence of 'Thermobaculum terrenum' type strain (YNP1).";
RL Stand. Genomic Sci. 3:153-162(2010).
RN [2] {ECO:0000313|Proteomes:UP000000323}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-798 / YNP1 {ECO:0000313|Proteomes:UP000000323};
RX DOI=10.4056/sigs.1153107;
RA Kiss H., Cleland D., Lapidus A., Lucas S., Glavina Del Rio T., Nolan M.,
RA Tice H., Han C., Goodwin L., Pitluck S., Liolios K., Ivanova N.,
RA Mavromatis K., Ovchinnikova G., Pati A., Chen A., Palaniappan K., Land M.,
RA Hauser L., Chang Y., Jeffries C., Lu M., Brettin T., Detter J., Goker M.,
RA Tindall B., Beck B., McDermott T., Woyke T., Bristow J., Eisen J.,
RA Markowitz V., Hugenholtz P., Kyrpides N., Klenk H., Cheng J.;
RT "Complete genome sequence of Thermobaculum terrenum type strain (YNP1T).";
RL Stand. Genomic Sci. 3:153-162(2010).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
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DR EMBL; CP001826; ACZ43537.1; -; Genomic_DNA.
DR RefSeq; WP_012876568.1; NC_013526.1.
DR STRING; 525904.Tter_2649; -.
DR REBASE; 23004; Tte798ORF2649P.
DR KEGG; ttr:Tter_2649; -.
DR eggNOG; COG1002; Bacteria.
DR eggNOG; COG2852; Bacteria.
DR HOGENOM; CLU_002881_0_0_0; -.
DR OrthoDB; 32195at2; -.
DR Proteomes; UP000000323; Chromosome 2.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR CDD; cd01038; Endonuclease_DUF559; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR Gene3D; 3.40.960.10; VSR Endonuclease; 1.
DR InterPro; IPR003356; DNA_methylase_A-5.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR007569; DUF559.
DR InterPro; IPR047216; Endonuclease_DUF559_bact.
DR InterPro; IPR011335; Restrct_endonuc-II-like.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR33841:SF1; ADENINE-SPECIFIC METHYLTRANSFERASE PGLX; 1.
DR PANTHER; PTHR33841; DNA METHYLTRANSFERASE YEEA-RELATED; 1.
DR Pfam; PF04480; DUF559; 1.
DR Pfam; PF02384; N6_Mtase; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF52980; Restriction endonuclease-like; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Reference proteome {ECO:0000313|Proteomes:UP000000323};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 477..599
FT /note="DNA methylase adenine-specific"
FT /evidence="ECO:0000259|Pfam:PF02384"
FT DOMAIN 1182..1284
FT /note="DUF559"
FT /evidence="ECO:0000259|Pfam:PF04480"
FT REGION 437..457
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1077..1179
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1286..1400
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1429..1454
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1685..1704
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1322..1381
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1436..1450
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1712 AA; 192265 MW; 66AE972A004EC14F CRC64;
MAYTTITIEG GLFPSDLLDR LVPQAGATLE GQKPADFGCQ DLSALLADMQ AAFNDMRTYW
ESFQRRLQHA SGTSHTSVTR ESWVLPVLEL LGFAEVRYVQ AATAVGQETY NISHFYGDVP
IHIVGCHQQL DQRLVGRERR SPHSTVQEYL NRSDALWGIV TNGLRLRLLR DSALVSHPVY
LEFDLEAMVR GELYSEFVLL YRLLHSTRFP RPGSPPNECL LERYYQQGIE EGGRVRERLR
EGVERALGIL GRALLAHPES VALREAMVSG ELSPVGYYRE LLRLIYRLLF LFVVEERRLL
LPPAEDERTR RLHEVYLQHY SASRLRARSE AHHAGDTYCD LWHGLMRTFE LLRDDERARK
LGMSALNGEL FGPNACAHIE RAVCTNQDLL DAIASLTLFQ DEGTYRRVNF AWLDVEELGS
VYESLLDYHP RVEITPAGTD AQGAVTPPER KAGESSPARI EASAGVICSF ELVMGSERKQ
TGSYYTPPSL VRQLIKTALE PVIEQRLKEA GHDRQRQEEA LLNLRVCDPA SGSGHFLLAA
ARRIARELAR VRTGEEEPSP QAYRQALRDV IRECIYAVDK NPLAVDLCKV ALWIEGYNTG
MPLSFLDNHI KCGDSLVGIF DIQALVEGVP DGAYEAVEGD SKAIASAIRK RNKEERLQST
LWGASSVPDI TDIARDFAQL STLAESTPEE VRRKEQCYSN LRKPSTRWWD LKVACDLWTY
AFFAPLRSGE PVSTTTNVWA ALERSGKDPQ VEGQAIAYSQ EHPFFHWPLE FPEVFDRGGF
DVVLGNPPWE RLKLQQQEFF ASRDLQIAKA RNKAERNKLI KQLPQTNPEL AREYDRALHA
SEAQSKFVRL SGRFPLCGRG DVNTYSVFAE NFLQLMSPKG RAGLIVPTGI ATDDTNKHFF
AELVRTGRLA SLYDFENKGI FPAVDDRYKF CLLTLGGDGQ RSSAAEFAFF LHSVEELEGG
SPEVLAARGT PSQGASGAPA APAADKRFIL TPEEISLINP NTRTCPIFRS RRDAELTLDI
YRRVPVLVRE GPPEENPWGV SFLRMFDMSN DSHLFRTRGE LEAAGYTLVG NVFVRRASHP
TPRPEGDGSD GPAPASPSGH GDPARPTAAT QPMGEEGKNQ TSPEPRSGHE PHNHSSHGYI
SARNGGFEGQ IAPPSLGRRG DRSSHSSSHP MWLGREGVPT PRAREFRRAS TRSKELLWHV
LRGLQVDGYR FRRQHPFGPF ILEFYCPEAR LAIEVDGPIP GERREVALER QRWLERHGLQ
VIRVSPEEVE HSLPTVVRKI RAKLSQRLSQ AAPLPGRSED GHTPSRPIAA NTAARSAGPD
TEDIGNASTN NRPTQHVGSN SGTEPGSTAT MSAAGNEPAL SAQASTTGTT QADNSPHAPL
TSEEGGQEEE ATPARPAENW ESDDVYLPLY EGKMLQQFNH RWATYQPMPA SAHSKRMAKT
KKDGAERNST PDELADPNFV VIPQYWVAAS EVSKRLSGRW PYRWLVAFRD ITNSTNERTA
IFSFIPRVAV GNTAPLVMTS KTENTTKLTS YLANTNSFLF DYVARQKVGG THLTFTLLNQ
FPVLPPSTYE RQAPWDGGVT LAEWITPRVM ELVYTAWDLR PFAQDMGYDC PPFRWDKERR
FILRCELDAA YFHLYGIRRE DVDYIMETFP IVRRRDMEQH GEYRTKRVIL EIYDEMERCM
QTDAPYTTRL HPPPADPSLT HPWDRRAVRE GA
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