ID D2D336_GOSHI Unreviewed; 667 AA.
AC D2D336;
DT 09-FEB-2010, integrated into UniProtKB/TrEMBL.
DT 09-FEB-2010, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=Rhamnose synthase {ECO:0000313|EMBL:ACJ11756.1};
DE SubName: Full=Trifunctional UDP-glucose 4,6-dehydratase/UDP-4-keto-6-deoxy-D-glucose 3,5-epimerase/UDP-4-keto-L-rhamnose-reductase RHM1-like {ECO:0000313|RefSeq:XP_016714730.1, ECO:0000313|RefSeq:XP_016714731.1};
GN Name=LOC107928094 {ECO:0000313|RefSeq:XP_016714730.1,
GN ECO:0000313|RefSeq:XP_016714731.1};
OS Gossypium hirsutum (Upland cotton) (Gossypium mexicanum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Malvales; Malvaceae; Malvoideae; Gossypium.
OX NCBI_TaxID=3635 {ECO:0000313|EMBL:ACJ11756.1};
RN [1] {ECO:0000313|EMBL:ACJ11756.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Ovule {ECO:0000313|EMBL:ACJ11756.1};
RA Pang C., Pang Y., Wang H., Jin X., Qin Y., Yu S., Zhu Y.;
RT "A Cross-Talk between Pectin and Cellulose Biosyntheses that Are Oppositely
RT Regulated by Ethylene Determines Cotton Fiber Cell Length.";
RL Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000189702}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. TM-1 {ECO:0000313|Proteomes:UP000189702};
RX PubMed=25893780; DOI=10.1038/nbt.3208;
RA Li F., Fan G., Lu C., Xiao G., Zou C., Kohel R.J., Ma Z., Shang H., Ma X.,
RA Wu J., Liang X., Huang G., Percy R.G., Liu K., Yang W., Chen W., Du X.,
RA Shi C., Yuan Y., Ye W., Liu X., Zhang X., Liu W., Wei H., Wei S., Huang G.,
RA Zhang X., Zhu S., Zhang H., Sun F., Wang X., Liang J., Wang J., He Q.,
RA Huang L., Wang J., Cui J., Song G., Wang K., Xu X., Yu J.Z., Zhu Y., Yu S.;
RT "Genome sequence of cultivated Upland cotton (Gossypium hirsutum TM-1)
RT provides insights into genome evolution.";
RL Nat. Biotechnol. 33:524-530(2015).
RN [3] {ECO:0000313|RefSeq:XP_016714730.1, ECO:0000313|RefSeq:XP_016714731.1}
RP IDENTIFICATION.
RC TISSUE=Leaf {ECO:0000313|RefSeq:XP_016714730.1,
RC ECO:0000313|RefSeq:XP_016714731.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=NAD(+); Xref=ChEBI:CHEBI:57540;
CC Evidence={ECO:0000256|ARBA:ARBA00001911};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; FJ415210; ACJ11756.1; -; mRNA.
DR RefSeq; NP_001314210.1; NM_001327281.1.
DR RefSeq; XP_016714730.1; XM_016859241.1.
DR RefSeq; XP_016714731.1; XM_016859242.1.
DR STRING; 3635.D2D336; -.
DR PaxDb; 3635-D2D336; -.
DR GeneID; 107928094; -.
DR KEGG; ghi:107928094; -.
DR OMA; NTLQCRI; -.
DR OrthoDB; 5486426at2759; -.
DR Proteomes; UP000189702; Unplaced.
DR GO; GO:0008460; F:dTDP-glucose 4,6-dehydratase activity; IEA:InterPro.
DR GO; GO:0050377; F:UDP-glucose 4,6-dehydratase activity; IBA:GO_Central.
DR GO; GO:0010280; F:UDP-L-rhamnose synthase activity; IBA:GO_Central.
DR GO; GO:0010315; P:auxin export across the plasma membrane; IBA:GO_Central.
DR GO; GO:0051555; P:flavonol biosynthetic process; IBA:GO_Central.
DR GO; GO:0010253; P:UDP-rhamnose biosynthetic process; IBA:GO_Central.
DR CDD; cd05246; dTDP_GD_SDR_e; 1.
DR CDD; cd05254; dTDP_HR_like_SDR_e; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR Gene3D; 3.90.25.10; UDP-galactose 4-epimerase, domain 1; 1.
DR InterPro; IPR005888; dTDP_Gluc_deHydtase.
DR InterPro; IPR016040; NAD(P)-bd_dom.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR029903; RmlD-like-bd.
DR NCBIfam; TIGR01181; dTDP_gluc_dehyt; 1.
DR PANTHER; PTHR43000:SF7; DTDP-D-GLUCOSE 4,6-DEHYDRATASE; 1.
DR PANTHER; PTHR43000; DTDP-D-GLUCOSE 4,6-DEHYDRATASE-RELATED; 1.
DR Pfam; PF16363; GDP_Man_Dehyd; 1.
DR Pfam; PF04321; RmlD_sub_bind; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
PE 2: Evidence at transcript level;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Reference proteome {ECO:0000313|Proteomes:UP000189702}.
FT DOMAIN 10..315
FT /note="NAD(P)-binding"
FT /evidence="ECO:0000259|Pfam:PF16363"
FT DOMAIN 384..559
FT /note="RmlD-like substrate binding"
FT /evidence="ECO:0000259|Pfam:PF04321"
SQ SEQUENCE 667 AA; 75185 MW; 6CC109724F0EA7E6 CRC64;
MSSYTPKNIL ITGAAGFIAS HVANRLIRNY PDYKIVVLDK LDYCSNLKNL LPSKSSPNFK
FVKGDIGSAD LVNYLLITES IDTIMHFAAQ THVDNSFGNS FEFTKNNIYG THVLLEACKV
TGQIRRFIHV STDEVYGETD EDAVVGNHEA SQLLPTNPYS ATKAGAEMLV MAYGRSYGLP
VITTRGNNVY GPNQFPEKLI PKFILLAMRG KTLPIHGDGS NVRSYLYCED VAEAFEVILH
KGEVGHVYNI GTKKERRVID VAKDICKLFS MDPETSIKFV ENRPFNDQRY FLDDEKLKNL
GWSEQTVWEE GLKKTIEWYT QNPEWWGDVS GALLPHPRML MMPGGRHFDS EEGKGTSFAS
GPNQTRMVVP TFKTSSSTQK PALKFLIYGR TGWIGGLLGQ LCEKQGIPFE YGRGRLEDRS
SLMADIQNIK PTHVFNAAGV TGRPNVDWCE SHKTETIRTN VAGTLTLADV CREHGLLMMN
FATGCIFEYD AGHPEGSGIG YKEEDKPNFT GSFYSKTKAM VEELLKEYDN VCTLRVRMPI
SSDLNNPRNF ITKIARYNKV VNIPNSMTIL DELLPISIEM AKRNLNGIWN FTNPGVVSHN
EILEMYKAYI DPKFQWVNFT LEEQAKVIVA PRSNNEMDAS KLKNEFPDLL PIKESLIKYV
FEPNKRT
//
