ID D2GYA5_AILME Unreviewed; 434 AA.
AC D2GYA5;
DT 09-FEB-2010, integrated into UniProtKB/TrEMBL.
DT 09-FEB-2010, sequence version 1.
DT 24-JAN-2024, entry version 59.
DE RecName: Full=RING-type domain-containing protein {ECO:0000259|PROSITE:PS50089};
DE Flags: Fragment;
GN ORFNames=PANDA_001957 {ECO:0000313|EMBL:EFB23403.1};
OS Ailuropoda melanoleuca (Giant panda).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX NCBI_TaxID=9646 {ECO:0000313|EMBL:EFB23403.1};
RN [1] {ECO:0000313|EMBL:EFB23403.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20010809; DOI=10.1038/nature08696;
RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA Wang J.;
RT "The sequence and de novo assembly of the giant panda genome.";
RL Nature 463:311-317(2010).
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DR EMBL; GL192378; EFB23403.1; -; Genomic_DNA.
DR AlphaFoldDB; D2GYA5; -.
DR STRING; 9646.ENSAMEP00000020762; -.
DR eggNOG; KOG4265; Eukaryota.
DR HOGENOM; CLU_057705_0_0_1; -.
DR InParanoid; D2GYA5; -.
DR OMA; RMTDVMA; -.
DR TreeFam; TF331813; -.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:Ensembl.
DR GO; GO:0007032; P:endosome organization; IEA:Ensembl.
DR GO; GO:0050687; P:negative regulation of defense response to virus; IEA:Ensembl.
DR GO; GO:0070979; P:protein K11-linked ubiquitination; IEA:Ensembl.
DR GO; GO:1905719; P:protein localization to perinuclear region of cytoplasm; IEA:Ensembl.
DR GO; GO:0032479; P:regulation of type I interferon production; IEA:Ensembl.
DR CDD; cd16788; mRING-HC-C3HC5_RNF26; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR040089; RNF26_mRING-HC-C3HC5.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR22696; E3 UBIQUITIN-PROTEIN LIGASE RNF26; 1.
DR PANTHER; PTHR22696:SF1; E3 UBIQUITIN-PROTEIN LIGASE RNF26; 1.
DR Pfam; PF13920; zf-C3HC4_3; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT TRANSMEM 24..44
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 56..77
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 151..170
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 182..203
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 223..246
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 381..423
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REGION 302..342
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 434
FT /evidence="ECO:0000313|EMBL:EFB23403.1"
SQ SEQUENCE 434 AA; 47886 MW; 24C9C0F7D59A0C0E CRC64;
MEAVYLIVNG VGLVLDLLTL VLDLNFLLVS SLLASLAWLL AFIYNLPHTV LTSLLHLGRG
VLLSLLALIE ALVRFTFGGL QALCTLLYSC CSGLESLKLL GHLASHGALR SREILHRGVL
NVVSNGHALL RQVCDICAIA MSLVAYVINS LVNICLIGTQ NLFSLMLALW DAVTGPLWRM
TDVVAAFLAH ISSSAVAMAI LLWTPCQLAL ELLASAVRLL ASFVLVNVTG LVLLACVLAV
MVTVLHPDLT LRLATRALSQ LHARPSYHRL REDVVRLSRL ALDLEAWRRV WSRSLQLATW
PNRGGAPGAP QGGPRRVPSA RTWRQDTLPE AGSRSEAEEE EEVRMARATA ARGRERLNEE
ESIAGQDPWQ LLKEQEERKK CVICQDQSKT VLLLPCRHLC LCQACTEILM RHPISHRNCP
LCRRGILQTL NVYL
//
