ID D1VXR2_9BACT Unreviewed; 480 AA.
AC D1VXR2;
DT 09-FEB-2010, integrated into UniProtKB/TrEMBL.
DT 09-FEB-2010, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE RecName: Full=glycine dehydrogenase (aminomethyl-transferring) {ECO:0000256|ARBA:ARBA00012134};
DE EC=1.4.4.2 {ECO:0000256|ARBA:ARBA00012134};
GN ORFNames=HMPREF9019_1896 {ECO:0000313|EMBL:EFA97985.1};
OS Hoylesella timonensis CRIS 5C-B1.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Prevotellaceae;
OC Hoylesella.
OX NCBI_TaxID=679189 {ECO:0000313|EMBL:EFA97985.1, ECO:0000313|Proteomes:UP000004001};
RN [1] {ECO:0000313|EMBL:EFA97985.1, ECO:0000313|Proteomes:UP000004001}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CRIS 5C-B1 {ECO:0000313|EMBL:EFA97985.1,
RC ECO:0000313|Proteomes:UP000004001};
RA Durkin A.S., Madupu R., Torralba M., Methe B., Sutton G., Strausberg R.L.,
RA Nelson K.E.;
RT "Genome Sequence of Prevotella timonensis CRIS 5C-B1.";
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: The glycine cleavage system catalyzes the degradation of
CC glycine. The P protein binds the alpha-amino group of glycine through
CC its pyridoxal phosphate cofactor; CO(2) is released and the remaining
CC methylamine moiety is then transferred to the lipoamide cofactor of the
CC H protein. {ECO:0000256|ARBA:ARBA00003788}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=glycine + H(+) + N(6)-[(R)-lipoyl]-L-lysyl-[glycine-cleavage
CC complex H protein] = CO2 + N(6)-[(R)-S(8)-aminomethyldihydrolipoyl]-
CC L-lysyl-[glycine-cleavage complex H protein]; Xref=Rhea:RHEA:24304,
CC Rhea:RHEA-COMP:10494, Rhea:RHEA-COMP:10495, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16526, ChEBI:CHEBI:57305, ChEBI:CHEBI:83099,
CC ChEBI:CHEBI:83143; EC=1.4.4.2;
CC Evidence={ECO:0000256|ARBA:ARBA00043839};
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFA97985.1}.
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DR EMBL; ADEF01000015; EFA97985.1; -; Genomic_DNA.
DR RefSeq; WP_008122772.1; NZ_ADEF01000015.1.
DR AlphaFoldDB; D1VXR2; -.
DR eggNOG; COG1003; Bacteria.
DR Proteomes; UP000004001; Unassembled WGS sequence.
DR GO; GO:0004375; F:glycine dehydrogenase (decarboxylating) activity; IEA:UniProtKB-EC.
DR GO; GO:0006546; P:glycine catabolic process; IEA:InterPro.
DR Gene3D; 6.20.440.10; -; 1.
DR Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR InterPro; IPR049316; GDC-P_C.
DR InterPro; IPR049315; GDC-P_N.
DR InterPro; IPR020581; GDC_P.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR PANTHER; PTHR11773:SF1; GLYCINE DEHYDROGENASE (DECARBOXYLATING), MITOCHONDRIAL; 1.
DR PANTHER; PTHR11773; GLYCINE DEHYDROGENASE, DECARBOXYLATING; 1.
DR Pfam; PF21478; GcvP2_C; 1.
DR Pfam; PF02347; GDC-P; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:EFA97985.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000004001}.
FT DOMAIN 27..297
FT /note="Glycine cleavage system P-protein N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02347"
FT DOMAIN 344..442
FT /note="Glycine dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF21478"
SQ SEQUENCE 480 AA; 53056 MW; F8D123FD5149400E CRC64;
MNHQLYHNLI FELSHPGRRG YTLPKNEFGR HEIPATLKRT VDAELPECDE LTVVRHYTNH
SENNFGVDNG FYPLGSCTMK YNPTINEEIA AHPAFVNLHP LQPAETVQGA KEVYENLQQA
LSALTGLSRF TLNPCAGAHG ELTGLMIISA YHQANNDTKR TKIIVPDSAH GTNPASAAVC
GLEVVEVKST ADGLVDVEHL KTLLGDDIAG MMMTNPNTLG LFETHIPEIT KLIHDCGGLM
YYDGANLNPL LGECRPGDMG FDVMHINLHK TFSTPHGGGG PGSGPVGVCE KLVDFLPTNN
CATNAKGHFT ITVHPYHGHF LTYLRAYTYI LTLGKENIKM VGPYATLNAN YIKECLKDVY
KLPIDTICKH EFVFDGLMDK STGVTTMDVA KRLLDHGFHA PTIYFPLLFH EAMMIEPTEN
ESKETLDAFI EVMRKIADEA KNDPEIVKSA PQETPIKRVN DVEAAKHPIL TFKQLIDDNN
//
