GenomeNet

Database: UniProt
Entry: D1GY43
LinkDB: D1GY43
Original site: D1GY43 
ID   UBA5_DROAN              Reviewed;         396 AA.
AC   D1GY43; B3MAM7; D1GY50;
DT   02-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT   02-MAR-2010, sequence version 2.
DT   16-JAN-2019, entry version 43.
DE   RecName: Full=Ubiquitin-like modifier-activating enzyme 5;
DE            Short=Ubiquitin-activating enzyme 5;
GN   ORFNames=GF23479;
OS   Drosophila ananassae (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
OC   Ephydroidea; Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7217;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS ALA-373 AND GLY-373.
RC   STRAIN=BKK11, BKK13, BKK16, BKK4, BKK5, BKK7, BKK8, and BKK9;
RX   PubMed=20015359; DOI=10.1186/1471-2148-9-291;
RA   Grath S., Baines J.F., Parsch J.;
RT   "Molecular evolution of sex-biased genes in the Drosophila ananassae
RT   subgroup.";
RL   BMC Evol. Biol. 9:291-291(2009).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 14024-0371.13;
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: E1-like enzyme which activates UFM1. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ubiquitin-activating E1 family. UBA5
CC       subfamily. {ECO:0000305}.
DR   EMBL; FN546432; CBE66731.1; -; Genomic_DNA.
DR   EMBL; FN546433; CBE66732.1; -; Genomic_DNA.
DR   EMBL; FN546434; CBE66733.1; -; Genomic_DNA.
DR   EMBL; FN546435; CBE66734.1; -; Genomic_DNA.
DR   EMBL; FN546436; CBE66735.1; -; Genomic_DNA.
DR   EMBL; FN546437; CBE66736.1; -; Genomic_DNA.
DR   EMBL; FN546438; CBE66737.1; -; Genomic_DNA.
DR   EMBL; FN546439; CBE66738.1; -; Genomic_DNA.
DR   EMBL; CH902618; EDV41314.1; -; Genomic_DNA.
DR   RefSeq; XP_001958508.1; XM_001958472.2.
DR   SMR; D1GY43; -.
DR   STRING; 7217.FBpp0126671; -.
DR   PRIDE; D1GY43; -.
DR   EnsemblMetazoa; FBtr0128179; FBpp0126671; FBgn0100473.
DR   GeneID; 6506120; -.
DR   KEGG; dan:Dana_GF23479; -.
DR   FlyBase; FBgn0100473; Dana\GF23479.
DR   eggNOG; KOG2336; Eukaryota.
DR   eggNOG; COG0476; LUCA.
DR   InParanoid; D1GY43; -.
DR   KO; K12164; -.
DR   OMA; ETHNYNI; -.
DR   OrthoDB; 1092362at2759; -.
DR   PhylomeDB; D1GY43; -.
DR   Proteomes; UP000007801; Unassembled WGS sequence.
DR   Bgee; FBgn0100473; Expressed in 1 organ(s), highest expression level in adult organism.
DR   GO; GO:0019008; C:molybdopterin synthase complex; IEA:EnsemblMetazoa.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0008641; F:ubiquitin-like modifier activating enzyme activity; IEA:InterPro.
DR   GO; GO:0050905; P:neuromuscular process; IEA:EnsemblMetazoa.
DR   InterPro; IPR029752; D-isomer_DH_CS1.
DR   InterPro; IPR000594; ThiF_NAD_FAD-bd.
DR   InterPro; IPR035985; Ubiquitin-activating_enz.
DR   Pfam; PF00899; ThiF; 1.
DR   SUPFAM; SSF69572; SSF69572; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Metal-binding; Nucleotide-binding;
KW   Reference proteome; Ubl conjugation pathway; Zinc.
FT   CHAIN         1    396       Ubiquitin-like modifier-activating enzyme
FT                                5.
FT                                /FTId=PRO_0000391941.
FT   ACT_SITE    243    243       Glycyl thioester intermediate.
FT                                {ECO:0000250}.
FT   METAL       219    219       Zinc. {ECO:0000250}.
FT   METAL       222    222       Zinc. {ECO:0000250}.
FT   METAL       296    296       Zinc. {ECO:0000250}.
FT   METAL       301    301       Zinc. {ECO:0000250}.
FT   BINDING      76     76       ATP; via amide nitrogen. {ECO:0000250}.
FT   BINDING      97     97       ATP. {ECO:0000250}.
FT   BINDING     120    120       ATP. {ECO:0000250}.
FT   BINDING     143    143       ATP. {ECO:0000250}.
FT   BINDING     177    177       ATP. {ECO:0000250}.
FT   VARIANT     373    373       E -> A (in strain: BKK11, BKK13, BKK16,
FT                                BKK4, BKK5, BKK7 and BKK8).
FT                                {ECO:0000269|PubMed:20015359}.
FT   VARIANT     373    373       E -> G (in strain: BKK9).
FT                                {ECO:0000269|PubMed:20015359}.
SQ   SEQUENCE   396 AA;  43896 MW;  39DBC40209A837CA CRC64;
     MSHAIDELQA IIAELKVELE EQKTSNRQAR SRIDRMSAEV VDSNPYSRLM ALQRMNIVKE
     YERIRDKAVA VVGVGGVGSV TADMLTRCGI GKLILFDYDK VELANMNRLF FTPDQAGLSK
     VEAAARTLNF INPDVQIETH NYNITTVDNF DRFLATITES GKELGQPVDL VLSCVDNFEA
     RMAINAACNE RNLNWFESGV SENAVSGHIQ FIRPGDTACF ACAPPLVVAE NIDEKTLKRE
     GVCAASLPTT MGITAGFLVQ NALKYLLNFG EVSDYLGYNA LNDFFPRMTL KPNPQCDDRN
     CLLRQKEFQA RPKPIEVKED VSSSDEPLHA TNEWGIELVA DDEPVNCPEP AKSSAVVQGL
     KLAYEAPEKE KVEEENVATV SDETSLEDLM AQMKSM
//
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