ID D2HTP5_AILME Unreviewed; 96 AA.
AC D2HTP5;
DT 09-FEB-2010, integrated into UniProtKB/TrEMBL.
DT 09-FEB-2010, sequence version 1.
DT 03-MAY-2023, entry version 43.
DE RecName: Full=SOSS complex subunit C {ECO:0000256|ARBA:ARBA00014540, ECO:0000256|RuleBase:RU369016};
DE Short=SOSS-C {ECO:0000256|RuleBase:RU369016};
DE Short=SSB-interacting protein 1 {ECO:0000256|RuleBase:RU369016};
DE AltName: Full=Sensor of single-strand DNA complex subunit C {ECO:0000256|ARBA:ARBA00030383, ECO:0000256|RuleBase:RU369016};
DE AltName: Full=Sensor of ssDNA subunit C {ECO:0000256|ARBA:ARBA00033066, ECO:0000256|RuleBase:RU369016};
DE AltName: Full=Single-stranded DNA-binding protein-interacting protein 1 {ECO:0000256|ARBA:ARBA00031967, ECO:0000256|RuleBase:RU369016};
DE Flags: Fragment;
GN ORFNames=PANDA_015570 {ECO:0000313|EMBL:EFB21568.1};
OS Ailuropoda melanoleuca (Giant panda).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX NCBI_TaxID=9646 {ECO:0000313|EMBL:EFB21568.1};
RN [1] {ECO:0000313|EMBL:EFB21568.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20010809; DOI=10.1038/nature08696;
RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA Wang J.;
RT "The sequence and de novo assembly of the giant panda genome.";
RL Nature 463:311-317(2010).
CC -!- FUNCTION: Component of the SOSS complex, a multiprotein complex that
CC functions downstream of the MRN complex to promote DNA repair and G2/M
CC checkpoint. The SOSS complex associates with single-stranded DNA at DNA
CC lesions and influences diverse endpoints in the cellular DNA damage
CC response including cell-cycle checkpoint activation, recombinational
CC repair and maintenance of genomic stability. Required for efficient
CC homologous recombination-dependent repair of double-strand breaks
CC (DSBs). {ECO:0000256|RuleBase:RU369016}.
CC -!- SUBUNIT: Component of the SOSS complex.
CC {ECO:0000256|RuleBase:RU369016}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU369016}.
CC -!- SIMILARITY: Belongs to the SOSS-C family.
CC {ECO:0000256|ARBA:ARBA00007829, ECO:0000256|RuleBase:RU369016}.
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DR EMBL; GL193361; EFB21568.1; -; Genomic_DNA.
DR AlphaFoldDB; D2HTP5; -.
DR STRING; 9646.ENSAMEP00000007204; -.
DR eggNOG; ENOG502S23S; Eukaryota.
DR HOGENOM; CLU_145773_1_0_1; -.
DR InParanoid; D2HTP5; -.
DR OMA; MTSNPPG; -.
DR TreeFam; TF328613; -.
DR GO; GO:0070876; C:SOSS complex; IEA:UniProtKB-UniRule.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR GO; GO:0010212; P:response to ionizing radiation; IEA:UniProtKB-UniRule.
DR InterPro; IPR031821; SOSSC.
DR PANTHER; PTHR31526; SOSS COMPLEX SUBUNIT C; 1.
DR PANTHER; PTHR31526:SF2; SOSS COMPLEX SUBUNIT C; 1.
DR Pfam; PF15925; SOSSC; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|RuleBase:RU369016};
KW DNA repair {ECO:0000256|RuleBase:RU369016};
KW Nucleus {ECO:0000256|RuleBase:RU369016}.
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EFB21568.1"
FT NON_TER 96
FT /evidence="ECO:0000313|EMBL:EFB21568.1"
SQ SEQUENCE 96 AA; 10678 MW; C29689AE61687B04 CRC64;
GFQNKNRVAI LAELDKEKRK LLMQNQSSTN HPGASIALSR PSLNKDFRDH AEQQHIAAQQ
KAALQHAHAH SSGYFITQDS AFGNLILPVL PRLDPE
//
