ID D2H842_AILME Unreviewed; 379 AA.
AC D2H842;
DT 09-FEB-2010, integrated into UniProtKB/TrEMBL.
DT 09-FEB-2010, sequence version 1.
DT 08-NOV-2023, entry version 70.
DE RecName: Full=exo-alpha-sialidase {ECO:0000256|ARBA:ARBA00012733};
DE EC=3.2.1.18 {ECO:0000256|ARBA:ARBA00012733};
DE Flags: Fragment;
GN ORFNames=PANDA_006378 {ECO:0000313|EMBL:EFB20651.1};
OS Ailuropoda melanoleuca (Giant panda).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX NCBI_TaxID=9646 {ECO:0000313|EMBL:EFB20651.1};
RN [1] {ECO:0000313|EMBL:EFB20651.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20010809; DOI=10.1038/nature08696;
RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA Wang J.;
RT "The sequence and de novo assembly of the giant panda genome.";
RL Nature 463:311-317(2010).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-
CC (2->8)- glycosidic linkages of terminal sialic acid residues in
CC oligosaccharides, glycoproteins, glycolipids, colominic acid and
CC synthetic substrates.; EC=3.2.1.18;
CC Evidence={ECO:0000256|ARBA:ARBA00000427};
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 33 family.
CC {ECO:0000256|ARBA:ARBA00009348}.
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DR EMBL; GL192569; EFB20651.1; -; Genomic_DNA.
DR RefSeq; XP_002918012.1; XM_002917966.2.
DR AlphaFoldDB; D2H842; -.
DR STRING; 9646.ENSAMEP00000017315; -.
DR eggNOG; ENOG502QSFT; Eukaryota.
DR HOGENOM; CLU_024620_2_1_1; -.
DR InParanoid; D2H842; -.
DR OMA; SDHGTTW; -.
DR OrthoDB; 5482010at2759; -.
DR TreeFam; TF331063; -.
DR GO; GO:1902494; C:catalytic complex; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0052794; F:exo-alpha-(2->3)-sialidase activity; IEA:UniProtKB-EC.
DR GO; GO:0052795; F:exo-alpha-(2->6)-sialidase activity; IEA:UniProtKB-EC.
DR GO; GO:0052796; F:exo-alpha-(2->8)-sialidase activity; IEA:UniProtKB-EC.
DR GO; GO:0006689; P:ganglioside catabolic process; IEA:Ensembl.
DR GO; GO:0006516; P:glycoprotein catabolic process; IEA:Ensembl.
DR GO; GO:0009313; P:oligosaccharide catabolic process; IEA:Ensembl.
DR CDD; cd15482; Sialidase_non-viral; 1.
DR Gene3D; 2.120.10.10; -; 1.
DR InterPro; IPR011040; Sialidase.
DR InterPro; IPR026856; Sialidase_fam.
DR InterPro; IPR036278; Sialidase_sf.
DR PANTHER; PTHR10628; SIALIDASE; 1.
DR PANTHER; PTHR10628:SF6; SIALIDASE-2; 1.
DR Pfam; PF13088; BNR_2; 1.
DR SUPFAM; SSF50939; Sialidases; 1.
PE 3: Inferred from homology;
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022963}.
FT DOMAIN 33..340
FT /note="Sialidase"
FT /evidence="ECO:0000259|Pfam:PF13088"
FT NON_TER 379
FT /evidence="ECO:0000313|EMBL:EFB20651.1"
SQ SEQUENCE 379 AA; 42134 MW; 88AC8D26ADB7898C CRC64;
MASCPVLQKE RVFQSGDHAY RIPALLYLPQ QKTLLAFAEK RMSKKDEHAE LIVLRRGSYD
ASTHHVQWHA QEVVAQAQLE GHRSMNPSPL YDEKTGTLFL FFIAIPGQVS EHHQIHTRVN
VTRLCQVTST NHGRSWSPAR DLTGPAIGAA HKEWATFAVG PGHCLQLHNK TQSLVVPAYA
YRNLHSIQGP SPFAFCFVSH DHGHTWKRGN FVAQDTLECQ VAEVGGARQR VVYLNARSPL
RARVQAESTN EGLDFQEAQT VKKLVEPPHG CHGSVISFPN PREGSGASDK WLLYTHPTDP
QQRADLGVYL NKRLPGPEAW SEPALLATGS CAYSDLQSMG VGPDGSPQFG CLYESDNYEE
VVFLMFTLKQ AFPAEFLSQ
//