ID D1W7N5_9BACT Unreviewed; 887 AA.
AC D1W7N5;
DT 09-FEB-2010, integrated into UniProtKB/TrEMBL.
DT 09-FEB-2010, sequence version 1.
DT 24-JAN-2024, entry version 71.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000256|HAMAP-Rule:MF_00096,
GN ECO:0000313|EMBL:EFA91450.1};
GN ORFNames=HMPREF0650_1930 {ECO:0000313|EMBL:EFA91450.1};
OS Hoylesella buccalis ATCC 35310.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Prevotellaceae;
OC Hoylesella.
OX NCBI_TaxID=679190 {ECO:0000313|EMBL:EFA91450.1, ECO:0000313|Proteomes:UP000005283};
RN [1] {ECO:0000313|EMBL:EFA91450.1, ECO:0000313|Proteomes:UP000005283}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35310 {ECO:0000313|EMBL:EFA91450.1,
RC ECO:0000313|Proteomes:UP000005283};
RA Durkin A.S., Madupu R., Torralba M., Methe B., Sutton G., Strausberg R.L.,
RA Nelson K.E.;
RT "Genome Sequence of Prevotella buccalis ATCC 35310.";
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000256|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|HAMAP-Rule:MF_00096,
CC ECO:0000256|RuleBase:RU003756}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFA91450.1}.
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DR EMBL; ADEG01000087; EFA91450.1; -; Genomic_DNA.
DR RefSeq; WP_004350291.1; NZ_ADEG01000087.1.
DR AlphaFoldDB; D1W7N5; -.
DR STRING; 679190.HMPREF0650_1930; -.
DR eggNOG; COG0249; Bacteria.
DR Proteomes; UP000005283; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00096}.
FT DOMAIN 706..722
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT BINDING 632..639
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00096"
SQ SEQUENCE 887 AA; 100371 MW; 025C13C251BF8948 CRC64;
MAQKDKGLTP MMKQFFSMKR QHPDALLLFR CGDFYETYGD DAIEGSRILG ITLTKRNNGG
NSGETAMAGF PHHALDTYLP KLIRAGKRVA ICDQLEDPKK KREELKGKKG LSATDKMVKR
GITELVTPGV AMGDNVLNYK ENNFLAAVHF GKAACGVSFL DISTGEFLTG EGTYDYVEKL
LGSFAPKEVL YDHNNKRDFD THFGTKYCVF ELEDWVFTEQ SARQRLLKHF GTKSLKGFGV
EQMKSGIVAS GAILQYLEIT QHTNIGHITS LARIEEERYV RLDKFTIHSL ELIDTMQEGG
RSLLNIIDKT ITPMGGRMLR RWMVFPLKDV TPIQQRLDVV DYFFKDPDFR QLVGEQFQRI
GDLERIISKV AVGRVSPREV VQLKNALQAL QPVKAACMKA SNESLRRIGE QLQLCEIIRD
RIEHEIQPDP PLLVNKGGVI ADGYDTELDE LRQISRNGKD YLIQIQEREV EQTGIASLKV
GYNNVFGYYL EVRNMYKDKV PENWVRKQTL AQAERYITEE LKAYEEKILG ADERIMMLED
KLFRELIVDM QPYIPQIQLD ANLIAHLDCL LGFAQVAEEN QYVRPQIDAT DVLDIKQGRH
PVIEMQLPLG ETYVPNDIYL DTEKQQVMMI TGPNMAGKSA LLRQTALIVL LAQIGCFVPA
ERAKIGLVDK IFTRVGASDN ISLGESTFMV EMTEAANILN NVTNRSLVLF DELGRGTSTY
DGISIAWAIV EYLHEQPRAR ARTLFATHYH ELNEMEKHFP RIHNYNVSVK EADGKVIFMR
KLERGGSEHS FGIHVAEIAG MPRSIVKRAN AILKQLEADN SEVGSVGKPS VKRLEESREG
MQLSFFQLDD PVLCQVRDEI LGLDINNLTP MEALNKLNEI KKIIGAE
//
