ID D2HPM5_AILME Unreviewed; 1167 AA.
AC D2HPM5;
DT 09-FEB-2010, integrated into UniProtKB/TrEMBL.
DT 09-FEB-2010, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:EFB30079.1};
DE Flags: Fragment;
GN ORFNames=PANDA_013744 {ECO:0000313|EMBL:EFB30079.1};
OS Ailuropoda melanoleuca (Giant panda).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX NCBI_TaxID=9646 {ECO:0000313|EMBL:EFB30079.1};
RN [1] {ECO:0000313|EMBL:EFB30079.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20010809; DOI=10.1038/nature08696;
RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA Wang J.;
RT "The sequence and de novo assembly of the giant panda genome.";
RL Nature 463:311-317(2010).
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DR EMBL; GL193142; EFB30079.1; -; Genomic_DNA.
DR AlphaFoldDB; D2HPM5; -.
DR STRING; 9646.ENSAMEP00000004480; -.
DR eggNOG; ENOG502QQPT; Eukaryota.
DR HOGENOM; CLU_011546_0_0_1; -.
DR InParanoid; D2HPM5; -.
DR OMA; NRMASYS; -.
DR TreeFam; TF325466; -.
DR GO; GO:0005884; C:actin filament; IEA:Ensembl.
DR GO; GO:0005938; C:cell cortex; IEA:Ensembl.
DR GO; GO:0030027; C:lamellipodium; IEA:Ensembl.
DR GO; GO:0005811; C:lipid droplet; IEA:Ensembl.
DR GO; GO:0005765; C:lysosomal membrane; IEA:Ensembl.
DR GO; GO:0014069; C:postsynaptic density; IEA:Ensembl.
DR GO; GO:0101031; C:protein folding chaperone complex; IEA:Ensembl.
DR GO; GO:0033596; C:TSC1-TSC2 complex; IEA:Ensembl.
DR GO; GO:0042030; F:ATPase inhibitor activity; IEA:Ensembl.
DR GO; GO:0030544; F:Hsp70 protein binding; IEA:Ensembl.
DR GO; GO:0051879; F:Hsp90 protein binding; IEA:Ensembl.
DR GO; GO:0002250; P:adaptive immune response; IEA:Ensembl.
DR GO; GO:0008306; P:associative learning; IEA:Ensembl.
DR GO; GO:0055007; P:cardiac muscle cell differentiation; IEA:Ensembl.
DR GO; GO:0008283; P:cell population proliferation; IEA:Ensembl.
DR GO; GO:0030030; P:cell projection organization; IEA:Ensembl.
DR GO; GO:0007160; P:cell-matrix adhesion; IEA:Ensembl.
DR GO; GO:0009267; P:cellular response to starvation; IEA:Ensembl.
DR GO; GO:0021987; P:cerebral cortex development; IEA:Ensembl.
DR GO; GO:0046323; P:glucose import; IEA:Ensembl.
DR GO; GO:0021766; P:hippocampus development; IEA:Ensembl.
DR GO; GO:0001822; P:kidney development; IEA:Ensembl.
DR GO; GO:0043379; P:memory T cell differentiation; IEA:Ensembl.
DR GO; GO:0042552; P:myelination; IEA:Ensembl.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; IEA:Ensembl.
DR GO; GO:0045792; P:negative regulation of cell size; IEA:Ensembl.
DR GO; GO:1904262; P:negative regulation of TORC1 signaling; IEA:Ensembl.
DR GO; GO:0017148; P:negative regulation of translation; IEA:Ensembl.
DR GO; GO:0001843; P:neural tube closure; IEA:Ensembl.
DR GO; GO:0051894; P:positive regulation of focal adhesion assembly; IEA:Ensembl.
DR GO; GO:0006813; P:potassium ion transport; IEA:Ensembl.
DR GO; GO:0050821; P:protein stabilization; IEA:Ensembl.
DR GO; GO:0051492; P:regulation of stress fiber assembly; IEA:Ensembl.
DR GO; GO:0032868; P:response to insulin; IEA:Ensembl.
DR GO; GO:0006407; P:rRNA export from nucleus; IEA:Ensembl.
DR GO; GO:0050808; P:synapse organization; IEA:Ensembl.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR007483; Hamartin.
DR PANTHER; PTHR15154; HAMARTIN; 1.
DR PANTHER; PTHR15154:SF2; HAMARTIN; 1.
DR Pfam; PF04388; Hamartin; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils}.
FT REGION 413..454
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 512..569
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1007..1058
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1068..1087
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1122..1167
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 726..820
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 417..444
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 523..537
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1042..1058
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1068..1086
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1167
FT /evidence="ECO:0000313|EMBL:EFB30079.1"
SQ SEQUENCE 1167 AA; 129053 MW; FB71E7EC440D2F94 CRC64;
MAQQANLGEL LSMLDSPVLS VRDEVTAVFK ENLSSDRGPM LVNTLVDYYL ETNSQPVLHI
LTTLQEPHDK HLLDKMNDCM GRAASRLPAL SLLGHVIRLQ PPWKHKLSQA PLLPSLLKCL
KVDTDVIVLT TGVLVLITML PMIPQSGKQH LHDFFDIFGR LSSWCLKKPG HVTEIYLVHL
HASVYALFHR LYGMYPCNFV SFLRSHYSMK ENLDTFEEVV RPMMEHVRIH PELVTGSKDH
ELDPRRWKRL ETHDVVIECA KISLDPAEAS YEDGDSVSPQ VSARFPHRAA DVAASPYVDM
QNSCGSATST PYSSSRLTLF STPGQPPQIL SPPSTGLLTE PPQATLWSPS MVCGMTTPPT
SPGNVPPDLS HPYSKVFGTT AGGKGTPLGT PATSPPPAPL CHSDDYVHIS LRQATATPPK
KEEKTDSARP CLHRQHHLPN DRGLEELPGS KGSVPLSDLP GFLGDLDSEE DSIEKAKEEA
AISKELSEIT TAGTGPLVPR GGFDSPFYRD SLPGCPRKNH SAATGAQGAS MNPEPLNSSL
DKLGPDTPKQ AFTPIDPPCG GANQSPAGSR ERQTVLETDI LTPSPCKIPP QRGVGFGSGQ
PPPYDHLFEV ALPKTAHHFV SKKTKELLKK AKGNAEEDCP PSTSPAEVLD RLIQQGADAH
SKELNKLSLP SKSVDWTHFG GSPPSDEIRT LRNQLLLLHN QLLYERFKRQ QHALRNRRLL
RRVIRAAALE EHNAAMKDQL KLQEKDIQIW KVSMQKEQAR YSQLQEQRDT MVTQLHSQIR
QLQHDREEFY NQSQELQTKL EDCRNMIAEL RLELKKANSK VCHTELLLSQ VSQKLSNSES
VQQQMEFLNR QLLVLGEVNE LYLEQLQSKH SDTTKEVEMM KAACRKELEK NRSHVLQQNQ
RLDTSQKRIL ELESHLAKKD HLLLEQKKYL EDVKVQARGQ LQAAESRYEA QKRITQVFEL
EILDLYGRLE KDGLLKKLEE EKAEAAEAAE ERLACCKDGC SDSVTGHNEE ASGHNGETKP
PRPGGGVRGG GASRGGGGGS GGGSSELSTP EKPPTQRAGL FSSRWETTVG ESATSIPTTV
GSFPSSKSFL GMKARELFRN KSESHCDEDS VTISSLSETL KTELGKDPGA EVKTPLNLDG
PHPSPPNPDS VGQLHIMDYN ETHHEHS
//
