ID D1YXV9_METPS Unreviewed; 212 AA.
AC D1YXV9;
DT 09-FEB-2010, integrated into UniProtKB/TrEMBL.
DT 09-FEB-2010, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE SubName: Full=Thymidylate synthase {ECO:0000313|EMBL:BAI61281.1};
GN Name=thyA {ECO:0000313|EMBL:BAI61281.1};
GN OrderedLocusNames=MCP_1209 {ECO:0000313|EMBL:BAI61281.1};
OS Methanocella paludicola (strain DSM 17711 / JCM 13418 / NBRC 101707 /
OS SANAE).
OC Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC Methanocellales; Methanocellaceae; Methanocella.
OX NCBI_TaxID=304371 {ECO:0000313|EMBL:BAI61281.1, ECO:0000313|Proteomes:UP000001882};
RN [1] {ECO:0000313|Proteomes:UP000001882}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 17711 / JCM 13418 / NBRC 101707 / SANAE
RC {ECO:0000313|Proteomes:UP000001882};
RX PubMed=21829548; DOI=10.1371/journal.pone.0022898;
RA Sakai S., Takaki Y., Shimamura S., Sekine M., Tajima T., Kosugi H.,
RA Ichikawa N., Tasumi E., Hiraki A.T., Shimizu A., Kato Y., Nishiko R.,
RA Mori K., Fujita N., Imachi H., Takai K.;
RT "Genome sequence of a mesophilic hydrogenotrophic methanogen Methanocella
RT paludicola, the first cultivated representative of the order
RT Methanocellales.";
RL PLoS ONE 6:E22898-E22898(2011).
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DR EMBL; AP011532; BAI61281.1; -; Genomic_DNA.
DR AlphaFoldDB; D1YXV9; -.
DR STRING; 304371.MCP_1209; -.
DR KEGG; mpd:MCP_1209; -.
DR eggNOG; arCOG03214; Archaea.
DR InParanoid; D1YXV9; -.
DR OrthoDB; 50118at2157; -.
DR Proteomes; UP000001882; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0004799; F:thymidylate synthase activity; IEA:InterPro.
DR GO; GO:0006235; P:dTTP biosynthetic process; IEA:InterPro.
DR Gene3D; 3.30.572.10; Thymidylate synthase/dCMP hydroxymethylase domain; 1.
DR InterPro; IPR023451; Thymidate_synth/dCMP_Mease_dom.
DR InterPro; IPR036926; Thymidate_synth/dCMP_Mease_sf.
DR InterPro; IPR014620; Thymidylate_synthase_arc.
DR Pfam; PF00303; Thymidylat_synt; 1.
DR PIRSF; PIRSF036752; TSase_MJ051; 1.
DR SUPFAM; SSF55831; Thymidylate synthase/dCMP hydroxymethylase; 1.
PE 4: Predicted;
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 66..211
FT /note="Thymidylate synthase/dCMP hydroxymethylase"
FT /evidence="ECO:0000259|Pfam:PF00303"
SQ SEQUENCE 212 AA; 25406 MW; F4F39E7B6954CCAF CRC64;
MIAGTFDTLS EAWYWAIKEI YTNGQLVETE YGIKAKCING MLLEVRNPVQ VWHKKDPFCT
KERVEFYKKQ FKRESAGRHG FEYTYIDRLV NYEGFDQLKW MGEQLQNKRY ESKRIQAITW
MPKIDCMKKE DQPCFQRIWV FPHKNNKLDV HIHYRSWDMF KAFEANLMAF QELVKDELIG
PTDFMLGTLR CFGDNVHIYE DDFQAAEEVL KP
//
