ID D2I7K2_AILME Unreviewed; 500 AA.
AC D2I7K2;
DT 09-FEB-2010, integrated into UniProtKB/TrEMBL.
DT 09-FEB-2010, sequence version 1.
DT 13-SEP-2023, entry version 63.
DE RecName: Full=Ribonucleotide reductase large subunit domain-containing protein {ECO:0000259|PROSITE:PS00089};
DE Flags: Fragment;
GN ORFNames=PANDA_021921 {ECO:0000313|EMBL:EFB14732.1};
OS Ailuropoda melanoleuca (Giant panda).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX NCBI_TaxID=9646 {ECO:0000313|EMBL:EFB14732.1};
RN [1] {ECO:0000313|EMBL:EFB14732.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20010809; DOI=10.1038/nature08696;
RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA Wang J.;
RT "The sequence and de novo assembly of the giant panda genome.";
RL Nature 463:311-317(2010).
CC -!- SIMILARITY: Belongs to the ribonucleoside diphosphate reductase large
CC chain family. {ECO:0000256|ARBA:ARBA00010406}.
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DR EMBL; GL195394; EFB14732.1; -; Genomic_DNA.
DR AlphaFoldDB; D2I7K2; -.
DR STRING; 9646.ENSAMEP00000009253; -.
DR eggNOG; KOG1112; Eukaryota.
DR HOGENOM; CLU_000404_6_1_1; -.
DR InParanoid; D2I7K2; -.
DR OMA; WSAIMES; -.
DR TreeFam; TF300578; -.
DR GO; GO:0009263; P:deoxyribonucleotide biosynthetic process; IEA:UniProtKB-KW.
DR CDD; cd01679; RNR_I; 1.
DR Gene3D; 3.20.70.20; -; 1.
DR InterPro; IPR013346; NrdE_NrdA_C.
DR InterPro; IPR000788; RNR_lg_C.
DR InterPro; IPR039718; Rrm1.
DR NCBIfam; TIGR02506; NrdE_NrdA; 1.
DR PANTHER; PTHR11573; RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE CHAIN; 1.
DR PANTHER; PTHR11573:SF6; RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT; 1.
DR Pfam; PF02867; Ribonuc_red_lgC; 1.
DR PRINTS; PR01183; RIBORDTASEM1.
DR SUPFAM; SSF51998; PFL-like glycyl radical enzymes; 1.
DR PROSITE; PS00089; RIBORED_LARGE; 1.
PE 3: Inferred from homology;
KW Deoxyribonucleotide synthesis {ECO:0000256|ARBA:ARBA00023116}.
FT DOMAIN 289..311
FT /note="Ribonucleotide reductase large subunit"
FT /evidence="ECO:0000259|PROSITE:PS00089"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EFB14732.1"
FT NON_TER 500
FT /evidence="ECO:0000313|EMBL:EFB14732.1"
SQ SEQUENCE 500 AA; 57696 MW; 12303659014D0D3D CRC64;
RPGAFAIYLE PWHLDIFEFL DLKKNTGKEE QRARDLFFAL WIPDLFMKRV ETNQDWSLMC
PNECPGLDEV WGEEFEKLYE SYEKQGRVRK VVKAQQLWYA IIESQTETGT PYMLYKDSCN
RKSNQQNLGT IKCSNLCTEI VEYTSKDEVA VCNLASVALN MYVTSEHTYD FKKLAEVTKV
IVRNLNKIID INYYPVPEAC LSNKRHRPIG IGVQGLADAF ILMRYPFESP EAQLLNKQIF
ETIYYGALEA SCDLAREHGP YETYEGSPVS RGILQYDMWN VTPTDLWDWK LLKEKIAKYG
IRNSLLIAPM PTASTAQILG NNESIEPYTS NIYTRRVLSG EFQIVNPHLL KDLTERGLWN
EEMKNQIIAC NGSIQSIPEI PDDLKQLYKT VWEISQKTVL KMAAERGAFI DQSQSLNIHI
AEPNYGKLTS MHFYGWKQGL KTGMYYLRTR PAANPIQFTL NKEKLKDKEK ATKEEEEKER
NTAAMVCSLE NREECLMCGS
//
