ID D2PXL3_KRIFD Unreviewed; 1421 AA.
AC D2PXL3;
DT 02-MAR-2010, integrated into UniProtKB/TrEMBL.
DT 02-MAR-2010, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Glycoside hydrolase family 38 {ECO:0000313|EMBL:ADB31655.1};
GN OrderedLocusNames=Kfla_2587 {ECO:0000313|EMBL:ADB31655.1};
OS Kribbella flavida (strain DSM 17836 / JCM 10339 / NBRC 14399).
OC Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
OC Kribbellaceae; Kribbella.
OX NCBI_TaxID=479435 {ECO:0000313|EMBL:ADB31655.1, ECO:0000313|Proteomes:UP000007967};
RN [1] {ECO:0000313|Proteomes:UP000007967}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 17836 / JCM 10339 / NBRC 14399
RC {ECO:0000313|Proteomes:UP000007967};
RG US DOE Joint Genome Institute (JGI-PGF);
RA Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA Bruce D., Goodwin L., Pitluck S., Kyrpides N., Mavromatis K., Ivanova N.,
RA Saunders E., Brettin T., Detter J.C., Han C., Larimer F., Land M.,
RA Hauser L., Markowitz V., Cheng J.-F., Hugenholtz P., Woyke T., Wu D.,
RA Pukall R., Klenk H.-P., Eisen J.A.;
RT "The complete genome of Kribbella flavida DSM 17836.";
RL Submitted (SEP-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ADB31655.1, ECO:0000313|Proteomes:UP000007967}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 17836 / JCM 10339 / NBRC 14399
RC {ECO:0000313|Proteomes:UP000007967};
RX PubMed=21304701;
RA Pukall R., Lapidus A., Glavina Del Rio T., Copeland A., Tice H.,
RA Cheng J.-F., Lucas S., Chen F., Nolan M., LaButti K., Pati A., Ivanova N.,
RA Mavrommatis K., Mikhailova N., Pitluck S., Bruce D., Goodwin L., Land M.,
RA Hauser L., Chang Y.-J., Jeffries C.D., Chen A., Palaniappan K., Chain P.,
RA Rohde M., Goeker M., Bristow J., Eisen J.A., Markowitz V., Hugenholtz P.,
RA Kyrpides N.C., Klenk H.-P., Brettin T.;
RT "Complete genome sequence of Kribbella flavida type strain (IFO 14399).";
RL Stand. Genomic Sci. 2:186-193(2010).
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 38 family.
CC {ECO:0000256|ARBA:ARBA00009792}.
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DR EMBL; CP001736; ADB31655.1; -; Genomic_DNA.
DR RefSeq; WP_012920211.1; NC_013729.1.
DR STRING; 479435.Kfla_2587; -.
DR CAZy; GH38; Glycoside Hydrolase Family 38.
DR KEGG; kfl:Kfla_2587; -.
DR eggNOG; COG0383; Bacteria.
DR HOGENOM; CLU_002752_0_0_11; -.
DR OrthoDB; 1049785at2; -.
DR Proteomes; UP000007967; Chromosome.
DR GO; GO:0004559; F:alpha-mannosidase activity; IEA:InterPro.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006013; P:mannose metabolic process; IEA:InterPro.
DR CDD; cd10786; GH38N_AMII_like; 1.
DR Gene3D; 3.20.110.10; Glycoside hydrolase 38, N terminal domain; 1.
DR Gene3D; 1.20.1270.50; Glycoside hydrolase family 38, central domain; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR018905; A-galactase_NEW3.
DR InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR InterPro; IPR011330; Glyco_hydro/deAcase_b/a-brl.
DR InterPro; IPR011682; Glyco_hydro_38_C.
DR InterPro; IPR015341; Glyco_hydro_38_cen.
DR InterPro; IPR037094; Glyco_hydro_38_cen_sf.
DR InterPro; IPR000602; Glyco_hydro_38_N.
DR InterPro; IPR027291; Glyco_hydro_38_N_sf.
DR InterPro; IPR028995; Glyco_hydro_57/38_cen_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR PANTHER; PTHR46017; ALPHA-MANNOSIDASE 2C1; 1.
DR PANTHER; PTHR46017:SF1; ALPHA-MANNOSIDASE 2C1; 1.
DR Pfam; PF09261; Alpha-mann_mid; 1.
DR Pfam; PF07748; Glyco_hydro_38C; 1.
DR Pfam; PF01074; Glyco_hydro_38N; 1.
DR Pfam; PF10633; NPCBM_assoc; 1.
DR SMART; SM00872; Alpha-mann_mid; 1.
DR SUPFAM; SSF88688; Families 57/38 glycoside transferase middle domain; 1.
DR SUPFAM; SSF74650; Galactose mutarotase-like; 2.
DR SUPFAM; SSF88713; Glycoside hydrolase/deacetylase; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW Hydrolase {ECO:0000313|EMBL:ADB31655.1};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000007967}.
FT DOMAIN 424..495
FT /note="Glycoside hydrolase family 38 central"
FT /evidence="ECO:0000259|SMART:SM00872"
FT REGION 1299..1319
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1421 AA; 151228 MW; EC501C9FFBF47AC8 CRC64;
MTVQITRVTS PELFVGSDDD PRQILRIELT RSAADGPLAV QVTGDGVTGT TDLPAGDGPV
RVEVPLELPA DQRTAYGAEL PATVTVLTGD GTELARDTGS IVVAEPGWTM VMVSHFHYDP
VWWNTQAAYT TSWDLQGPDG TTRPVYTHNA FSLVDAHLKL ALRDPAYCFV LAELDYLKPY
FDTFPENRAV LRRLIAEGRV EIIGGTYNEP NTNLTGAETT IRNIVYGVGY QRDILGGDPR
NAWQLDVFGH DPQFPGYLAK AGLTGSAWAR GPFHQWGPLR QAWGDPKSGT AAVMQFHSEF
EWISPSGDGV LTHYMPDHYG PGWDLQHAPS VEAAGDTAYQ LFATLKTVAA TKNTLLPVGG
DYTPPNNWIT ALHHDWAERY AWPKFVCGTT KHFMDRVRAE LAAQGRRPSP QSRDMNPIYT
GKDVSYIDTK QAQRAAEVAA VDAEKLGTYA DLLGLGRFAE AALDKVWRQL AYGAHHDAIT
GSESDQVYID LVTGWREAYD LSDAARTAAL EAFAARIDTS AFGGQAVVVT NTLSFTRTDL
VTVELPEAGP VTVLGPDGEA LPSVVEGNKL SFLAENVPSL GWRTYQLADG TPGGWGPADS
ADTVENEFFR VTVDASRGGA VSGILDKRTG RQVLKGLGNE LRVYQEYPDH PRFGEGPWHL
TPSGPVVGST EAPAKVFVQS GPLGSRVVSR GEVDGISYEA VVTAYAGLDR IEFTTRILDH
AQSDRLVRVK FPADVPGALP LSEVAGAVVG RGFGLIDVDS EQAPWTLDNP ANTWFGLGAT
ARIALVDGAG ESVGTRPLAV AEIVVPDDSD PADVRDLVVA LARVGVTATT SLAGGSRYGH
LKVDSNLPDL RILVGAAASL LEDVVDRQGG PSYFPPRTAL AEVWQPNADV RDVRAIPALV
LPTAAAVAAA VAELGEARIT ATVAGEGVIE DFTDATVALL TYGLPGFAVD ATGALHASLL
RSCTGWPSGI WIDPPRRSTP DGSSFQLQHW THEFRYALTA GDGDWRAQQL PARGQEFSSP
LLAATTTAHD GLLPATHSLL QVTPERDVLV STLKPAGNPV AHGSGRPADP RDGVTLRLVE
ATGLGATATI TSAVPITGAT HADLLEHRGA PIEVADGKLT VDLAGAGVDT FVLDLETAVP
AEPAVLGQAG EIAQPSYSRY WLHNRGPAQM GFLPVSLSVS PTVVRTAGQK FEVSMVVANQ
YADTPAVGIL SLDLPEGWTT DQPERTLRLE PGGYVRHLAY VHPAENCEPG QYFVAARIDT
ATDHLAGGAG VRSVEDVVTV FVGESPQLTA SLGFAMAPTE PPDHGAGAAE GEPGRPTGLT
VTPSTLDLRL APGTSATLDL VFANDTSSQI RAELQLASPY GTWSWLPEPV RAVVVPAKSS
VTVPVPVQAP ADATPAHAWV LPKVMWFGRA QYAPTVRLEI Q
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