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Database: UniProt
Entry: D2H9M0_AILME
LinkDB: D2H9M0_AILME
Original site: D2H9M0_AILME 
ID   D2H9M0_AILME            Unreviewed;      1503 AA.
AC   D2H9M0;
DT   09-FEB-2010, integrated into UniProtKB/TrEMBL.
DT   09-FEB-2010, sequence version 1.
DT   16-OCT-2019, entry version 68.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:EFB13209.1, ECO:0000313|Ensembl:ENSAMEP00000016572};
DE   Flags: Fragment;
GN   Name=ARHGAP5 {ECO:0000313|Ensembl:ENSAMEP00000016572};
GN   ORFNames=PANDA_007030 {ECO:0000313|EMBL:EFB13209.1};
OS   Ailuropoda melanoleuca (Giant panda).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae;
OC   Ailuropoda.
OX   NCBI_TaxID=9646 {ECO:0000313|EMBL:EFB13209.1};
RN   [1] {ECO:0000313|EMBL:EFB13209.1, ECO:0000313|Ensembl:ENSAMEP00000016572}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=20010809; DOI=10.1038/nature08696;
RA   Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q.,
RA   Li B., Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H.,
RA   Jian M., Li J., Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z.,
RA   Ryder O.A., Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X.,
RA   Guo X., Wang B., Hou R., Shen F., Mu B., Ni P., Lin R., Qian W.,
RA   Wang G., Yu C., Nie W., Wang J., Wu Z., Liang H., Min J., Wu Q.,
RA   Cheng S., Ruan J., Wang M., Shi Z., Wen M., Liu B., Ren X., Zheng H.,
RA   Dong D., Cook K., Shan G., Zhang H., Kosiol C., Xie X., Lu Z.,
RA   Zheng H., Li Y., Steiner C.C., Lam T.T., Lin S., Zhang Q., Li G.,
RA   Tian J., Gong T., Liu H., Zhang D., Fang L., Ye C., Zhang J., Hu W.,
RA   Xu A., Ren Y., Zhang G., Bruford M.W., Li Q., Ma L., Guo Y., An N.,
RA   Hu Y., Zheng Y., Shi Y., Li Z., Liu Q., Chen Y., Zhao J., Qu N.,
RA   Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X., Vinar T., Wang Y.,
RA   Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y., Wang X.,
RA   Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA   Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H.,
RA   Wang J., Wang J.;
RT   "The sequence and de novo assembly of the giant panda genome.";
RL   Nature 463:311-317(2010).
RN   [2] {ECO:0000313|Ensembl:ENSAMEP00000016572}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
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DR   EMBL; ACTA01106441; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACTA01114441; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACTA01122441; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACTA01130441; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACTA01138441; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACTA01146440; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACTA01154439; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACTA01162438; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACTA01170436; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; GL192604; EFB13209.1; -; Genomic_DNA.
DR   RefSeq; XP_002918557.1; XM_002918511.3.
DR   RefSeq; XP_019654500.1; XM_019798941.1.
DR   STRING; 9646.ENSAMEP00000016572; -.
DR   Ensembl; ENSAMET00000017256; ENSAMEP00000016572; ENSAMEG00000015709.
DR   GeneID; 100471100; -.
DR   KEGG; aml:100471100; -.
DR   CTD; 394; -.
DR   eggNOG; KOG4271; Eukaryota.
DR   eggNOG; ENOG410XR4E; LUCA.
DR   GeneTree; ENSGT00940000154553; -.
DR   HOGENOM; HOG000001561; -.
DR   KO; K13709; -.
DR   OMA; HIDKVND; -.
DR   OrthoDB; 110157at2759; -.
DR   TreeFam; TF324451; -.
DR   Proteomes; UP000008912; Unassembled WGS sequence.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl.
DR   GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   GO; GO:0042169; F:SH2 domain binding; IEA:Ensembl.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   Gene3D; 1.10.10.440; -; 3.
DR   Gene3D; 1.10.555.10; -; 1.
DR   InterPro; IPR002713; FF_domain.
DR   InterPro; IPR036517; FF_domain_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR039007; pG1.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR032835; RhoGAP-FF1.
DR   InterPro; IPR000198; RhoGAP_dom.
DR   InterPro; IPR039006; RhoGAP_pG2.
DR   InterPro; IPR001806; Small_GTPase.
DR   Pfam; PF01846; FF; 1.
DR   Pfam; PF00071; Ras; 1.
DR   Pfam; PF00620; RhoGAP; 1.
DR   Pfam; PF16512; RhoGAP-FF1; 1.
DR   SMART; SM00441; FF; 4.
DR   SMART; SM00324; RhoGAP; 1.
DR   SUPFAM; SSF48350; SSF48350; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF81698; SSF81698; 1.
DR   PROSITE; PS51676; FF; 4.
DR   PROSITE; PS51852; PG1; 1.
DR   PROSITE; PS51853; PG2; 1.
DR   PROSITE; PS50238; RHOGAP; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008912};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008912}.
FT   DOMAIN      267    325       FF. {ECO:0000259|PROSITE:PS51676}.
FT   DOMAIN      366    420       FF. {ECO:0000259|PROSITE:PS51676}.
FT   DOMAIN      427    481       FF. {ECO:0000259|PROSITE:PS51676}.
FT   DOMAIN      482    548       FF. {ECO:0000259|PROSITE:PS51676}.
FT   DOMAIN      590    763       PG1 pseudoGTPase. {ECO:0000259|PROSITE:
FT                                PS51852}.
FT   DOMAIN      779    944       PG2 pseudoGTPase. {ECO:0000259|PROSITE:
FT                                PS51853}.
FT   DOMAIN     1263   1450       Rho-GAP. {ECO:0000259|PROSITE:PS50238}.
FT   REGION      975   1004       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION     1022   1050       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION     1069   1089       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION     1129   1157       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION     1169   1255       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COILED      309    329       {ECO:0000256|SAM:Coils}.
FT   COMPBIAS   1024   1038       Polyampholyte. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COMPBIAS   1169   1200       Polyampholyte. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COMPBIAS   1232   1249       Basic. {ECO:0000256|SAM:MobiDB-lite}.
FT   NON_TER    1503   1503       {ECO:0000313|EMBL:EFB13209.1}.
SQ   SEQUENCE   1503 AA;  172484 MW;  50C68A18273AD714 CRC64;
     MMAKNKEPRP PSYTISVVGL SGTEKDKGNC GVGKSCLCNR FVRSKADEYY PEHTSVLSTI
     DFGGRVVNND HFLYWGDITQ NGEDGVECKI HVIEQTEFID DQTFLPHRST NLQPYIKRAA
     ASKLQSAEKL MYICTDQLGL EQDFEQKQMP EGKLNVDGFL LCIDVSQGCN RKFDDQLKFV
     NNLFVQLSKS KKPVIIAATK CDECVDHYLR EVQAFASNKK NLLVVETSAR FNVNIETCFT
     ALVQMLDKTR GKPKIIPYLD AYKTQRQLVV TATDKFEKLV QTVRDYHATW KTVSNKLKNH
     PDYEEYINLE GTRKARNTFS KHIEQLKQEH IRKRREEYIN TLPRAFNTLL PNLEEIEHLN
     WSEALKLMEK RADFQLCFVV LEKTPWDETD HIDKINDRRI PFDLLGTLEA EKVYQNHVQH
     LISEKRRVEM KEKFKKTLEK IQFISPGQPW EEVMCFVMED EAFKYITEAD SKEVYGRHQR
     EIVEKAKEEF QEMLFEHSEL FYDLDLNATP SSDKMSEIHT VLSEEPRYKA LQKLAPDRES
     LLLKHIGFVY HPTKETCLSG QNCTDIKVEQ LLASRLLQLD HGRLRLYHDS TSIDKVNLFI
     LGKDGLAQEL ANEIRTQSTD DEYALDGKIY ELDLRPVDAK SPYFLSQLWT AAFKPHGCFC
     VFNSIESLNF IGEFIGKIRT EASQIRKDKY MANLPFTLIL ANQRDSMSKN LPILRHQGQQ
     LANKLQCPFV DVPPGTYPRK FNETQIKQAL RGVLESVKHN LDVVSPVPTS KDVSEADLRI
     VMCAMCGDPF SVDLILSPFL DSHSCSAAQA GQNNSLMLDK IIGEKRRRIQ ITILSYHSSI
     GVRKDELVHG YILVYSAKRK ASMGMLRAFL SEVQDTIPVQ LVAVTDSQAD FFENEAIKEL
     MTEGEHIATE ITAKFTALYS LSQYHRQTEV FTLFFSDVLE KKNMIENSYL SDNTRESTHQ
     SEDVFLPSPR DCFPYNNYPD SDDDTEAPPP YSPIGDDVQL LPTPSDRSRY RLDLEGNEYP
     IHSTPNCHDH ERNHKVPPPI KPKPVVPKTN VKKLDPNLVK TIEAGIGKNP RKQTSRVPLA
     HPEDMDPSDN YAEPIDTIFK QKGYSDETYV VPDDSQTRII KIRNSFVNNT QGDEENGFSD
     RTSKSHGERR PSKYKYKSKT LFSKAKSYYR RTHSDASDDE AFTTSKTKRK GRHRGSEEDP
     LLSPVETWKG GIDNPAITSD QELDDKKMKK KTHKVKEDKK QKKKTKNFNP PTRRNWESNY
     FGMPLQDLVT AEKPIPLFVE KCVEFIEDTG LCTEGLYRVS GNKTDQDNIQ KQFDQDHNIS
     LVSMEVTVNA VAGALKAFFA DLPDPLIPYS LHPELLEAAK IPDKTERLHA LKEIVRKFHP
     VNYDVFRYVI THLNRVSQQN KINLMTADNL SICFWPTLMR PDFENREFLS TTKIHQSVVE
     TFIQQCQFFF YNGEIVETVN TVTPPPPSNP GQLVEPMVPL QLPPPLQPQL IQPQLQTDPL
     GII
//
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