ID D2RFP6_ARCPA Unreviewed; 273 AA.
AC D2RFP6;
DT 02-MAR-2010, integrated into UniProtKB/TrEMBL.
DT 02-MAR-2010, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE RecName: Full=Translation initiation factor 2 subunit alpha {ECO:0000256|ARBA:ARBA00013678, ECO:0000256|HAMAP-Rule:MF_00231};
DE AltName: Full=aIF2-alpha {ECO:0000256|ARBA:ARBA00030860, ECO:0000256|HAMAP-Rule:MF_00231};
DE AltName: Full=eIF-2-alpha {ECO:0000256|ARBA:ARBA00033333, ECO:0000256|HAMAP-Rule:MF_00231};
GN Name=eif2a {ECO:0000256|HAMAP-Rule:MF_00231};
GN OrderedLocusNames=Arcpr_0044 {ECO:0000313|EMBL:ADB57121.1};
OS Archaeoglobus profundus (strain DSM 5631 / JCM 9629 / NBRC 100127 / Av18).
OC Archaea; Euryarchaeota; Archaeoglobi; Archaeoglobales; Archaeoglobaceae;
OC Archaeoglobus.
OX NCBI_TaxID=572546 {ECO:0000313|EMBL:ADB57121.1, ECO:0000313|Proteomes:UP000001901};
RN [1] {ECO:0000313|EMBL:ADB57121.1, ECO:0000313|Proteomes:UP000001901}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 5631 / JCM 9629 / NBRC 100127 / Av18
RC {ECO:0000313|Proteomes:UP000001901};
RX PubMed=21304717;
RA von Jan M., Lapidus A., Del Rio T.G., Copeland A., Tice H., Cheng J.F.,
RA Lucas S., Chen F., Nolan M., Goodwin L., Han C., Pitluck S., Liolios K.,
RA Ivanova N., Mavromatis K., Ovchinnikova G., Chertkov O., Pati A., Chen A.,
RA Palaniappan K., Land M., Hauser L., Chang Y.J., Jeffries C.D., Saunders E.,
RA Brettin T., Detter J.C., Chain P., Eichinger K., Huber H., Spring S.,
RA Rohde M., Goker M., Wirth R., Woyke T., Bristow J., Eisen J.A.,
RA Markowitz V., Hugenholtz P., Kyrpides N.C., Klenk H.P.;
RT "Complete genome sequence of Archaeoglobus profundus type strain (AV18).";
RL Stand. Genomic Sci. 2:327-346(2010).
CC -!- FUNCTION: eIF-2 functions in the early steps of protein synthesis by
CC forming a ternary complex with GTP and initiator tRNA.
CC {ECO:0000256|ARBA:ARBA00003323, ECO:0000256|HAMAP-Rule:MF_00231}.
CC -!- SUBUNIT: Heterotrimer composed of an alpha, a beta and a gamma chain.
CC {ECO:0000256|ARBA:ARBA00011243, ECO:0000256|HAMAP-Rule:MF_00231}.
CC -!- SIMILARITY: Belongs to the eIF-2-alpha family.
CC {ECO:0000256|ARBA:ARBA00007223, ECO:0000256|HAMAP-Rule:MF_00231}.
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DR EMBL; CP001857; ADB57121.1; -; Genomic_DNA.
DR RefSeq; WP_012939457.1; NC_013741.1.
DR AlphaFoldDB; D2RFP6; -.
DR STRING; 572546.Arcpr_0044; -.
DR PaxDb; 572546-Arcpr_0044; -.
DR GeneID; 8738689; -.
DR KEGG; apo:Arcpr_0044; -.
DR eggNOG; arCOG04107; Archaea.
DR HOGENOM; CLU_033458_0_2_2; -.
DR OrthoDB; 84794at2157; -.
DR Proteomes; UP000001901; Chromosome.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR CDD; cd04452; S1_IF2_alpha; 1.
DR Gene3D; 3.30.70.1130; EIF_2_alpha; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR HAMAP; MF_00231; eIF_2_alpha; 1.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR003029; S1_domain.
DR InterPro; IPR044126; S1_IF2_alpha.
DR InterPro; IPR022964; TIF2_asu_arc.
DR InterPro; IPR024055; TIF2_asu_C.
DR InterPro; IPR024054; TIF2_asu_middle_sf.
DR InterPro; IPR011488; TIF_2_asu.
DR PANTHER; PTHR10602; EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1; 1.
DR PANTHER; PTHR10602:SF0; EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1; 1.
DR Pfam; PF07541; EIF_2_alpha; 1.
DR Pfam; PF00575; S1; 1.
DR SMART; SM00316; S1; 1.
DR SUPFAM; SSF110993; eIF-2-alpha, C-terminal domain; 1.
DR SUPFAM; SSF116742; eIF2alpha middle domain-like; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR PROSITE; PS50126; S1; 1.
PE 3: Inferred from homology;
KW Initiation factor {ECO:0000256|ARBA:ARBA00022540, ECO:0000256|HAMAP-
KW Rule:MF_00231};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917, ECO:0000256|HAMAP-
KW Rule:MF_00231}; Reference proteome {ECO:0000313|Proteomes:UP000001901};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|HAMAP-
KW Rule:MF_00231}.
FT DOMAIN 20..91
FT /note="S1 motif"
FT /evidence="ECO:0000259|PROSITE:PS50126"
SQ SEQUENCE 273 AA; 31352 MW; C2B36BC4EBA7C8FE CRC64;
MSEEKEERLI IKRDGYPSPG EIVIGTVTRV MDFGAFVSLD EYENKEGMVH ISEVAPGWIK
DIRDHVKKGQ KVVCKVLGVN PKRGHIDLSI KDVTERQKRE KWQEWKNELK AFKWLEIIGE
KLGLSREQLI EIGKKLIKEY DSVYEAFVEC AYEGYEVLAK IVGEEFAKEM AEIARENIKP
PRVKVRGYFE LKSYAGDGVE RIKKALMKAY DVIKKFPNIK AEIEYVGAPR YRIVLEADDY
KVAEKALKSV VDTVLKTIKR LGGEGNFVRE HIG
//
