ID D2A3G8_TRICA Unreviewed; 1363 AA.
AC D2A3G8;
DT 09-FEB-2010, integrated into UniProtKB/TrEMBL.
DT 09-FEB-2010, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=WD repeat-containing protein 19-like Protein {ECO:0000313|EMBL:EFA01913.1};
GN Name=AUGUSTUS-3.0.2_07523 {ECO:0000313|EMBL:EFA01913.1};
GN ORFNames=TcasGA2_TC007523 {ECO:0000313|EMBL:EFA01913.1};
OS Tribolium castaneum (Red flour beetle).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia;
OC Tenebrionidae; Tenebrionidae incertae sedis; Tribolium.
OX NCBI_TaxID=7070 {ECO:0000313|EMBL:EFA01913.1, ECO:0000313|Proteomes:UP000007266};
RN [1] {ECO:0000313|EMBL:EFA01913.1, ECO:0000313|Proteomes:UP000007266}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Georgia GA2 {ECO:0000313|EMBL:EFA01913.1,
RC ECO:0000313|Proteomes:UP000007266};
RX PubMed=18362917; DOI=10.1038/nature06784;
RG Tribolium Genome Sequencing Consortium;
RA Richards S., Gibbs R.A., Weinstock G.M., Brown S.J., Denell R.,
RA Beeman R.W., Gibbs R., Beeman R.W., Brown S.J., Bucher G., Friedrich M.,
RA Grimmelikhuijzen C.J., Klingler M., Lorenzen M., Richards S., Roth S.,
RA Schroder R., Tautz D., Zdobnov E.M., Muzny D., Gibbs R.A., Weinstock G.M.,
RA Attaway T., Bell S., Buhay C.J., Chandrabose M.N., Chavez D.,
RA Clerk-Blankenburg K.P., Cree A., Dao M., Davis C., Chacko J., Dinh H.,
RA Dugan-Rocha S., Fowler G., Garner T.T., Garnes J., Gnirke A., Hawes A.,
RA Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N., Joshi V.,
RA Khan Z.M., Jackson L., Kovar C., Kowis A., Lee S., Lewis L.R., Margolis J.,
RA Morgan M., Nazareth L.V., Nguyen N., Okwuonu G., Parker D., Richards S.,
RA Ruiz S.J., Santibanez J., Savard J., Scherer S.E., Schneider B.,
RA Sodergren E., Tautz D., Vattahil S., Villasana D., White C.S., Wright R.,
RA Park Y., Beeman R.W., Lord J., Oppert B., Lorenzen M., Brown S., Wang L.,
RA Savard J., Tautz D., Richards S., Weinstock G., Gibbs R.A., Liu Y.,
RA Worley K., Weinstock G., Elsik C.G., Reese J.T., Elhaik E., Landan G.,
RA Graur D., Arensburger P., Atkinson P., Beeman R.W., Beidler J., Brown S.J.,
RA Demuth J.P., Drury D.W., Du Y.Z., Fujiwara H., Lorenzen M., Maselli V.,
RA Osanai M., Park Y., Robertson H.M., Tu Z., Wang J.J., Wang S., Richards S.,
RA Song H., Zhang L., Sodergren E., Werner D., Stanke M., Morgenstern B.,
RA Solovyev V., Kosarev P., Brown G., Chen H.C., Ermolaeva O., Hlavina W.,
RA Kapustin Y., Kiryutin B., Kitts P., Maglott D., Pruitt K., Sapojnikov V.,
RA Souvorov A., Mackey A.J., Waterhouse R.M., Wyder S., Zdobnov E.M.,
RA Zdobnov E.M., Wyder S., Kriventseva E.V., Kadowaki T., Bork P., Aranda M.,
RA Bao R., Beermann A., Berns N., Bolognesi R., Bonneton F., Bopp D.,
RA Brown S.J., Bucher G., Butts T., Chaumot A., Denell R.E., Ferrier D.E.,
RA Friedrich M., Gordon C.M., Jindra M., Klingler M., Lan Q., Lattorff H.M.,
RA Laudet V., von Levetsow C., Liu Z., Lutz R., Lynch J.A., da Fonseca R.N.,
RA Posnien N., Reuter R., Roth S., Savard J., Schinko J.B., Schmitt C.,
RA Schoppmeier M., Schroder R., Shippy T.D., Simonnet F., Marques-Souza H.,
RA Tautz D., Tomoyasu Y., Trauner J., Van der Zee M., Vervoort M.,
RA Wittkopp N., Wimmer E.A., Yang X., Jones A.K., Sattelle D.B., Ebert P.R.,
RA Nelson D., Scott J.G., Beeman R.W., Muthukrishnan S., Kramer K.J.,
RA Arakane Y., Beeman R.W., Zhu Q., Hogenkamp D., Dixit R., Oppert B.,
RA Jiang H., Zou Z., Marshall J., Elpidina E., Vinokurov K., Oppert C.,
RA Zou Z., Evans J., Lu Z., Zhao P., Sumathipala N., Altincicek B.,
RA Vilcinskas A., Williams M., Hultmark D., Hetru C., Jiang H.,
RA Grimmelikhuijzen C.J., Hauser F., Cazzamali G., Williamson M., Park Y.,
RA Li B., Tanaka Y., Predel R., Neupert S., Schachtner J., Verleyen P.,
RA Raible F., Bork P., Friedrich M., Walden K.K., Robertson H.M., Angeli S.,
RA Foret S., Bucher G., Schuetz S., Maleszka R., Wimmer E.A., Beeman R.W.,
RA Lorenzen M., Tomoyasu Y., Miller S.C., Grossmann D., Bucher G.;
RT "The genome of the model beetle and pest Tribolium castaneum.";
RL Nature 452:949-955(2008).
RN [2] {ECO:0000313|EMBL:EFA01913.1, ECO:0000313|Proteomes:UP000007266}
RP GENOME REANNOTATION.
RC STRAIN=Georgia GA2 {ECO:0000313|EMBL:EFA01913.1,
RC ECO:0000313|Proteomes:UP000007266};
RX PubMed=19820115; DOI=10.1093/nar/gkp807;
RA Kim H.S., Murphy T., Xia J., Caragea D., Park Y., Beeman R.W.,
RA Lorenzen M.D., Butcher S., Manak J.R., Brown S.J.;
RT "BeetleBase in 2010: revisions to provide comprehensive genomic information
RT for Tribolium castaneum.";
RL Nucleic Acids Res. 38:D437-D442(2010).
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DR EMBL; KQ971338; EFA01913.1; -; Genomic_DNA.
DR RefSeq; XP_015834561.1; XM_015979075.1.
DR STRING; 7070.D2A3G8; -.
DR EnsemblMetazoa; TC007523_001; TC007523_001; TC007523.
DR GeneID; 664270; -.
DR eggNOG; KOG2247; Eukaryota.
DR HOGENOM; CLU_003002_2_0_1; -.
DR InParanoid; D2A3G8; -.
DR OMA; CTGFGWD; -.
DR OrthoDB; 5476164at2759; -.
DR PhylomeDB; D2A3G8; -.
DR Proteomes; UP000007266; Linkage group 4.
DR GO; GO:0005929; C:cilium; IBA:GO_Central.
DR GO; GO:0030991; C:intraciliary transport particle A; IBA:GO_Central.
DR GO; GO:0060271; P:cilium assembly; IBA:GO_Central.
DR GO; GO:0035721; P:intraciliary retrograde transport; IBA:GO_Central.
DR Gene3D; 1.25.40.470; -; 2.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 3.
DR InterPro; IPR024977; Apc4-like_WD40_dom.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR InterPro; IPR040379; WDR19/dyf-2.
DR InterPro; IPR039468; WDR19_WD40_rpt.
DR PANTHER; PTHR14920; OSMOTIC AVOIDANCE ABNORMAL PROTEIN 1/WD REPEAT MEMBRANE PROTEIN; 1.
DR PANTHER; PTHR14920:SF0; WD REPEAT-CONTAINING PROTEIN 19 ISOFORM X2; 1.
DR Pfam; PF12894; ANAPC4_WD40; 1.
DR Pfam; PF15911; WD40_3; 1.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF82171; DPP6 N-terminal domain-like; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000007266}.
FT DOMAIN 64..150
FT /note="Anaphase-promoting complex subunit 4-like WD40"
FT /evidence="ECO:0000259|Pfam:PF12894"
SQ SEQUENCE 1363 AA; 153682 MW; 3B6DF6E861B05FC8 CRC64;
MGSEKLLFRL EQPHGTGDIY TTWQNGSGMY LATTGIDCMV NIFDRYGQIQ DRIRLPSLCT
GFGWDSDGDL LAVICQSPQL TLWDANTQKK IQIDVRLKDQ MSCVIWAKTA PMLAVGTVKG
NISIYNHNTS KRTPVIGKHA KKITCGAWNT ENLLALGSED KTISISNVDG DTLRVINLRA
EPSEINFSEM KLDERMGGEN TVSVIVGKRT LYLYNLLDPD NPIELAFQQH YGSIVTYKWF
GDGYILIGFN AGYFIAISTH IKEVGQELFQ VRNHKNTLTD ITINDKIGKA ASCGDNNVKI
HDLSNLQETS SVLTLSQEAG LERISWSVDG QLFSVCTRGG SLNVYLSHVP LLTSVSTPRI
AILSSLTEIS LYNYSSEKTK YKPIPITLET EPSFIAVGPY HIAAGLNNRV WFYDLTRPQP
GVDDAPLMLK DRQYLGGVTS IKLNPEYASV LFEGKLQLHM IEQPEVCHED RETIMFPNAN
SPNLFITCHF LTTDFLIYGT DMGNIVYFHV EEWALAHEYK HEVGIVNVFA DPAGTRLVFV
DIKGQGYVYN AVINEVVLIP NLPNKVLGVT WDSNINDRNI FIVYDQHDIF TYVYVRYSIN
GSSVQKVGQT SLVTKQIPLL MYSGEVISAT PGGQITQLIL NTHDSPQIGV NEHDQTIQET
NFNKQIALYR FSAAWTTCET LKSEELWRKL AVEAMKHLEI DLAIRVFKLL DDVSMVWSLE
SIAGVEDHKL LCGYVAMFLN DFDLAQDWFM GSSYPVAALE MRRDLLQWDQ ALQLAKKMAP
EQIALISREY AQQLEFTGNY SEAHIHYEKG LQEDLSPEHT FICKAGIART ALHCNNTRHG
ISIALELDNK QLLKECAEIL EKNKHLNEAA NLFEKCQNYD RAALNYIKLR NWQKIGELLP
KITSNKIHLQ YAVAKENEGK YEEAVRAYYT AKDYDSVIRL QLEHLNNPEI AVELVQETKS
TEGAKLVAKF FQKLNDYTSA IKFLVMSKCN EEAFDLARKH GKMQLYGEIL LNTLAPDELR
PHDFNSIATH FENERNNLLA GIYWFHAKEY AKAMKHLLKA AKSNSKENEA ITAAIDVVAS
SKNEALSSQL IEFLLGESDG LPKDPKYLFR LYMARKQYKE ASKSALIIAN EEQINGNYRN
AHDVLFAMYQ ELKQNGIKVP NEMQANLMLL HSYILVRLHV KRGDHLKGAR MLIRVANNIS
KFPSHKVPIL TSTVIECHRA GLKHAAFKYA TMLMNPEYRK NVDAKYAKKI EAVVRKPPKS
GKAGDGGGDP VEPLTPCPYC ENLLPETETN CNGCKNNIPF CVVTGRHIVT TDLTACPECD
FPALRSQFIE ILDSEDSCPM CSEKVDSRRL PKIDDPKPYL NVE
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