ID D2R881_PIRSD Unreviewed; 803 AA.
AC D2R881;
DT 02-MAR-2010, integrated into UniProtKB/TrEMBL.
DT 02-MAR-2010, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Peptidase S9 prolyl oligopeptidase active site domain protein {ECO:0000313|EMBL:ADB15698.1};
DE Flags: Precursor;
GN OrderedLocusNames=Psta_1014 {ECO:0000313|EMBL:ADB15698.1};
OS Pirellula staleyi (strain ATCC 27377 / DSM 6068 / ICPB 4128) (Pirella
OS staleyi).
OC Bacteria; Planctomycetota; Planctomycetia; Pirellulales; Pirellulaceae;
OC Pirellula.
OX NCBI_TaxID=530564 {ECO:0000313|EMBL:ADB15698.1, ECO:0000313|Proteomes:UP000001887};
RN [1] {ECO:0000313|EMBL:ADB15698.1, ECO:0000313|Proteomes:UP000001887}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 27377 / DSM 6068 / ICPB 4128
RC {ECO:0000313|Proteomes:UP000001887};
RX PubMed=21304671; DOI=10.4056/sigs.51657;
RA Clum A., Tindall B.J., Sikorski J., Ivanova N., Mavrommatis K., Lucas S.,
RA Glavina del Rio T., Nolan M., Chen F., Tice H., Pitluck S., Cheng J.F.,
RA Chertkov O., Brettin T., Han C., Detter J.C., Kuske C., Bruce D.,
RA Goodwin L., Ovchinikova G., Pati A., Mikhailova N., Chen A.,
RA Palaniappan K., Land M., Hauser L., Chang Y.J., Jeffries C.D., Chain P.,
RA Rohde M., Goker M., Bristow J., Eisen J.A., Markowitz V., Hugenholtz P.,
RA Kyrpides N.C., Klenk H.P., Lapidus A.;
RT "Complete genome sequence of Pirellula staleyi type strain (ATCC 27377).";
RL Stand. Genomic Sci. 1:308-316(2009).
CC -!- SIMILARITY: Belongs to the VHL family. {ECO:0000256|ARBA:ARBA00010057}.
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DR EMBL; CP001848; ADB15698.1; -; Genomic_DNA.
DR AlphaFoldDB; D2R881; -.
DR STRING; 530564.Psta_1014; -.
DR ESTHER; pirsd-d2r881; DPP4N_Peptidase_S9.
DR KEGG; psl:Psta_1014; -.
DR eggNOG; COG0823; Bacteria.
DR eggNOG; COG1506; Bacteria.
DR HOGENOM; CLU_006105_3_1_0; -.
DR Proteomes; UP000001887; Chromosome.
DR GO; GO:0008236; F:serine-type peptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR CDD; cd05468; pVHL; 1.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 2.140.10.30; Dipeptidylpeptidase IV, N-terminal domain; 1.
DR Gene3D; 2.60.40.780; von Hippel-Lindau disease tumour suppressor, beta domain; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR001375; Peptidase_S9.
DR InterPro; IPR002469; Peptidase_S9B_N.
DR InterPro; IPR024053; VHL_beta_dom.
DR InterPro; IPR037140; VHL_beta_dom_sf.
DR InterPro; IPR036208; VHL_sf.
DR InterPro; IPR022772; VHL_tumour_suppress_b/a_dom.
DR PANTHER; PTHR11731:SF118; BLR1971 PROTEIN; 1.
DR PANTHER; PTHR11731; PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED; 1.
DR Pfam; PF00930; DPPIV_N; 1.
DR Pfam; PF00326; Peptidase_S9; 1.
DR Pfam; PF01847; VHL; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF82171; DPP6 N-terminal domain-like; 1.
DR SUPFAM; SSF49468; VHL; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001887}.
FT DOMAIN 131..191
FT /note="von Hippel-Lindau disease tumour suppressor beta"
FT /evidence="ECO:0000259|Pfam:PF01847"
FT DOMAIN 268..523
FT /note="Dipeptidylpeptidase IV N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00930"
FT DOMAIN 609..787
FT /note="Peptidase S9 prolyl oligopeptidase catalytic"
FT /evidence="ECO:0000259|Pfam:PF00326"
SQ SEQUENCE 803 AA; 90740 MW; BF74A8CADF7C1128 CRC64;
MAWRRGEPPP EPPAFLLPTK ASVMKFAPRL ALALLVMFLI ASASADERID RAQAFSRRIS
GNVFRHRLEP HWLEEGKHLW YRVETGRNRE AFVLVDTTTG EKQTSAKFAD LNLPPPEPIR
TRQATLDRRR SQAGGVASGL RFSNTLDRKV QLWWIDPQGE LVEYETIDAG AKHQQPSYHR
HQWLLRDEAG TDLARIEVGP TIREVLIDGE AENEVRERRA PRGGGGQSPD RKWVAYVEEG
NLLLRNRDSG VIQPLKTDLD PQYPVRGGIT WAPDSQAFVV SYAEKIEPRQ ITIVESTPDD
QLQPKLRQVR YVKPGDPLPR PVPVLFRIEN GKATPQPIDT KLFDHPFTES TQLDIEWADD
SSEFYFDYNA RGHQTFRIIA VDRATALPRA IVEETSPTFI DYTSKTWRHW LPATSELLWM
SERDGWAHLY LVDLKTGAIK NQLTQGAWVV RKIEHVDSEQ RQVWFMASGR RAGEDPYHLH
LCRVNFDGTG LVQLTEGDGT HSAEFSPDRQ LFIDRWSRVD LPPVHQLRRS SDGSLVAELE
SAEITALLET GVQLPERFVA KGRDGVTDIH GFLVKPSNFD PNKKYPIVED IYAGPHSAFV
PKEFGPHARY HTLAELGFIV VKIDGMGTNH RGKAFHDVCY KNLKDAGFPD RIAWIKAAAA
ERPYMDLSRV GIIGGSAGGQ NAMRALLDHH DFYHVAVADC GCHDNRMDKI WWNEQWMGYP
VDESYAQNSN MVDASKLEGH LLLIVGELDT NVDPASTAQV VAALQRARKT FDYMPIMGAG
HGAAETPFGS RLRSEFLLRH LQP
//
