ID D2GVB4_AILME Unreviewed; 817 AA.
AC D2GVB4;
DT 09-FEB-2010, integrated into UniProtKB/TrEMBL.
DT 09-FEB-2010, sequence version 1.
DT 27-MAR-2024, entry version 74.
DE SubName: Full=Tax1 binding protein 1 {ECO:0000313|Ensembl:ENSAMEP00000006157.1};
DE Flags: Fragment;
GN Name=TAX1BP1 {ECO:0000313|Ensembl:ENSAMEP00000006157.1};
GN ORFNames=PANDA_000648 {ECO:0000313|EMBL:EFB25120.1};
OS Ailuropoda melanoleuca (Giant panda).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX NCBI_TaxID=9646 {ECO:0000313|EMBL:EFB25120.1};
RN [1] {ECO:0000313|EMBL:EFB25120.1, ECO:0000313|Proteomes:UP000008912}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20010809; DOI=10.1038/nature08696;
RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA Wang J.;
RT "The sequence and de novo assembly of the giant panda genome.";
RL Nature 463:311-317(2010).
RN [2] {ECO:0000313|Ensembl:ENSAMEP00000006157.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, autophagosome
CC {ECO:0000256|ARBA:ARBA00004419}. Preautophagosomal structure
CC {ECO:0000256|ARBA:ARBA00004329}.
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DR EMBL; GL192349; EFB25120.1; -; Genomic_DNA.
DR RefSeq; XP_002912899.1; XM_002912853.3.
DR STRING; 9646.ENSAMEP00000006157; -.
DR Ensembl; ENSAMET00000006411.2; ENSAMEP00000006157.1; ENSAMEG00000005802.2.
DR GeneID; 100468642; -.
DR KEGG; aml:100468642; -.
DR CTD; 8887; -.
DR eggNOG; ENOG502QQ1D; Eukaryota.
DR GeneTree; ENSGT00950000183025; -.
DR HOGENOM; CLU_021315_1_0_1; -.
DR OMA; MEDQYLV; -.
DR OrthoDB; 3062393at2759; -.
DR TreeFam; TF329501; -.
DR Proteomes; UP000008912; Unassembled WGS sequence.
DR GO; GO:0005776; C:autophagosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005739; C:mitochondrion; IEA:Ensembl.
DR GO; GO:0000407; C:phagophore assembly site; IEA:UniProtKB-SubCell.
DR GO; GO:0019900; F:kinase binding; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0030674; F:protein-macromolecule adaptor activity; IEA:Ensembl.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0039532; P:negative regulation of cytoplasmic pattern recognition receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0034144; P:negative regulation of toll-like receptor 4 signaling pathway; IEA:Ensembl.
DR GO; GO:1905161; P:protein localization to phagocytic vesicle; IEA:Ensembl.
DR CDD; cd21969; Zn-C2H2_TAX1BP1_rpt1; 1.
DR CDD; cd21970; Zn-C2H2_TAX1BP1_rpt2; 1.
DR Gene3D; 2.60.40.2840; -; 1.
DR Gene3D; 6.20.250.40; -; 1.
DR InterPro; IPR012852; CALCOCO1-like.
DR InterPro; IPR041641; CALCOCO1/2_Zn_UBZ1.
DR InterPro; IPR041611; SKICH.
DR InterPro; IPR000626; Ubiquitin-like_dom.
DR PANTHER; PTHR31915; SKICH DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR31915:SF8; TAX1-BINDING PROTEIN 1; 1.
DR Pfam; PF07888; CALCOCO1; 1.
DR Pfam; PF17751; SKICH; 1.
DR Pfam; PF18112; Zn-C2H2_12; 2.
DR PROSITE; PS50053; UBIQUITIN_2; 1.
DR PROSITE; PS51905; ZF_UBZ1; 2.
PE 4: Predicted;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000008912};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU01253}.
FT DOMAIN 325..396
FT /note="Ubiquitin-like"
FT /evidence="ECO:0000259|PROSITE:PS50053"
FT DOMAIN 755..781
FT /note="UBZ1-type"
FT /evidence="ECO:0000259|PROSITE:PS51905"
FT DOMAIN 782..808
FT /note="UBZ1-type"
FT /evidence="ECO:0000259|PROSITE:PS51905"
FT REGION 467..515
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 670..692
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 706..742
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 154..307
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 591..628
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 467..500
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 817
FT /evidence="ECO:0000313|EMBL:EFB25120.1"
SQ SEQUENCE 817 AA; 93928 MW; 34E261B6FA00D6BC CRC64;
MTSFQEVPLQ TSNFAHVIFQ NVAKSYLPNA HLECHYTLTP YIHPHPKDWV GIFKVGWSTA
RDYYTFLWSP MPEHYIEGST VNCVLAFQGY YLPNDDGEFY QFCYVTHKGE IRGASTPFQF
RASSPVEELL TMEDEGNSDM LVVTTKAGLL ELKIEKTMKE KEELLKLIAV LEKETTQLRE
QVGRLESELN HEKERCDQLQ AEQKGLVEVS ESLKTENEEF KKRYNDATSK ALQLEEDIVS
VTHKAIEKET ELDSLKDKLR KAQYEREQLE CQLKTEKDEK ELYKVHLKNT EIENTKLVSE
VQTLKNLDGN KESMITHFKE EIGRLQFCLA EKENLQRAFL LTTSSKEDTF SLKEQLRKAE
EQVQATRQEV VFLGKELSDA VNVRDKTMAD LHTARLENEK VKKQLADAVA ELKLNAVKKD
QEKTDTLEHE LRREVEDLKL RLQMAADHYK EKFKECQRLQ KQINKLSDQS ASSNSVLTKK
TGNQQKVNDA SINTDPAATA STIDVKPPPS AAETDSDMIT KGQVYEMTKE IADKTEKYNK
CRQLLQDEKT KCNKYADELA KMELKWKEQV KIAENVKLAL AEVEDNYRLQ LAEKDKEING
LTSRLENLSR EKELKRNLED QAERKMEGQN SQSPQKISQC LNTCSEQNGH FATVPHTQPV
LQYGNPYATQ EARDGADGAF YPDEIQRPPV RVPSWGLEDN VVCSQPARNL SRPDGLEDPE
DSQEEENVPS APDPPGQHLR GRGAGFCFDS SFDVHKKCPL CELMFPPNYD QSKFEEHVES
HWKVCPMCSE QFPPDYDQQG FERHVQTHFD QNVLNFD
//
