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Database: UniProt
Entry: D1Z1W7_METPS
LinkDB: D1Z1W7_METPS
Original site: D1Z1W7_METPS 
ID   D1Z1W7_METPS            Unreviewed;       336 AA.
AC   D1Z1W7;
DT   09-FEB-2010, integrated into UniProtKB/TrEMBL.
DT   09-FEB-2010, sequence version 1.
DT   28-MAR-2018, entry version 50.
DE   RecName: Full=Transcription initiation factor IIB {ECO:0000256|HAMAP-Rule:MF_00383};
DE            Short=TFIIB {ECO:0000256|HAMAP-Rule:MF_00383};
GN   Name=tfb {ECO:0000256|HAMAP-Rule:MF_00383,
GN   ECO:0000313|EMBL:BAI62689.1};
GN   OrderedLocusNames=MCP_2617 {ECO:0000313|EMBL:BAI62689.1};
OS   Methanocella paludicola (strain DSM 17711 / JCM 13418 / NBRC 101707 /
OS   SANAE).
OC   Archaea; Euryarchaeota; Methanomicrobia; Methanocellales;
OC   Methanocellaceae; Methanocella.
OX   NCBI_TaxID=304371 {ECO:0000313|EMBL:BAI62689.1, ECO:0000313|Proteomes:UP000001882};
RN   [1] {ECO:0000313|Proteomes:UP000001882}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 17711 / JCM 13418 / NBRC 101707 / SANAE
RC   {ECO:0000313|Proteomes:UP000001882};
RX   PubMed=21829548; DOI=10.1371/journal.pone.0022898;
RA   Sakai S., Takaki Y., Shimamura S., Sekine M., Tajima T., Kosugi H.,
RA   Ichikawa N., Tasumi E., Hiraki A.T., Shimizu A., Kato Y., Nishiko R.,
RA   Mori K., Fujita N., Imachi H., Takai K.;
RT   "Genome sequence of a mesophilic hydrogenotrophic methanogen
RT   Methanocella paludicola, the first cultivated representative of the
RT   order Methanocellales.";
RL   PLoS ONE 6:E22898-E22898(2011).
CC   -!- FUNCTION: Stabilizes TBP binding to an archaeal box-A promoter.
CC       Also responsible for recruiting RNA polymerase II to the pre-
CC       initiation complex (DNA-TBP-TFIIB). {ECO:0000256|HAMAP-
CC       Rule:MF_00383}.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000256|HAMAP-
CC         Rule:MF_00383};
CC       Note=Binds 1 zinc ion per subunit. {ECO:0000256|HAMAP-
CC       Rule:MF_00383};
CC   -!- SIMILARITY: Belongs to the TFIIB family. {ECO:0000256|HAMAP-
CC       Rule:MF_00383}.
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DR   EMBL; AP011532; BAI62689.1; -; Genomic_DNA.
DR   STRING; 304371.MCP_2617; -.
DR   EnsemblBacteria; BAI62689; BAI62689; MCP_2617.
DR   KEGG; mpd:MCP_2617; -.
DR   PATRIC; fig|304371.9.peg.2674; -.
DR   eggNOG; arCOG01981; Archaea.
DR   eggNOG; COG1405; LUCA.
DR   HOGENOM; HOG000108633; -.
DR   KO; K03124; -.
DR   OMA; WRAFDHD; -.
DR   OrthoDB; POG093Z07LX; -.
DR   Proteomes; UP000001882; Chromosome.
DR   GO; GO:0003700; F:DNA binding transcription factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0017025; F:TBP-class protein binding; IEA:InterPro.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0070897; P:DNA-templated transcriptional preinitiation complex assembly; IEA:InterPro.
DR   CDD; cd00043; CYCLIN; 2.
DR   HAMAP; MF_00383; TF2B_arch; 1.
DR   InterPro; IPR013763; Cyclin-like.
DR   InterPro; IPR036915; Cyclin-like_sf.
DR   InterPro; IPR000812; TFIIB.
DR   InterPro; IPR023484; TFIIB_arc.
DR   InterPro; IPR023486; TFIIB_CS.
DR   InterPro; IPR013150; TFIIB_cyclin.
DR   InterPro; IPR013137; Znf_TFIIB.
DR   PANTHER; PTHR11618; PTHR11618; 1.
DR   Pfam; PF08271; TF_Zn_Ribbon; 1.
DR   Pfam; PF00382; TFIIB; 2.
DR   PRINTS; PR00685; TIFACTORIIB.
DR   SMART; SM00385; CYCLIN; 2.
DR   SUPFAM; SSF47954; SSF47954; 2.
DR   PROSITE; PS00782; TFIIB; 2.
DR   PROSITE; PS51134; ZF_TFIIB; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001882};
KW   Initiation factor {ECO:0000313|EMBL:BAI62689.1};
KW   Metal-binding {ECO:0000256|HAMAP-Rule:MF_00383, ECO:0000256|PROSITE-
KW   ProRule:PRU00469};
KW   Protein biosynthesis {ECO:0000313|EMBL:BAI62689.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001882};
KW   Repeat {ECO:0000256|HAMAP-Rule:MF_00383};
KW   Transcription {ECO:0000256|HAMAP-Rule:MF_00383};
KW   Transcription regulation {ECO:0000256|HAMAP-Rule:MF_00383};
KW   Zinc {ECO:0000256|HAMAP-Rule:MF_00383, ECO:0000256|PROSITE-
KW   ProRule:PRU00469};
KW   Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00469}.
FT   DOMAIN       35     67       TFIIB-type. {ECO:0000259|PROSITE:
FT                                PS51134}.
FT   REPEAT      153    236       1. {ECO:0000256|HAMAP-Rule:MF_00383}.
FT   REPEAT      247    328       2. {ECO:0000256|HAMAP-Rule:MF_00383}.
FT   ZN_FING      35     67       TFIIB-type. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00469}.
FT   METAL        40     40       Zinc. {ECO:0000256|HAMAP-Rule:MF_00383}.
FT   METAL        43     43       Zinc. {ECO:0000256|HAMAP-Rule:MF_00383}.
FT   METAL        59     59       Zinc. {ECO:0000256|HAMAP-Rule:MF_00383}.
FT   METAL        62     62       Zinc. {ECO:0000256|HAMAP-Rule:MF_00383}.
SQ   SEQUENCE   336 AA;  38145 MW;  24A0DF03809125C0 CRC64;
     MAEIEKIREI EKKEIPKEKT LERVKKEGEK AEGEERIVEC PECGSRQLVH DYERAELVCN
     ECGLVVDEDF IDMGPEWRAF DHDQRMKRSR VGAPMTFTIH DKGLSTMIDW RNRDSYGKSI
     SSKNRAQLYR LRKWQRRIRV SNATERNLAF ALSELDRMAS ALGLPRNIRE TSAVVYRKAV
     TKNLIRGRSI EGVAAAALYA ACRQNGVPRT LDEIAEVSRV SRKEIGRTYR FISRELGLKL
     MPTSPIDYVP RFCSGLSLKG EVQSRAVEIL RQAAEKELTS GRGPTGVAAA AIYISSILCG
     ERRTQREVAN VAGVTEVTIR NRYKELAEEL DIEIIL
//
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