ID D2RJS9_ACIFV Unreviewed; 307 AA.
AC D2RJS9;
DT 02-MAR-2010, integrated into UniProtKB/TrEMBL.
DT 02-MAR-2010, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase {ECO:0000313|EMBL:ADB47331.1};
GN OrderedLocusNames=Acfer_0950 {ECO:0000313|EMBL:ADB47331.1};
OS Acidaminococcus fermentans (strain ATCC 25085 / DSM 20731 / CCUG 9996 / CIP
OS 106432 / VR4).
OC Bacteria; Bacillota; Negativicutes; Acidaminococcales; Acidaminococcaceae;
OC Acidaminococcus.
OX NCBI_TaxID=591001 {ECO:0000313|EMBL:ADB47331.1, ECO:0000313|Proteomes:UP000001902};
RN [1] {ECO:0000313|EMBL:ADB47331.1, ECO:0000313|Proteomes:UP000001902}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25085 / DSM 20731 / CCUG 9996 / CIP 106432 / VR4
RC {ECO:0000313|Proteomes:UP000001902};
RX PubMed=21304687; DOI=10.4056/sigs.1002553;
RA Chang Y.J., Pukall R., Saunders E., Lapidus A., Copeland A., Nolan M.,
RA Glavina Del Rio T., Lucas S., Chen F., Tice H., Cheng J.F., Han C.,
RA Detter J.C., Bruce D., Goodwin L., Pitluck S., Mikhailova N., Liolios K.,
RA Pati A., Ivanova N., Mavromatis K., Chen A., Palaniappan K., Land M.,
RA Hauser L., Jeffries C.D., Brettin T., Rohde M., Goker M., Bristow J.,
RA Eisen J.A., Markowitz V., Hugenholtz P., Kyrpides N.C., Klenk H.P.;
RT "Complete genome sequence of Acidaminococcus fermentans type strain
RT (VR4).";
RL Stand. Genomic Sci. 3:1-14(2010).
CC -!- SIMILARITY: Belongs to the carbon-nitrogen hydrolase superfamily.
CC Nitrilase family. {ECO:0000256|ARBA:ARBA00008129}.
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DR EMBL; CP001859; ADB47331.1; -; Genomic_DNA.
DR RefSeq; WP_012938320.1; NZ_CP085936.1.
DR AlphaFoldDB; D2RJS9; -.
DR SMR; D2RJS9; -.
DR STRING; 591001.Acfer_0950; -.
DR GeneID; 78334695; -.
DR KEGG; afn:Acfer_0950; -.
DR eggNOG; COG0388; Bacteria.
DR HOGENOM; CLU_030130_6_1_9; -.
DR OrthoDB; 9811121at2; -.
DR Proteomes; UP000001902; Chromosome.
DR GO; GO:0016746; F:acyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0000257; F:nitrilase activity; IEA:UniProt.
DR GO; GO:0006807; P:nitrogen compound metabolic process; IEA:InterPro.
DR CDD; cd07564; nitrilases_CHs; 1.
DR Gene3D; 3.60.110.10; Carbon-nitrogen hydrolase; 1.
DR InterPro; IPR003010; C-N_Hydrolase.
DR InterPro; IPR036526; C-N_Hydrolase_sf.
DR InterPro; IPR000132; Nitrilase/CN_hydratase_CS.
DR InterPro; IPR044149; Nitrilases_CHs.
DR PANTHER; PTHR46044:SF1; CN HYDROLASE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR46044; NITRILASE; 1.
DR Pfam; PF00795; CN_hydrolase; 1.
DR SUPFAM; SSF56317; Carbon-nitrogen hydrolase; 1.
DR PROSITE; PS50263; CN_HYDROLASE; 1.
DR PROSITE; PS00920; NITRIL_CHT_1; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000313|EMBL:ADB47331.1};
KW Lipoprotein {ECO:0000313|EMBL:ADB47331.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001902};
KW Transferase {ECO:0000313|EMBL:ADB47331.1}.
FT DOMAIN 8..278
FT /note="CN hydrolase"
FT /evidence="ECO:0000259|PROSITE:PS50263"
FT ACT_SITE 48
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10139"
SQ SEQUENCE 307 AA; 34356 MW; 99F4348EF539B28B CRC64;
MQDLKKDLRL ALVQLEPVLF DKAACLGNTL KKLAEAAENG AEFIVFPELS IPGYPFGMTF
GFKIGSRSEA GRKDWKRYYD ASVVVPGPET DAIAKAAQKY QVYTSIGISE RDAVTGTLYN
TNLIFSPEGR LVSHHRKLKP TGAERLVWGD AHEKYFPMAD TPWGSAGCMI CWESYMPLAR
AALYEHGVTL YISANTNDVP EWQHTIQHIA LEGRCFVINS DLFFTKHSYP SDLEAKEELA
QLPEIVCRGG SCVIDPFGHY LTEPVWDKET IIYADLDMDQ VAASRMEFDP CGHYARPDVL
KFEASKA
//
