ID D1NTB4_9BIFI Unreviewed; 1525 AA.
AC D1NTB4;
DT 09-FEB-2010, integrated into UniProtKB/TrEMBL.
DT 09-FEB-2010, sequence version 1.
DT 27-MAR-2024, entry version 74.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=BGLCM_1399 {ECO:0000313|EMBL:KFI57709.1}, BIFGAL_03071
GN {ECO:0000313|EMBL:EFA22968.1};
OS Bifidobacterium gallicum DSM 20093 = LMG 11596.
OC Bacteria; Actinomycetota; Actinomycetes; Bifidobacteriales;
OC Bifidobacteriaceae; Bifidobacterium.
OX NCBI_TaxID=561180 {ECO:0000313|EMBL:EFA22968.1, ECO:0000313|Proteomes:UP000003656};
RN [1] {ECO:0000313|EMBL:EFA22968.1, ECO:0000313|Proteomes:UP000003656}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 20093 {ECO:0000313|EMBL:EFA22968.1,
RC ECO:0000313|Proteomes:UP000003656};
RA Weinstock G., Sodergren E., Clifton S., Fulton L., Fulton B., Courtney L.,
RA Fronick C., Harrison M., Strong C., Farmer C., Delahaunty K., Markovic C.,
RA Hall O., Minx P., Tomlinson C., Mitreva M., Nelson J., Hou S., Wollam A.,
RA Pepin K.H., Johnson M., Bhonagiri V., Nash W.E., Warren W., Chinwalla A.,
RA Mardis E.R., Wilson R.K.;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:KFI57709.1, ECO:0000313|Proteomes:UP000029074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LMG 11596 {ECO:0000313|EMBL:KFI57709.1,
RC ECO:0000313|Proteomes:UP000029074};
RA Ventura M., Milani C., Lugli G.A.;
RT "Genomics of Bifidobacteria.";
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFA22968.1}.
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DR EMBL; ABXB03000002; EFA22968.1; -; Genomic_DNA.
DR EMBL; JGYW01000009; KFI57709.1; -; Genomic_DNA.
DR RefSeq; WP_006294487.1; NZ_JGYW01000009.1.
DR STRING; 561180.BIFGAL_03071; -.
DR eggNOG; COG0210; Bacteria.
DR eggNOG; COG2887; Bacteria.
DR OrthoDB; 5240387at2; -.
DR Proteomes; UP000003656; Unassembled WGS sequence.
DR Proteomes; UP000029074; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038726; PDDEXK_AddAB-type.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF59; DNA HELICASE; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF12705; PDDEXK_1; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}.
FT DOMAIN 35..396
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 410..681
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT REGION 999..1032
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1062..1087
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1006..1032
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 56..63
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 1525 AA; 166932 MW; DAA5F608133FA85B CRC64;
MHAKLNIGTG SSDSYGQFWL ESQCWEGLLQ QRTHNTHARE TGSEATQSAA IRLVVGPPAS
GKTRTLFTHM VDACRTEGDD RVVMAVTNRQ IADALSDDLI RQLGVTSQAR PVTTLNAVAF
RLITEQRERE NRTLPRLING AEQDLLLRRV LGRHIAQAQA GETCATCEQL RAYFEQDHWE
RVICNQSAPV DAAAPTAAQT LAQETPDMSG SNANANVLTL QPQTTASLFL EGIDGEFIAQ
MRDMLARMAE IGLTDVQESE YLDAVRDTGL TGERLRTQWH LAWALRREYA SEVARAFPHE
YRLDPSELLG AAARLVRDQA EPPMLRELIM DDVQDLTLAG LAFLQALASR GVRLTLAGNP
DESVQTFRGS YPEYVFRVLR DQMHAQVTHL QPLRHDSSPS VTPTMLDTVA SRVSLSIEAI
EPTDTAMPHR LGKLPAHEGA WPIRTLDNTD ARLLDGTFKG LVYRSAQEEE DNVVWRIKSL
HLDHAVPWNN IAVIMHDNAA IRTLGARLRR DGVPVRFSSV TRALIEEPFV QALFALIELA
QMRNAGIARS GMGERQAVAW VASRVRSIAA SALLQPAGRA QDTADQPLHL ETIETAMQAI
DSLSSVVKHA PAATDSTLLT SLEEQWQALH ADFVASARQH HDDFPTLTID NSNFDESARN
EEPLSFGSDA MTLMLMHDGA PKLLDALQLI MGQSRTIMMY RRLWSLVHTI AQQFATQPRM
MPADALACAW NATNVAKRWQ TAAFTNNAAG RAANDRLDVA MRLFEYANGA SEGTTITAFI
DQVRQLQIEA DSLAKVAPID QAVTLTTPAG AAGRHWTHVF MPAVQEGTWP NLVPRGTMFG
GDDLVQVALY GAPTFMRETQ GGQHDLAVRE VLANEQKSFL VALTRVDPTA QGGSVWLSAV
ASEDTAPSEF LFAYAPEWFN DRENPYWQPL QRLAAMGETD DTDHVAAQQL KDLNEDARGI
IALARMVLTD ETASLNDPRV RDAAMALARL AAGGVSAADP ANWPFVDDTQ SDTMQSDTTA
QSNATLPAGD NTVGNTAANA SMASAASVAR AASIMMPTSM DATDSATAAQ SGPTMPSMQQ
SAAAQPSAAA QSSVAAAMRP HDAASSTVLA TANGMQTVVL SPSQVDSYWE CPICAKLDKV
YAGPQRGSVS TSFGTIIHDV AAHATEQHWD NPKPDSDLTK LGQDARIKAI SDLMMTEFEQ
RMAAEPEPKT AKERYTMQQD KLRAHDVLYA IARYFVLSDQ ADYPAYKGCP PLGKLVQSHA
ESPFRASFTL ADVLDAYNAM PEVDAIDEST LIAMMGVLVD GWPQVTPQGL RIELTGRIDR
EEWREQPDGT HTLRIVDYKT GHRRTGPEQF QDLQLICYQL GFAFPSNEQG RRVRDLQHMP
VITQCDLFYP TDKDGKLQLP AQSRSAEALS QPALFKRGAL NSSAYEPRPY FKELSALFDI
SLPQEAPEGV PDEAWQQFLA LRGTFAIWAL TMIARVCYAA AASVSEQLTA HPVAGHMSYC
SRSVNHTICP ACGQGADTVF ETRRG
//
