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Database: UniProt
Entry: D2Q8C3_BIFDB
LinkDB: D2Q8C3_BIFDB
Original site: D2Q8C3_BIFDB 
ID   D2Q8C3_BIFDB            Unreviewed;       400 AA.
AC   D2Q8C3;
DT   02-MAR-2010, integrated into UniProtKB/TrEMBL.
DT   02-MAR-2010, sequence version 1.
DT   08-MAY-2019, entry version 52.
DE   RecName: Full=Phospho-2-dehydro-3-deoxyheptonate aldolase {ECO:0000256|PIRNR:PIRNR001361};
DE            EC=2.5.1.54 {ECO:0000256|PIRNR:PIRNR001361};
GN   Name=aroG1 {ECO:0000313|EMBL:ADB09059.1};
GN   OrderedLocusNames=BDP_0382 {ECO:0000313|EMBL:ADB09059.1};
OS   Bifidobacterium dentium (strain ATCC 27534 / DSM 20436 / JCM 1195 /
OS   Bd1).
OC   Bacteria; Actinobacteria; Bifidobacteriales; Bifidobacteriaceae;
OC   Bifidobacterium.
OX   NCBI_TaxID=401473 {ECO:0000313|EMBL:ADB09059.1, ECO:0000313|Proteomes:UP000008693};
RN   [1] {ECO:0000313|EMBL:ADB09059.1, ECO:0000313|Proteomes:UP000008693}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 27534 / DSM 20436 / JCM 1195 / Bd1
RC   {ECO:0000313|Proteomes:UP000008693};
RX   PubMed=20041198; DOI=10.1371/journal.pgen.1000785;
RA   Ventura M., Turroni F., Zomer A., Foroni E., Giubellini V.,
RA   Bottacini F., Canchaya C., Claesson M.J., He F., Mantzourani M.,
RA   Mulas L., Ferrarini A., Gao B., Delledonne M., Henrissat B.,
RA   Coutinho P., Oggioni M., Gupta R.S., Zhang Z., Beighton D.,
RA   Fitzgerald G.F., O'Toole P.W., van Sinderen D.;
RT   "The Bifidobacterium dentium Bd1 genome sequence reflects its genetic
RT   adaptation to the human oral cavity.";
RL   PLoS Genet. 5:E1000785-E1000785(2009).
CC   -!- FUNCTION: Stereospecific condensation of phosphoenolpyruvate (PEP)
CC       and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-
CC       arabino-heptulosonate-7-phosphate (DAHP).
CC       {ECO:0000256|PIRNR:PIRNR001361}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-erythrose 4-phosphate + H2O + phosphoenolpyruvate = 7-
CC         phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate;
CC         Xref=Rhea:RHEA:14717, ChEBI:CHEBI:15377, ChEBI:CHEBI:16897,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:58394, ChEBI:CHEBI:58702;
CC         EC=2.5.1.54; Evidence={ECO:0000256|PIRNR:PIRNR001361};
CC   -!- PATHWAY: Metabolic intermediate biosynthesis; chorismate
CC       biosynthesis; chorismate from D-erythrose 4-phosphate and
CC       phosphoenolpyruvate: step 1/7. {ECO:0000256|PIRNR:PIRNR001361}.
CC   -!- SIMILARITY: Belongs to the class-I DAHP synthase family.
CC       {ECO:0000256|PIRNR:PIRNR001361}.
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DR   EMBL; CP001750; ADB09059.1; -; Genomic_DNA.
DR   STRING; 401473.BDP_0382; -.
DR   EnsemblBacteria; ADB09059; ADB09059; BDP_0382.
DR   KEGG; bde:BDP_0382; -.
DR   eggNOG; ENOG4105E99; Bacteria.
DR   eggNOG; COG0722; LUCA.
DR   HOGENOM; HOG000220501; -.
DR   KO; K01626; -.
DR   OMA; YDINTGL; -.
DR   UniPathway; UPA00053; UER00084.
DR   Proteomes; UP000008693; Chromosome.
DR   GO; GO:0003849; F:3-deoxy-7-phosphoheptulonate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009073; P:aromatic amino acid family biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009423; P:chorismate biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR006218; DAHP1/KDSA.
DR   InterPro; IPR006219; DHAP_synth_1.
DR   PANTHER; PTHR21225; PTHR21225; 1.
DR   Pfam; PF00793; DAHP_synth_1; 1.
DR   PIRSF; PIRSF001361; DAHP_synthase; 1.
DR   TIGRFAMs; TIGR00034; aroFGH; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis {ECO:0000256|PIRNR:PIRNR001361};
KW   Aromatic amino acid biosynthesis {ECO:0000256|PIRNR:PIRNR001361};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008693};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008693};
KW   Transferase {ECO:0000256|PIRNR:PIRNR001361,
KW   ECO:0000256|SAAS:SAAS00080156, ECO:0000313|EMBL:ADB09059.1}.
FT   DOMAIN       88    387       DAHP_synth_1. {ECO:0000259|Pfam:PF00793}.
SQ   SEQUENCE   400 AA;  43543 MW;  AFB3D75610BE8C8A CRC64;
     MTKERHMQQQ LNTPEELRAI RQAMDEGKNP LVATDVPRWE DQVGISRIVN RRVLEFEVLP
     TPAQVLGELP LSEKAQEIVA YSRDEIRACL YGQDDRLLVI VGPCSVHDPA AALDYARRLA
     GLKDELGGEL LIVMRVYFEK PRTTVGWKGL INDPDIDGSC NIKKGLLLAR HTLLGVLDEG
     LAAATEFLEP TSPQYISDAV SWGAIGARNT ESQVHRQLAS GLSMPIGFKN ATDGSIKAPT
     DSCFASAQTH TFFGIDHLGR AAVVKTLGNP DCHVVLRGSS SGPNYDAASI AKAMETIRGE
     MPADSAAAHG LIVDCSHGNS GKDEHRQAEV VCNIAGRIAQ GEEGITGIMM ESFIEGGNQK
     AAPLDQLVYG RSITDKCLSW DTTERLLREL AHAVSERRWK
//
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