ID D1Y319_9BACT Unreviewed; 813 AA.
AC D1Y319;
DT 09-FEB-2010, integrated into UniProtKB/TrEMBL.
DT 09-FEB-2010, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=endopeptidase La {ECO:0000256|PROSITE-ProRule:PRU01122};
DE EC=3.4.21.53 {ECO:0000256|PROSITE-ProRule:PRU01122};
GN ORFNames=HMPREF7215_0309 {ECO:0000313|EMBL:EFB91218.1};
OS Pyramidobacter piscolens W5455.
OC Bacteria; Synergistota; Synergistia; Synergistales;
OC Dethiosulfovibrionaceae; Pyramidobacter.
OX NCBI_TaxID=352165 {ECO:0000313|EMBL:EFB91218.1, ECO:0000313|Proteomes:UP000006462};
RN [1] {ECO:0000313|EMBL:EFB91218.1, ECO:0000313|Proteomes:UP000006462}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=W5455 {ECO:0000313|EMBL:EFB91218.1,
RC ECO:0000313|Proteomes:UP000006462};
RA Shrivastava S., Madupu R., Durkin A.S., Torralba M., Methe B., Sutton G.G.,
RA Strausberg R.L., Nelson K.E.;
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of proteins in presence of ATP.; EC=3.4.21.53;
CC Evidence={ECO:0000256|PROSITE-ProRule:PRU01122};
CC -!- SIMILARITY: Belongs to the peptidase S16 family. {ECO:0000256|PROSITE-
CC ProRule:PRU01122}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFB91218.1}.
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DR EMBL; ADFP01000047; EFB91218.1; -; Genomic_DNA.
DR RefSeq; WP_009164282.1; NZ_ADFP01000047.1.
DR AlphaFoldDB; D1Y319; -.
DR STRING; 352165.HMPREF7215_0309; -.
DR eggNOG; COG1067; Bacteria.
DR OrthoDB; 9758568at2; -.
DR Proteomes; UP000006462; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004176; F:ATP-dependent peptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0030163; P:protein catabolic process; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR041699; AAA_32.
DR InterPro; IPR046844; Lon-like_helical.
DR InterPro; IPR008269; Lon_proteolytic.
DR InterPro; IPR027065; Lon_Prtase.
DR InterPro; IPR046843; LonB_AAA-LID.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR PANTHER; PTHR10046:SF46; ARCHAEAL LON PROTEASE; 1.
DR PANTHER; PTHR10046; ATP DEPENDENT LON PROTEASE FAMILY MEMBER; 1.
DR Pfam; PF13654; AAA_32; 1.
DR Pfam; PF05362; Lon_C; 1.
DR Pfam; PF20436; LonB_AAA-LID; 1.
DR Pfam; PF20437; LonC_helical; 1.
DR PRINTS; PR00830; ENDOLAPTASE.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS51786; LON_PROTEOLYTIC; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|PROSITE-ProRule:PRU01122};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU01122}; Serine protease {ECO:0000256|PROSITE-ProRule:PRU01122}.
FT DOMAIN 566..761
FT /note="Lon proteolytic"
FT /evidence="ECO:0000259|PROSITE:PS51786"
FT REGION 793..813
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 656
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01122"
FT ACT_SITE 699
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01122"
SQ SEQUENCE 813 AA; 91331 MW; 138266262203B5F7 CRC64;
MKIRARKLTA AQVRRKTDPK VLRCSSSAEL EGLTHFIGQE RAVKSIDFGL AVKSTGYNVF
IVGPQGSGRT SYALKSVREK AARLPAPNDW IYVNNFDEPA TPLAIDLPAG QAKKAEEDFD
KLIEELKSVI SGAFEKSSYE DAKAQEISSF QDQISKMMNH VREEAEKDGF LVKRTPQGFV
NIPLKIVKNG KGKKEFKELQ TDEFEALPRK EQKRLKSVSD ALTSKTLEVL RQIREKERAL
KAKLSDMEAE ICRTAIGPYL DEIREKYGQT KKFAQWIDSL ERQIVANYAL FIAAARDESG
EVDFTPYRIN VFVGNDPKGG APAVWETNPT FYNIAGKMEY ESRQGYYYTD FTRIVSGALH
RANGGYLILD AEELLRNFMS YDLLKRVLRS GLLTVENLSD QYSVMPITTP RPEAIPIKTK
VILVGSYYIY YLLREYDPDF PKFFKTVAEF DCEMPRTPEN EWDMARFVKT TAEQDGCLPF
NKKALAELIE WASRLADDQN KLSTQFNRLK EYVVESSAWA LSEGAKSVDR KHVLRAIQEK
RYRSSQTEEK IRAAFAEDII RIDTDGAVVG QINGLAVVSF AEVSFGHPAR ITANTFMGQE
GVINIEREIL MAGPIHNKGL LTLSSYLGRV YAQDMPLTLS ARLSFEQNYG GIDGDSASST
ELYCLLSSLA DVPIAQNIAV TGSVDQFGNI QPIGGVNEKI EGFFSYCLAR GLTGSQGVLI
PWQNERHLML NHDVVEAIRR KQFHIWSVKT IDEGIELLTG RPAGKRRADG TYPEDSIHGR
AMAKLKRWIE KSAALSRGQK GNAPSALSRE RKQ
//
