ID D1Y6G2_9BACT Unreviewed; 292 AA.
AC D1Y6G2;
DT 09-FEB-2010, integrated into UniProtKB/TrEMBL.
DT 09-FEB-2010, sequence version 1.
DT 24-JAN-2024, entry version 52.
DE SubName: Full=Phosphogluconate dehydrogenase (Decarboxylating), NAD binding domain protein {ECO:0000313|EMBL:EFB90100.1};
DE EC=1.1.1.60 {ECO:0000313|EMBL:EFB90100.1};
GN ORFNames=HMPREF7215_1821 {ECO:0000313|EMBL:EFB90100.1};
OS Pyramidobacter piscolens W5455.
OC Bacteria; Synergistota; Synergistia; Synergistales;
OC Dethiosulfovibrionaceae; Pyramidobacter.
OX NCBI_TaxID=352165 {ECO:0000313|EMBL:EFB90100.1, ECO:0000313|Proteomes:UP000006462};
RN [1] {ECO:0000313|EMBL:EFB90100.1, ECO:0000313|Proteomes:UP000006462}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=W5455 {ECO:0000313|EMBL:EFB90100.1,
RC ECO:0000313|Proteomes:UP000006462};
RA Shrivastava S., Madupu R., Durkin A.S., Torralba M., Methe B., Sutton G.G.,
RA Strausberg R.L., Nelson K.E.;
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the HIBADH-related family.
CC {ECO:0000256|ARBA:ARBA00009080}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFB90100.1}.
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DR EMBL; ADFP01000095; EFB90100.1; -; Genomic_DNA.
DR RefSeq; WP_009165443.1; NZ_ADFP01000095.1.
DR AlphaFoldDB; D1Y6G2; -.
DR STRING; 352165.HMPREF7215_1821; -.
DR eggNOG; COG2084; Bacteria.
DR OrthoDB; 9786703at2; -.
DR Proteomes; UP000006462; Unassembled WGS sequence.
DR GO; GO:0008679; F:2-hydroxy-3-oxopropionate reductase activity; IEA:UniProtKB-EC.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0016054; P:organic acid catabolic process; IEA:UniProt.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR002204; 3-OH-isobutyrate_DH-rel_CS.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR006115; 6PGDH_NADP-bd.
DR InterPro; IPR029154; HIBADH-like_NADP-bd.
DR InterPro; IPR015815; HIBADH-related.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43060; 3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED; 1.
DR PANTHER; PTHR43060:SF15; 3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED; 1.
DR Pfam; PF14833; NAD_binding_11; 1.
DR Pfam; PF03446; NAD_binding_2; 1.
DR PIRSF; PIRSF000103; HIBADH; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00895; 3_HYDROXYISOBUT_DH; 1.
PE 3: Inferred from homology;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Oxidoreductase {ECO:0000313|EMBL:EFB90100.1}.
FT DOMAIN 5..161
FT /note="6-phosphogluconate dehydrogenase NADP-binding"
FT /evidence="ECO:0000259|Pfam:PF03446"
FT DOMAIN 167..287
FT /note="3-hydroxyisobutyrate dehydrogenase-like NAD-binding"
FT /evidence="ECO:0000259|Pfam:PF14833"
FT ACT_SITE 173
FT /evidence="ECO:0000256|PIRSR:PIRSR000103-1"
SQ SEQUENCE 292 AA; 30807 MW; 6BF9FED263ADF48E CRC64;
MTLRKIGFVG LGVMGRAMAS NLMKAGFDLT VSNRSKTSAE TLLASGAAWA ESPADVMRAA
DAVITIVGYP RDVEQVYFGE RGLFAGFAPG KLLIDMTTSS PLLAAKIGAR ARELGCEALD
APVSGGDVGA RDAKLTIMAG GPETAFKLAE PLFAAMGKEW KLQGPWGAGQ HTKMANQIAI
ASNMMGVCEA LAYARAAGLD PRRVLESISG GAAGSFSMSN LAPRMLKGDF KPGFYVKHFI
KDMGIALDCA KEMKLDLPGL ALADKLYRRL AESGGENDGT QALYKLYASE RN
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