ID D2NU01_ROTMD Unreviewed; 652 AA.
AC D2NU01;
DT 02-MAR-2010, integrated into UniProtKB/TrEMBL.
DT 02-MAR-2010, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Predicted nucleoside-diphosphate sugar epimerase {ECO:0000313|EMBL:BAI65127.1};
GN OrderedLocusNames=RMDY18_12950 {ECO:0000313|EMBL:BAI65127.1};
OS Rothia mucilaginosa (strain DY-18) (Stomatococcus mucilaginosus).
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Micrococcaceae;
OC Rothia.
OX NCBI_TaxID=680646 {ECO:0000313|EMBL:BAI65127.1, ECO:0000313|Proteomes:UP000001883};
RN [1] {ECO:0000313|Proteomes:UP000001883}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DY-18 {ECO:0000313|Proteomes:UP000001883};
RA Yamane K., Nambu T., Mashimo C., Sugimori C., Yamanaka T., Leung K.,
RA Fukushima H.;
RT "Complete genome sequence of Rothia mucilaginosa DJ.";
RL Submitted (JUL-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:BAI65127.1, ECO:0000313|Proteomes:UP000001883}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DY-18 {ECO:0000313|EMBL:BAI65127.1,
RC ECO:0000313|Proteomes:UP000001883};
RA Yamane K., Yoshida M., Fujihira T., Baba T., Tsuji N., Hayashi H.,
RA Sugimori C., Yamanaka T., Mashimo C., Nambu T., Kawai H., Fukushima H.;
RT "Isolation and identification of Rothia mucilaginosa from persistent apical
RT periodontitis lesions.";
RL J Osaka Dent Univ 44:93-98(2010).
RN [3] {ECO:0000313|EMBL:BAI65127.1, ECO:0000313|Proteomes:UP000001883}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DY-18 {ECO:0000313|EMBL:BAI65127.1,
RC ECO:0000313|Proteomes:UP000001883};
RA Yamane K., Nambu T., Yamanaka T., Mashimo C., Sugimori C., Leung K.-P.,
RA Fukushima H.;
RT "Complete Genome Sequence of Rothia mucilaginosa DY-18: A Clinical Isolate
RT with Dense Meshwork-Like Structures from a Persistent Apical Periodontitis
RT Lesion.";
RL Sequencing 2010:457236-457236(2010).
CC -!- SIMILARITY: Belongs to the polysaccharide synthase family.
CC {ECO:0000256|ARBA:ARBA00007430}.
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DR EMBL; AP011540; BAI65127.1; -; Genomic_DNA.
DR RefSeq; WP_012903765.1; NC_013715.1.
DR AlphaFoldDB; D2NU01; -.
DR STRING; 680646.RMDY18_12950; -.
DR KEGG; rmu:RMDY18_12950; -.
DR eggNOG; COG1086; Bacteria.
DR HOGENOM; CLU_013560_5_1_11; -.
DR Proteomes; UP000001883; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd05237; UDP_invert_4-6DH_SDR_e; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR003869; Polysac_CapD-like.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR43318:SF1; POLYSACCHARIDE BIOSYNTHESIS PROTEIN EPSC-RELATED; 1.
DR PANTHER; PTHR43318; UDP-N-ACETYLGLUCOSAMINE 4,6-DEHYDRATASE; 1.
DR Pfam; PF13727; CoA_binding_3; 1.
DR Pfam; PF02719; Polysacc_synt_2; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001883};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 41..64
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 84..106
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 118..138
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 150..169
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 327..603
FT /note="Polysaccharide biosynthesis protein CapD-like"
FT /evidence="ECO:0000259|Pfam:PF02719"
FT REGION 633..652
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 652 AA; 72247 MW; FDD45141BDB38B47 CRC64;
MAQLKPHAHV VMQKAAQRGT MVTEGDSGTM LVNRLYERKP WWLIAQALID SSAWVLAVLF
AYMLRYSVLL SNGSVFDIIH PASLTMTATL AVVLHLAVGL AGVKIYNGVY SYGSFDESWR
AGAAALSAGA ALTAFSFVDE LLGLPHIPHS VPAIAAAFSL IMMAGARMAK RVYTERGAVR
ELTGEPVIVY GAGFIGGMVM DSMLHDEDAK LRPVAVFDDD QLKAGTKFHG ISVITTYREL
EQVIRESGTR KILVTISDMS EDYFESFCNR MRKLKVEVQR ISSANARLMG ERLITASDND
LMRVIRGEIN YDIDRDILRS YLHGKRVLVT GAGGSIGSEL CRQISEFEPE TLMMLDHDET
LLMETKVSIT HESSLDDDRI ILADIREGDN LLEIFRDRRP EVVFHAAALK HVSALEAYPQ
EAWKTNSLGT LNVLRAAEAV GVKTFVNVST DKAADPKTAL GQSKRVAERL TAYFGEKTGN
TYVSVRFGNV FGSRGSIKPL FTKQILSGGP ITLTDKRATR YFMLITDACL LVMLAGAIGR
PGEVMVLDMG QPVKILDVAK AMRQAYERYD VEIKEIGLRK GEKLDETLFG GTEKLVPSEE
NRYISRSSAP ALDPDELDYE RWIQNYREHS GYERHGLERA PDPRTLADAQ TF
//
