ID D1PLS4_9FIRM Unreviewed; 1094 AA.
AC D1PLS4;
DT 09-FEB-2010, integrated into UniProtKB/TrEMBL.
DT 09-FEB-2010, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=SUBVAR_05291 {ECO:0000313|EMBL:EFB76372.1};
OS Subdoligranulum variabile DSM 15176.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Oscillospiraceae;
OC Subdoligranulum.
OX NCBI_TaxID=411471 {ECO:0000313|EMBL:EFB76372.1, ECO:0000313|Proteomes:UP000003438};
RN [1] {ECO:0000313|EMBL:EFB76372.1, ECO:0000313|Proteomes:UP000003438}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 15176 {ECO:0000313|EMBL:EFB76372.1,
RC ECO:0000313|Proteomes:UP000003438};
RA Weinstock G., Sodergren E., Clifton S., Fulton L., Fulton B., Courtney L.,
RA Fronick C., Harrison M., Strong C., Farmer C., Delahaunty K., Markovic C.,
RA Hall O., Minx P., Tomlinson C., Mitreva M., Nelson J., Hou S., Wollam A.,
RA Pepin K.H., Johnson M., Bhonagiri V., Nash W.E., Warren W., Chinwalla A.,
RA Mardis E.R., Wilson R.K.;
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFB76372.1}.
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DR EMBL; ACBY02000021; EFB76372.1; -; Genomic_DNA.
DR AlphaFoldDB; D1PLS4; -.
DR STRING; 411471.SUBVAR_05291; -.
DR eggNOG; COG3857; Bacteria.
DR HOGENOM; CLU_007838_0_0_9; -.
DR Proteomes; UP000003438; Unassembled WGS sequence.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR Gene3D; 3.90.320.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR InterPro; IPR049035; ADDB_N.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011604; PDDEXK-like_dom_sf.
DR InterPro; IPR038726; PDDEXK_AddAB-type.
DR PANTHER; PTHR30591; RECBCD ENZYME SUBUNIT RECC; 1.
DR PANTHER; PTHR30591:SF1; RECBCD ENZYME SUBUNIT RECC; 1.
DR Pfam; PF21445; ADDB_N; 1.
DR Pfam; PF12705; PDDEXK_1; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 4: Predicted;
KW 4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000003438}.
FT DOMAIN 252..536
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
SQ SEQUENCE 1094 AA; 119657 MW; 8A448FCC5AF29D35 CRC64;
MLAELRTRAE HGERSLLIVP EQFTSSTEGQ LYRTLGDTLS AYVESYSFTS LAETLLRRYG
GAAVQTLDEA GRALLVRRAV DSLLDQVVYY NRQRRSAAFC EKAAQTIEEL KSAGVTPQAL
AAYACAPGAD RDKLQELSLI YGAYEGLLAQ TAMDPGDRQQ LAAQYLDAAF FAGRAVFIDE
FDTFNAPKRA LLAAMLPVAD VTVCLCCDGP EDHEGGMGLF SGAKAVAGSL RRMAADAGVP
VHTETLTDDP RHADTPVLAE LNLLLADPTY TPDRTVDPDQ PAIVCYGAAS RQAEAKAVAA
EIAARARAGM PYHRMAVICR DAAQYLGPLR YEFRLQNIPL FCDEATTPEN TAPARAVHAV
LDLARSGVSS RTVLRLLKTG LVNLPERQQT ALENYAYTWS LKAADWRAPF TRSAAGYADV
ERAEDVRTRE EAEAARVFLM ERIQKFLPRV KNAGAAALTK QVYLFLQSLG AEDTLNALAE
TLRGQGRMPE ADEVLREWNV VMGLLNQLAQ LLGEEELPPA DYAELFTLLL RTTDMGHIPQ
SLDSVILTTA GRMRLPETDA VFVVGLLEGE FPKTPGDQGL LTHADRDAMI RQGAELPDCF
ENKVLREGVC FYKAMTAARS FLWLSWPGAA HAEDDTPASS ALAPVRRLLQ VPFAGPSTAE
LGASPAAALD ILGVISQQPG REGEGEALRA ALEDAEGTPQ SAPGYEAVRR AREKAEPAVR
DTGALEKLLG PGLRVSPTRF EKYQTCPFGY FMQFVLRAAP RQKAELAPNI SGTLTHWVLE
NALRRQGAAF KDLTAEELQA LVEELVAEYT QANLPGITVR MQYLIERIRR NLVGLLGFIQ
RDLQQSGFQP VAFELRIDDR PGEDPEAPRI DPVELKDGAG HTVRIVGTVD RVDAMPLGER
TYLRVVDYKT GGKDFQLKEV YCGLDCQMLL YLFTLERNAG NKFPGATAAG VEYLLADPAP
ESIPRSEAGQ DAAEAENNYP LNGLLLDDES VYQAMDRRCT GNFVPLNFSA KTGKVTNGKS
RLADEKKLAR IRDHLDGLLK QMSRNLYAGK IDAQPLCNGG RSPCTYCDFR IACAHRDGEN
ERKVEAAADP FAEE
//
