ID D1Y7C0_9BACT Unreviewed; 656 AA.
AC D1Y7C0;
DT 09-FEB-2010, integrated into UniProtKB/TrEMBL.
DT 09-FEB-2010, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE SubName: Full=DNA-directed DNA polymerase {ECO:0000313|EMBL:EFB89746.1};
DE EC=2.7.7.7 {ECO:0000313|EMBL:EFB89746.1};
GN Name=polA {ECO:0000313|EMBL:EFB89746.1};
GN ORFNames=HMPREF7215_2560 {ECO:0000313|EMBL:EFB89746.1};
OS Pyramidobacter piscolens W5455.
OC Bacteria; Synergistota; Synergistia; Synergistales;
OC Dethiosulfovibrionaceae; Pyramidobacter.
OX NCBI_TaxID=352165 {ECO:0000313|EMBL:EFB89746.1, ECO:0000313|Proteomes:UP000006462};
RN [1] {ECO:0000313|EMBL:EFB89746.1, ECO:0000313|Proteomes:UP000006462}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=W5455 {ECO:0000313|EMBL:EFB89746.1,
RC ECO:0000313|Proteomes:UP000006462};
RA Shrivastava S., Madupu R., Durkin A.S., Torralba M., Methe B., Sutton G.G.,
RA Strausberg R.L., Nelson K.E.;
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
CC -!- SIMILARITY: Belongs to the DNA polymerase type-A family.
CC {ECO:0000256|ARBA:ARBA00007705}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFB89746.1}.
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DR EMBL; ADFP01000121; EFB89746.1; -; Genomic_DNA.
DR RefSeq; WP_009165751.1; NZ_ADFP01000121.1.
DR AlphaFoldDB; D1Y7C0; -.
DR STRING; 352165.HMPREF7215_2560; -.
DR eggNOG; COG0749; Bacteria.
DR OrthoDB; 5465413at2; -.
DR Proteomes; UP000006462; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0006261; P:DNA-templated DNA replication; IEA:InterPro.
DR CDD; cd08643; DNA_pol_A_pol_I_B; 1.
DR Gene3D; 3.30.70.370; -; 2.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR001098; DNA-dir_DNA_pol_A_palm_dom.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR002298; DNA_polymerase_A.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR038720; YprB_RNase_H-like_dom.
DR PANTHER; PTHR10133; DNA POLYMERASE I; 1.
DR PANTHER; PTHR10133:SF62; DNA POLYMERASE THETA; 1.
DR Pfam; PF00476; DNA_pol_A; 1.
DR Pfam; PF13482; RNase_H_2; 1.
DR SMART; SM00482; POLAc; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
PE 3: Inferred from homology;
KW DNA-directed DNA polymerase {ECO:0000313|EMBL:EFB89746.1};
KW Nucleotidyltransferase {ECO:0000313|EMBL:EFB89746.1};
KW Transferase {ECO:0000313|EMBL:EFB89746.1}.
FT DOMAIN 372..617
FT /note="DNA-directed DNA polymerase family A palm"
FT /evidence="ECO:0000259|SMART:SM00482"
SQ SEQUENCE 656 AA; 73920 MW; 0BF7C82636B742A5 CRC64;
MLIFDIETDG LLDATTKVHC LTIYDTETDE SRLYSSRGDY PQIPVGVERL AAADCVCGHN
VLAFDIPALT KVYPSFAPKG EVVDTLTISR LIWTNLADLD FTEIRRAKTP AQPMFFFPKK
LVGSHSLKAW GYRLGVLKGE FGETTDWQEW SEEMCAYNRQ DVVVTRALWE RIQEQDYSQT
AIDLEHQFQK IILQQEQNGF PFNQEKAVLY YSQLAKRREE LTQELQRIFP PEDKGDWFVP
KVNNAKRGYV KGERVWRARI TAFNPGSRKD IAERLRETRG WEPQEYTERG TPKVDEEVLS
ALDWPEAKAL SEYFLVQKRI GQLAEGNNAW LKLVGRDGRI HGHVITNGAV TGRCTHVSPN
MAQVPAVGVP WGAEFRSLFY APPGWSVLGA DASGLELRCL AHFMARYDGG AYARKILEGD
IHWANAQALG LVAEGEKKDP ENPYHMWARN KVAKRFIYAL NYGAGDHKLG ELVELTDDQA
KALLAAAPKS KIDQTSARLA KQFQYKTITF KDIAQSLKGA ELRATFMKNL PALASLIEDV
KRVAKKRGYL IGLDKRRLNV RSIHSAFNTL LQSAGAIAVK KATCVLWDDL TTAGLADKVQ
QVAHVHDEYQ LLVKEGEEEH VGQIATAAFG KAGLFFEFRI PLAGEFKFGR NWAETH
//
