ID D2QUC4_SPILD Unreviewed; 857 AA.
AC D2QUC4;
DT 02-MAR-2010, integrated into UniProtKB/TrEMBL.
DT 02-MAR-2010, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE RecName: Full=Glucosylceramidase {ECO:0008006|Google:ProtNLM};
GN OrderedLocusNames=Slin_6449 {ECO:0000313|EMBL:ADB42406.1};
OS Spirosoma linguale (strain ATCC 33905 / DSM 74 / LMG 10896 / Claus 1).
OC Bacteria; Bacteroidota; Cytophagia; Cytophagales; Cytophagaceae; Spirosoma.
OX NCBI_TaxID=504472 {ECO:0000313|EMBL:ADB42406.1, ECO:0000313|Proteomes:UP000002028};
RN [1] {ECO:0000313|Proteomes:UP000002028}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 33905 / DSM 74 / LMG 10896
RC {ECO:0000313|Proteomes:UP000002028};
RG US DOE Joint Genome Institute (JGI-PGF);
RA Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA Bruce D., Goodwin L., Pitluck S., Kyrpides N., Mavromatis K.,
RA Mikhailova N., Ovchinnikova G., Saunders E., Brettin T., Detter J.C.,
RA Han C., Larimer F., Land M., Hauser L., Markowitz V., Cheng J.-F.,
RA Hugenholtz P., Woyke T., Wu D., Tindal B., Schutze A., Schneider S.,
RA Goker M., Klenk H.-P., Eisen J.A.;
RT "The complete chromosome of Spirosoma linguale DSM 74.";
RL Submitted (SEP-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ADB42406.1, ECO:0000313|Proteomes:UP000002028}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 33905 / DSM 74 / LMG 10896
RC {ECO:0000313|Proteomes:UP000002028};
RX PubMed=21304700;
RA Lail K., Sikorski J., Saunders E., Lapidus A., Glavina Del Rio T.,
RA Copeland A., Tice H., Cheng J.-F., Lucas S., Nolan M., Bruce D.,
RA Goodwin L., Pitluck S., Ivanova N., Mavromatis K., Ovchinnikova G.,
RA Pati A., Chen A., Palaniappan K., Land M., Hauser L., Chang Y.-J.,
RA Jeffries C.D., Chain P., Brettin T., Detter J.C., Schuetze A., Rohde M.,
RA Tindall B.J., Goeker M., Bristow J., Eisen J.A., Markowitz V.,
RA Hugenholtz P., Kyrpides N.C., Klenk H.-P., Chen F.;
RT "Complete genome sequence of Spirosoma linguale type strain (1).";
RL Stand. Genomic Sci. 2:176-185(2010).
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DR EMBL; CP001769; ADB42406.1; -; Genomic_DNA.
DR AlphaFoldDB; D2QUC4; -.
DR STRING; 504472.Slin_6449; -.
DR CAZy; GH116; Glycoside Hydrolase Family 116.
DR KEGG; sli:Slin_6449; -.
DR eggNOG; COG4354; Bacteria.
DR HOGENOM; CLU_010759_0_0_10; -.
DR Proteomes; UP000002028; Chromosome.
DR GO; GO:0004553; F:hydrolase activity, hydrolyzing O-glycosyl compounds; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR Gene3D; 1.50.10.10; -; 1.
DR InterPro; IPR008928; 6-hairpin_glycosidase_sf.
DR InterPro; IPR012341; 6hp_glycosidase-like_sf.
DR InterPro; IPR006775; GH116_catalytic.
DR InterPro; IPR024462; GH116_N.
DR PANTHER; PTHR12654; BILE ACID BETA-GLUCOSIDASE-RELATED; 1.
DR PANTHER; PTHR12654:SF0; NON-LYSOSOMAL GLUCOSYLCERAMIDASE; 1.
DR Pfam; PF04685; DUF608; 1.
DR Pfam; PF12215; Glyco_hydr_116N; 1.
DR SUPFAM; SSF48208; Six-hairpin glycosidases; 1.
PE 4: Predicted;
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..857
FT /note="Glucosylceramidase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003034286"
FT DOMAIN 43..355
FT /note="Glycosyl-hydrolase family 116 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF12215"
FT DOMAIN 478..767
FT /note="Glycosyl-hydrolase family 116 catalytic region"
FT /evidence="ECO:0000259|Pfam:PF04685"
SQ SEQUENCE 857 AA; 95388 MW; 4E2106D640720EEF CRC64;
MKKVIVLLLV FAAFTVKAQS SLWHPQAWPV LKRYDQQHLT RIALPLGGIG TGTVSLGGRG
QLQDWEIMNR PAKGYSTVLT GNTAPFFAIH VLETKKTKAL LGPLESHEYQ HMEGRPVDHH
GLPRFANASF ETAYPFGQVN LSDATMPVSV RIKGFNPLVP TDADASGLPI AVLTYEVTNT
GNQPITVSVC GSMHNFIGRD GSKNHKSWKG ELEPQGAKQN RNQFRQENGL TGIYMYSDGV
DKADAAWGTV ALTTAESQGV SYRTSSVTNA WENALLDFWD DFSDDGKLTE KTTPADEDPM
ASLAVQKTIG PNQTQAFTFF LTWHFPNRFG WSKERVGNYY TTQYNDAWAV ADKTVPLLPK
LEQKTLQFVN ALVQSSYPDE VKEAALFNTS TLRSQTVFRT EDGRMFGWEG IMDDVGSCQG
SCTHVWNYEQ ATPFLFGNLA KTMRDVEFNY AMDDTGLMSF RVGLPLKKGF GGGVAAADGQ
MGTIMKFYRD WQLSGDTDFL RRYWPQVKQA LAFAWVPGGW DANRDGVMEG AQHNTMDVEY
FGPNPQMQLW YLGALKAASA MATAMNDRSF AQTCDQIFQK GSTWTDANLF NGDYYEQQVI
SPAGHLIAKG TFSGFNKVEQ NDPAYQLAKG CLVDQLVGQF MAHVCGLGYL VNPDHIKTTL
KSILKYNYRA SMTDHFNNMR SYALGDEASL LMASWPKGRP KVPFPYFSEV MTGFEYTAAI
GMLYENQTEP GLLCIRNIRN RFDGSKRNPF DEAECGHHYA RAMVSWATTL ALSGFQYSGV
SQVMQFNGQE GTYFWSNGYA WGTCTKTKQA NKLQVTLTVL QGQLPLKSLE IGDKRLVARS
LKEGESFAGT LNYLSNK
//
