ID D2HIK2_AILME Unreviewed; 771 AA.
AC D2HIK2;
DT 09-FEB-2010, integrated into UniProtKB/TrEMBL.
DT 09-FEB-2010, sequence version 1.
DT 27-MAR-2024, entry version 84.
DE SubName: Full=Cadherin 19 {ECO:0000313|Ensembl:ENSAMEP00000032831.1};
DE Flags: Fragment;
GN Name=CDH19 {ECO:0000313|Ensembl:ENSAMEP00000032831.1};
GN ORFNames=PANDA_011042 {ECO:0000313|EMBL:EFB20834.1};
OS Ailuropoda melanoleuca (Giant panda).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX NCBI_TaxID=9646 {ECO:0000313|EMBL:EFB20834.1};
RN [1] {ECO:0000313|EMBL:EFB20834.1, ECO:0000313|Proteomes:UP000008912}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20010809; DOI=10.1038/nature08696;
RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA Wang J.;
RT "The sequence and de novo assembly of the giant panda genome.";
RL Nature 463:311-317(2010).
RN [2] {ECO:0000313|Ensembl:ENSAMEP00000032831.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Cadherins are calcium-dependent cell adhesion proteins.
CC {ECO:0000256|RuleBase:RU004357}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251,
CC ECO:0000256|RuleBase:RU003318}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|RuleBase:RU003318}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}.
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DR EMBL; GL192888; EFB20834.1; -; Genomic_DNA.
DR RefSeq; XP_002922100.1; XM_002922054.3.
DR STRING; 9646.ENSAMEP00000017748; -.
DR Ensembl; ENSAMET00000050214.1; ENSAMEP00000032831.1; ENSAMEG00000016780.2.
DR GeneID; 100468095; -.
DR KEGG; aml:100468095; -.
DR CTD; 28513; -.
DR eggNOG; KOG3594; Eukaryota.
DR GeneTree; ENSGT00940000160137; -.
DR HOGENOM; CLU_005284_3_1_1; -.
DR OMA; TIYVCDC; -.
DR OrthoDB; 3667774at2759; -.
DR TreeFam; TF329887; -.
DR Proteomes; UP000008912; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 5.
DR Gene3D; 2.60.40.60; Cadherins; 5.
DR Gene3D; 4.10.900.10; TCF3-CBD (Catenin binding domain); 1.
DR InterPro; IPR039808; Cadherin.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR000233; Cadherin_Y-type_LIR.
DR InterPro; IPR027397; Catenin-bd_sf.
DR PANTHER; PTHR24027:SF323; CADHERIN-19; 1.
DR PANTHER; PTHR24027; CADHERIN-23; 1.
DR Pfam; PF01049; CADH_Y-type_LIR; 1.
DR Pfam; PF00028; Cadherin; 4.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 5.
DR SUPFAM; SSF49313; Cadherin-like; 5.
DR PROSITE; PS00232; CADHERIN_1; 1.
DR PROSITE; PS50268; CADHERIN_2; 5.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043};
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003318};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008912};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003318};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..771
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015088318"
FT TRANSMEM 596..617
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 68..148
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 149..256
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 257..369
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 370..469
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 469..580
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT NON_TER 771
FT /evidence="ECO:0000313|EMBL:EFB20834.1"
SQ SEQUENCE 771 AA; 86903 MW; D140D45F3C04BDCF CRC64;
MICCLFLPFM LGIPLLWPCF TAIEISTTEK VKHPAGSHLR VKRGWMWNQF FVPEEMNKTN
YHIGQLRSDL DNGNNSFQYK LLGAGAGSIF VIDERTGDIY AVQKLDREER SLYTLRAQVI
DSTTGRAVEP ESEFVIRVSD INDNEPKFLD EPYEAIVPEM SPEGTLVIQV TASDADDPSS
GNNARLLYSL LQGQPYFSTE PTTGVIRISS KMDRELQDEY WVIIQAKDMI GLPGALSGTT
SVLIKLSDVN DNKPIFKESL YRLTVSESAP AGTSIGKIMA YDNDIGENAE MDYSIEDDSQ
TFDVITNNET QEGIVILKKE VDFEHQNQYR IRANVKNRHV DEQLMEYHVE ASTTFIRIQV
EDEDEPPVFL LPYYVFEIFE ESPHGSFVGM VSATDPDQRN SPIRYSMTRS RVFSIDDNGT
IITTNPLDRE ISAWYNLSII ATEEYNVQQI SAVPVYVQVL NINDHAPEFS EYYDTYVCEN
AGSGQIIQTI SAVDRDESIE GHHFYFNLSV EDTKNSSFII IDNEDNTAVI LTNRTGFSLQ
EEPVFYIAVL IADNGIPSLT STNTLTVHIC DCDDSGSTQT CRNKDLMLAM GFRTEVILAI
LISIMIIFGF IFLILGLKQR RKQTLFPEKG EDFRENIFRY DDEGGGEEDT EAFDIVALRT
RTIMRERKTR KTAAAEIRSL HRQSLQVGPD SAIFRKFILE KLEEANTDPC APPFDSLQTY
AFEGTGSLAG SLSSLGSAVP DQDENYDYLN ESGPRFKRLA CMFGSAMQSN N
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